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MyNCBI bibliography

2019

Maio N, Ghosh MC, Costain G, Carnevale A, Si Y, Yoon G, Rouault TA. (2019) Reply: IREB2-associated neurodegeneration. Brain 142(8):e41. PMID: 31243430, DOI: 10.1093/brain/awz185
Rouault TA. (2019)The indispensable role of mammalian iron sulfur proteins in function and regulation of multiple diverse metabolic pathways. Biometals 32(3):343-353. PMID: 30923992, DOI: 10.1007/s10534-019-00191-7
Costain G, Ghosh MC, Maio N, Carnevale A, Si YC, Rouault TA, Yoon G. (2019)Absence of iron-responsive element-binding protein 2 causes a novel neurodegenerative syndrome. Brain 142(5):1195-1202. PMID: 30915432, DOI: 10.1093/brain/awz072
Maio N, Kim KS, Holmes-Hampton G, Singh A, Rouault TA.(2019) Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis. Haematologica pii: haematol.2018.214320. PMID: 30765471, DOI: 10.3324/haematol.2018.214320

2018

Rice CM, Davies LC, Subleski JJ, Maio N, Gonzalez-Cotto M, Andrews C, Patel NL, Palmieri EM, Weiss JM, Lee JM, Annunziata CM, Rouault TA, Durum SK, McVicar DW. (2018) Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression. Nat Commun 9(1):5099. PMID: 30504842, DOI: 10.1038/s41467-018-07505-2
Kim KS, Zhang DL, Kovtunovych G, Ghosh MC, Ollivierre H, Eckhaus MA, Rouault TA. (2018) Infused wild-type macrophages reside and self-renew in the liver to rescue the hemolysis and anemia of Hmox1-deficient mice. Blood Adv 2(20):2732-2743. PMID: 30337301, DOI: 10.1182/bloodadvances.2018019737
Zhang DL, Ghosh MC, Ollivierre H, Li Y, Rouault TA. (2018) Ferroportin deficiency in erythroid cells causes serum iron deficiency and promotes hemolysis due to oxidative stress. Blood 132(19):2078-2087. PMID: 30213870, DOI: 10.1182/blood-2018-04-842997
Rouault TA. (2018) Heme, whence come thy carbon building blocks? Blood 132(10):981-982. PMID: 30190349, DOI: 10.1182/blood-2018-07-864215
Tong WH, Maio N, Zhang DL, Palmieri EM, Ollivierre H, Ghosh MC, McVicar DW, Rouault TA. (2018) TLR-activated repression of Fe-S cluster biogenesis drives a metabolic shift and alters histone and tubulin acetylation. Blood Adv 2(10):1146-1156. PMID: 29784770, DOI: 10.1182/bloodadvances.2018015669
Holmes-Hampton GP, Ghosh MC, Rouault TA. (2018) Methods for Studying Iron Regulatory Protein 1: An Important Protein in Human Iron Metabolism. Methods Enzymol 599:139-155. PMID: 29746238, DOI: 10.1016/bs.mie.2017.09.006
Zhang DL, Wu J, Shah BN, Greutélaers KC, Ghosh MC, Ollivierre H, Su XZ, Thuma PE, Bedu-Addo G, Mockenhaupt FP, Gordeuk VR, Rouault TA. (2018) Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk. Science 359(6383):1520-1523. PMID: 29599243, DOI: 10.1126/science.aal2022
Crooks DR, Maio N, Lane AN, Jarnik M, Higashi RM, Haller RG, Yang Y, Fan TW, Linehan WM, Rouault TA. (2018) Acute loss of iron-sulfur clusters results in metabolic reprogramming and generation of lipid droplets in mammalian cells. J Biol Chem 293(21):8297-8311. PMID: 29523684, DOI: 10.1074/jbc.RA118.001885
Ghosh MC, Zhang DL, Ollivierre H, Eckhaus MA, Rouault TA. (2018) Translational repression of HIF2α expression in mice with Chuvash polycythemia reverses polycythemia. J Clin Invest 128(4):1317-1325. PMID: 29480820, DOI: 10.1172/JCI97684
Zhang DL, Rouault TA. (2018) How does hepcidin hinder ferroportin activity? Blood 131(8):840-842. PMID: 29472371, DOI: 10.1182/blood-2018-01-824151
Kim KS, Maio N, Singh A, Rouault TA. (2018) Cytosolic HSC20 integrates de novo iron-sulfur cluster biogenesis with the CIAO1-mediated transfer to recipients. Hum Mol Genet 27(5):837-852. PMID: 29309586, DOI: 10.1093/hmg/ddy004
Truman-Rosentsvit M, Berenbaum D, Spektor L, Cohen LA, Belizowsky-Moshe S, Lifshitz L, Ma J, Li W, Kesselman E, Abutbul-Ionita I, Danino D, Gutierrez L, Li H, Li K, Lou H, Regoni M, Poli M, Glaser F, Rouault TA, Meyron-Holtz EG. (2018) Ferritin is secreted via 2 distinct nonclassical vesicular pathways. Blood 131(3):342-352. PMID: 29074498, DOI: 10.1182/blood-2017-02-768580

