Pelvic Floor Disorders: Clinical Trials

The NICHD conducts and supports a variety of clinical research related to PFDs. Select a link below to learn more about these projects.

Featured NICHD Clinical Trials

  • ABC: Anticholinergics versus Botox Comparison in Women with Urge Incontinence External Web Site Policy
    The goal of this randomized clinical trial is to compare the change in urge incontinence episodes between women receiving botulinum toxin A in bladder muscle plus daily oral placebo tablets, versus women receiving a similar injection of saline plus daily anticholinergic therapy.
  • BOOST: Behavioral Therapy Of Obstetric Sphincter Tears External Web Site Policy
    This study is designed to determine the incidence of fecal incontinence symptoms in women who sustained an anal sphincter injury when delivering their first child.
  • Botulinum Toxin for Pelvic Pain in Women with Endometriosis
    Botulinum toxin injection is widely used to treat conditions associated with excessive muscle activity and spasm. In this study, researchers want to see if botulinum toxin injections into the pelvic floor muscles can decrease pain and spasms in women with pelvic pain.
  • OPTIMAL: Operations and Pelvic Muscle Training in the Management of Apical Support Loss External Web Site Policy
    This trial assesses health-related quality of life following surgery for vaginal prolapse and stress urinary incontinence. It compares the effects of sacrospinous ligament fixation versus uterosacral ligament suspension with and without perioperative behavioral therapy and pelvic muscle training .
    • E-OPTIMAL: Extended Follow-up of Patients Enrolled in OPTIMAL External Web Site Policy
      The Extended Operations and Pelvic Muscle Training in the Management of Apical Support Loss (E-OPTIMAL) study extends the period of follow-up to 5 years with women who were treated for pelvic organ prolapse and stress urinary incontinence with one of two surgical approaches. The study will compare the success and complication rates of the two surgical treatment groups.
  • Refractory Overactive Bladder: Sacral NEuromodulation v. BoTulinum Toxin Assessment (ROSETTA)
    This study compares the effectiveness of botulinum toxin A versus sacral neuromodulation for the treatment of urge urinary incontinence.

NICHD Clinical Trials Search Results

Information on current NIH-sponsored clinical trials on PFDs is available at the link below or by calling 800-411-1222.

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