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Mouse Strains

The following mouse mutants are available for distribution.

Igf2/H19 Regulatory Elements (available as live mice)

  • H19-DICR (or DMJ) deletes sequences between -10 and -1 kb upstream of the H19 transcriptional start site.  This deletion removes the H19DMR and results in loss of imprinting of the Igf2 and H19 genes.  See Kaffer et al. 2000.
  • H19-ICRflox (or MJ) carries loxP insertions at the -7 and -1 kb positions upstream of the H19 transcriptional start site.  Thus the H19DMR is flanked with loxP elements.
  • UGI8 mice are FVB congenics that carry a distal 7 chromosome that is M. castaneus in origin.  See Gould and Pfeifer 1998.
  • H19-DME (or VM3) deletes sequences between +10 and +34 Kb downstream of the H19 transcriptional start site.  This deletion removes sequences essential for expression of H19 and of  Igf2 in skeletal muscle.  See Kaffer et al. 2001.
  • H19-DCTCF deletes 400 bp at +28kb.  This deletion removes muscle specific CTCF binding sites.
  • H19BAC (or EI27) carries an BAC transgene including the H19 gene and 7 kb of upstream and approximately 140 kb of downstream sequences.  See Kaffer et al. 2000.
  • H19DEx1 (or DMIL) deletes 700 bp within H19 exon 1.  The truncated RNA is unstable. Thus this deletion results in depletion of H19 lncRNA without altering levels of H19-dependent miRNA 675.  See Srivastava  et al. 2003.

Kcnq1 (available only as frozen embryos)

  • J800 carries an insertion/deletion mutation at the Kcnq1 gene and results in a complete loss in Kcnq1 gene activity.  See Casimiro et al. 2001.
  • J343 carries a point mutations in Kcnq1 resulting in the following change the Kcnq1 peptide: A340E. See Casimiro et al. 2004.

Casq2 (available as live mice)

  • Casq2Δ (or Δ588) carries a deletion of the Casq2 promoter and exon 1.  No Casq2 mRNA or protein are detectable.  See Knollman et al. 2006.
  • Casq2-Floxed (or Casq2-588) carries loxP insertions around Casq2 promoter and exon 1. This allele is functionally wild type but cre-mediated recombination results in a Casq2 null allele.  See Flores et al. 2018.
  • Casq2-RevFloxed (or Casq2-700) inverts the Casq2 promoter and exon 1 and flanks them with inverted loxP sites.  This allele is functionally null but cre-mediated recombination results in a functionally wild type Casq2 allele. See Flores et al. 2018.
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