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The Division of Intramural Research provides fundamental knowledge about the nature and behavior of living systems through basic, clinical, and population-based research.

A 30-minute, self-administered online training module can protect adolescents from unhealthy responses to stress and related mental health consequences, suggests research funded in part by NICHD.

NICHD’s Dr. Claire Le Pichon helps advance understanding of neuron injury and neurodegenerative diseases by embracing new technologies, collaborating with other researchers, and mentoring the next generation of scientists. Read about her career path.

The Division of Intramural Research provides fundamental knowledge about the nature and behavior of living systems through basic, clinical, and population-based research.

The amygdala—a brain structure enlarged in two-year-old children diagnosed with autism spectrum disorder (ASD)—begins its accelerated growth between 6 and 12 months of age, suggests a study funded by the National Institutes of Health. The amygdala is involved in processing emotions, such as interpreting facial expressions or feeling afraid when exposed to a threat. The findings indicate that therapies to reduce the symptoms of ASD might have the greatest chance of success if they begin in the first year of life, before the amygdala begins its accelerated growth.

The Division of Intramural Research provides fundamental knowledge about the nature and behavior of living systems through basic, clinical, and population-based research.

Infants born during the pandemic—regardless of whether their mothers had COVID-19 during pregnancy—scored slightly lower on certain tests of neurodevelopment at 6 months old, compared to a similar group of infants born before the pandemic, according to a study funded by the National Institutes of Health. The findings suggest that children born during the pandemic may need long-term monitoring to rapidly identify any future lags in development. The researchers theorized that maternal stress resulting from the pandemic could have effects on children’s neurodevelopment.

Read about NICHD’s research findings and activities from 2021.

Specialized regions in infant brains appear to respond to visual information in much the same way adult brains do, according to a study funded by the National Institutes of Health. Located in the visual cortex, these brain regions selectively process faces, bodies, or scenes. Previously, researchers had believed that it took years for these regions to develop before they would function like an adult’s visual cortex. The findings may provide information helpful for understanding disorders in which facial recognition is impaired, such as autism spectrum disorder and bipolar disorder.

Riluzole, a drug approved to treat amyotrophic lateral sclerosis (ALS), a disease affecting nerve cells controlling movement, could slow the gradual loss of a particular brain cell that occurs in Niemann-Pick disease type C1 (NPC1), a rare genetic disorder affecting children and adolescents, suggests a study in mice by scientists at the National Institutes of Health.

The newly published 2021 NIH Research Plan on Rehabilitation reflects advances since the previous plan was released in 2016 and new directions that will help guide rehabilitation research across NIH for the next five years.

Episodes of maternal stress or depression during pregnancy are associated with chemical modifications to placental genes, according to a study by researchers from the National Institutes of Health. The modifications involve DNA methylation—binding of compounds known as methyl groups to DNA—which can alter a gene’s activity. Some of the methylation changes associated with maternal depression occurred near genes involved in brain development, suggesting that maternal depression in pregnancy could have long-term implications for the mental development of the child.

An environment in which family members support one another and express their feelings can reduce the effects of social deprivation on cognitive ability and development among adopted children, suggests a small study by researchers at the National Institutes of Health. In contrast, rule-driven households where family members are in conflict may increase an adopted child’s chances for cognitive, behavioral and emotional difficulties.

NICHD Director Dr. Diana Bianchi is joined by NIH Office of Research on Women’s Health Director Dr. Janine Clayton in assessing the growing maternal health crisis in the United States and describing NIH’s efforts to address it.

Mouse study provides atlas to pinpoint neurons involved in neurodegenerative diseases.

Preliminary data from NICHD-funded researchers provides caregiver-reported information on how children and teens fared during the first months of the COVID-19 pandemic.

Looking back and looking ahead. NICHD Director Dr. Diana W. Bianchi joins other leaders across NIH in reflecting on the work of the Rapid Acceleration of Diagnostics (RADx) program and discussing plans for the future.

For many COVID-19 patients, full recovery remains elusive even long after they should feel “better.” NIH recently announced research opportunities to understand COVID-19 long haulers, who have what researchers now refer to as Post-acute sequelae of SARS-CoV-2 infection (PASC). NICHD joins these opportunities while remaining focused on PASC patients within our audiences of interest—pregnant and lactating people, children, and those with disabilities.

Physicians could improve prescribing practices for children with severe neurological impairments by periodically administering parent questionnaires to assess the children’s symptoms, suggests a study funded by the National Institutes of Health. Such routine assessments could help detect adverse effects of drug interactions or cases in which medications have been under or overprescribed.

The National Center for Medical Rehabilitation was established in 1990 through the landmark Americans with Disabilities Act.