Program seeks Council approval for an initiative titled “ORACLE 3C: Chronic Conditions, Coinfections, and Comorbidities in HIV." These conditions arise from complex biological processes that often manifest unique pathophysiology in the context of HIV. These complexities become even more pronounced in pediatric, adolescent, and maternal populations, where developmental and physiological dynamics shape susceptibility, disease trajectories, and clinical outcomes. Addressing these challenges requires innovative approaches alongside rigorous mechanistic and translational research to advance lifelong health.
This Initiative seeks to catalyze progress and address the evolving landscape of HIV morbidity and mortality by supporting research examining the intersection of HIV 3Cs in these priority populations. Central to this effort is the development or application of cutting-edge methodological approaches, emerging technologies, and implementation science strategies capable of elucidating novel biological, clinical, and behavioral mechanisms.
To accelerate discovery and innovation, research proposals must pursue bold, original scientific directions that are clearly differentiated from an investigator's existing research or the broader field. Catalytic advances may stem from the use of exceptionally creative methodologies or the testing of bold hypotheses with the potential to transform current understanding of HIV 3Cs.
Recognizing the importance of cultivating the next generation of HIV researchers, this Initiative encourages the participation of early-stage investigators. Collectively these efforts aim to lay the groundwork for sustained advances that support healthier futures for individuals affected by or living with HIV.
This proposed concept aligns with all 5 NICHD Strategic Plan Research Goals and all MPIDB research priorities.
This Initiative addresses all NIH HIV/AIDS Research Priorities with an emphasis on a) HIV-associated comorbidities, coinfections, and complications and b) basic research: understanding the basic biology of HIV transmission and pathogenesis..
Program Contact
Samantha Calabrese
Maternal and Pediatric Infectious Disease Branch (MPIDB)
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