2017

Rouault TA, Maio N. (2017) Biogenesis and functions of mammalian iron-sulfur proteins in the regulation of iron homeostasis and pivotal metabolic pathways. J Biol Chem 292(31):12744-12753. PMID: 28615439, DOI: 10.1074/jbc.R117.789537
Maio N, Kim KS, Singh A, Rouault TA. (2017) A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III. Cell Metab 25(4):945-953.e6. PMID: 28380382, DOI: 10.1016/j.cmet.2017.03.010

2016

Maio N, Rouault TA. (2016) Mammalian Fe-S proteins: definition of a consensus motif recognized by the co-chaperone HSC20. Metallomics 8(10):1032-1046. PMID: 27714045, DOI: 10.1039/c6mt00167j
Holmes-Hampton GP, Crooks DR, Haller RG, Guo S, Freier SM, Monia BP, Rouault TA. (2016) Use of antisense oligonucleotides to correct the splicing error in ISCU myopathy patient cell lines. Hum Mol Genet 25(23):5178-5187. PMID: 28007899, DOI: 10.1093/hmg/ddw338
Rouault TA. (2016) Mitochondrial iron overload: causes and consequences. Curr Opin Genet Dev 38:31-37. PMID: 27026139, DOI: 10.1016/j.gde.2016.02.004
Cloonan SM, Glass K, Laucho-Contreras ME, Bhashyam AR, Cervo M, Pabón MA, Konrad C, Polverino F, Siempos II, Perez E, Mizumura K, Ghosh MC, Parameswaran H, Williams NC, Rooney KT, Chen ZH, Goldklang MP, Yuan GC, Moore SC, Demeo DL, Rouault TA, D'Armiento JM, Schon EA, Manfredi G, Quackenbush J, Mahmood A, Silverman EK, Owen CA, Choi AM. (2016) Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice. Nat Med 22(2):163-74. PMID: 26752519, DOI: 10.1038/nm.4021
Maio N, Ghezzi D, Verrigni D, Rizza T, Bertini E, Martinelli D, Zeviani M, Singh A, Carrozzo R, Rouault TA. (2016) Disease-Causing SDHAF1 Mutations Impair Transfer of Fe-S Clusters to SDHB. Cell Metab 23(2):292-302. PMID: 26749241, DOI: 10.1016/j.cmet.2015.12.005
Saxena N, Maio N, Crooks DR, Ricketts CJ, Yang Y, Wei MH, Fan TW, Lane AN, Sourbier C, Singh A, Killian JK, Meltzer PS, Vocke CD, Rouault TA, Linehan WM. (2016) SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery.J Natl Cancer Inst 108(1). PMID: 26719882, DOI: 10.1093/jnci/djv287

2015

Ghosh MC, Zhang DL, Rouault TA. (2015) Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins. Neurobiol Dis 81:66-75. PMID: 25771171, DOI: 10.1016/j.nbd.2015.02.026
Rouault TA. (2015) Iron-sulfur proteins hiding in plain sight. Nat Chem Biol 11(7):442-5. PMID: 26083061, DOI: 10.1038/nchembio.1843
Maio N, Rouault TA. (2015) Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Biochim Biophys Acta 1853(6):1493-1512. PMID: 25245479, DOI: 10.1016/j.bbamcr.2014.09.009

