The Obstetric and Pediatric Pharmacology and Therapeutics Branch established the MPRINT Hub to aggregate, present, and expand the available knowledge, tools, and expertise in maternal and pediatric therapeutics to the broader research, regulatory science, and drug development communities. It will serve as a national resource for conducting and fostering therapeutics-focused research in obstetrics, lactation, and pediatrics while enhancing inclusion of people with disabilities.
The MPRINT Hub comprises the Indiana University-Ohio State University Data and Model Knowledge and Research Coordination Center (KRCC) and two Centers of Excellence in Therapeutics (CETs): the Vanderbilt Integrated Center of Excellence in Maternal and Pediatric pRecisioN Therapeutics and the University of California San Diego MPRINT Center of Excellence in Therapeutics .
The MPRINT KRCC will coordinate and support the operations of the entire MPRINT Hub, interface with the CETs, and develop a web portal to access an underlying curated knowledge base of maternal and pediatric pharmacology and therapeutics. This knowledge base will aggregate and identify knowledge deficits in the principles of maternal and pediatric therapeutics including pharmacokinetics, pharmacodynamics, genetics, proteomics, and metabolomics that inform drug development and regulatory science.
The MPRINT CETs will work together and with the MPRINT KRCC, the central coordinating center of the MPRINT Hub, to serve as a national resource for knowledge and expertise in maternal and pediatric pharmacology and as a research center to close deficits in knowledge and technical expertise. The MPRINT CETs will conduct cutting edge clinical, translational, basic, and/or data sciences research; provide resources; and generate novel tools and approaches to advance and accelerate research and regulatory science in maternal and pediatric therapeutics.
The MPRINT KRCC will serve as the primary administrative component and public-facing component of the MPRINT Hub as well as a conduit to the resources in its other components such as the MPRINT CETs. Additionally, the MPRINT KRCC will oversee an opportunity pool of funds to address emergent needs in support of national research in maternal and pediatric therapeutics.