The NICHD conducts and supports a variety of clinical research related to pituitary tumors. Select a link below to learn more about these projects.
Featured NICHD Clinical Trials
Mifepristone in Children with Refractory Cushing’s Disease
There are currently no approved therapies for children with Cushing's disease who are not cured by surgery alone. A drug called mifepristone has been approved to treat adults with Cushing's syndrome and elevated blood glucose caused by Cushing's. Researchers at NIH want to learn if mifepristone improves Cushing’s disease in children as it does in adults. Eligible participants will receive 12 weeks of mifepristone (there is no placebo) followed by a 12-week off-medication observation period.
An Investigation of Pituitary Tumors and Related Hypothalamic Disorders
The purpose of this study is two-fold. As a screening and training study, fellows and students at the NIH Clinical Center will observe and learn from children with pituitary tumors. The aims of the research study include developing new clinical studies for the detection and treatment of pituitary tumors and studying the inheritance pattern of pituitary tumors in childhood.
Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex
This study will use clinical testing for endocrine and nonendocrine diseases and genetic testing to define the genetic basis for PPNAD and/or the Carney Complex, determine any molecular changes, identify and determine prognosis for carriers of the disease, and provide sufficient data for genetic counseling
Assessment of Sensitivity of the Hypothalamic GnRH Pulse Generator to Estradiol and Progesterone Inhibition in Early Pubertal Girls (JCM026)
The purpose of this study is to evaluate how GnRH and LH pulses are controlled during puberty to learn more about how menstrual cycles are normally established in girls during puberty.
NICHD Clinical Trials
ClinicalTrials.gov Search Results
Information on current NIH-sponsored clinical trials is available by following the link below or by calling 800-411-1222.