2014

Sourbier C, Ricketts CJ, Matsumoto S, Crooks DR, Liao PJ, Mannes PZ, Yang Y, Wei MH, Srivastava G, Ghosh S, Chen V, Vocke CD, Merino M, Srinivasan R, Krishna MC, Mitchell JB, Pendergast AM, Rouault TA, Neckers L, Linehan WM. (2014) Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer. Cancer Cell 26(6):840-50. PMID: 25490448, DOI: 10.1016/j.ccell.2014.10.005
Holmes-Hampton GP, Tong WH, Rouault TA. (2014) Biochemical and biophysical methods for studying mitochondrial iron metabolism. Methods Enzymol 547:275-307. PMID: 25416363, DOI: 10.1016/B978-0-12-801415-8.00015-1
Rouault TA. (2014) Mammalian iron–sulphur proteins: novel insights into biogenesis and function. Nat Rev Mol Cell Biol 16(1):45-55. PMID: 25425402, DOI: 10.1038/nrm3909
Zhang DL, Ghosh MC, Rouault TA. (2014) The physiological functions of iron regulatory proteins in iron homeostasis—an update. Front Pharmacol 5:124. PMID: 24982634, DOI: 10.3389/fphar.2014.00124
Kovtunovych G, Ghosh MC, Ollivierre W, Weitzel RP, Eckhaus MA, Tisdale JF, Yachie A, Rouault TA. (2014) Wild-type macrophages reverse disease in heme oxygenase 1-deficient mice. Blood 124(9):1522-30. PMID: 24963040, DOI: 10.1182/blood-2014-02-554162
Frey AG, Nandal A, Park JH, Smith PM, Yabe T, Ryu MS, Ghosh MC, Lee J, Rouault TA, Park MH, Philpott CC. (2014) Iron chaperones PCBP1 and PCBP2 mediate the metallation of the dinuclear iron enzyme deoxyhypusine hydroxylase. Proc Natl Acad Sci USA 111(22):8031-6. PMID: 24843120, DOI: 10.1073/pnas.1402732111
Kosmidis S, Missirlis F, Botella JA, Schneuwly S, Rouault TA, Skoulakis EM. (2014) Behavioral decline and premature lethality upon pan-neuronal ferritin overexpression in Drosophila infected with a virulent form of Wolbachia. Front Pharmacol 5:66. PMID: 24772084, DOI: 10.3389/fphar.2014.00066
Maio N, Singh A, Uhrigshardt H, Saxena N, Tong WH, Rouault TA. (2014) Cochaperone binding to LYR motifs confers specificity of iron sulfur cluster delivery. Cell Metab 19(3):445-57. PMID: 24606901, DOI: 10.1016/j.cmet.2014.01.015
Crooks DR, Natarajan TG, Jeong SY, Chen C, Park SY, Huang H, Ghosh MC, Tong WH, Haller RG, Wu C, Rouault TA. (2014) Elevated FGF21 secretion, PGC-1α and ketogenic enzyme expression are hallmarks of iron-sulfur cluster depletion in human skeletal muscle. Hum Mol Genet 23(1):24-39. PMID: 23943793, DOI: 10.1093/hmg/ddt393

2013

Yang Y, Lane AN, Ricketts CJ, Sourbier C, Wei MH, Shuch B, Pike L, Wu M, Rouault TA, Boros LG, Fan TW, Linehan WM. (2013) Metabolic reprogramming for producing energy and reducing power in fumarate hydratase null cells from hereditary leiomyomatosis renal cell carcinoma. PLoS One 8(8):e72179. PMID: 23967283, DOI: 10.1371/journal.pone.0072179
Rouault TA. (2013) Iron metabolism in the CNS: implications for neurodegenerative diseases. Nat Rev Neurosci 14(8):551-64. PMID: 23820773, DOI: 10.1038/nrn3453
Lim SC, Friemel M, Marum JE, Tucker EJ, Bruno DL, Riley LG, Christodoulou J, Kirk EP, Boneh A, DeGennaro CM, Springer M, Mootha VK, Rouault TA, Leimkühler S, Thorburn DR, Compton AG. (2013) Mutations in LYRM4, encoding iron-sulfur cluster biogenesis factor ISD11, cause deficiency of multiple respiratory chain complexes. Hum Mol Genet 22(22):4460-73. PMID: 23814038, DOI: 10.1093/hmg/ddt295
Linehan WM, Rouault TA. (2013) Molecular pathways: Fumarate hydratase-deficient kidney cancer—targeting the Warburg effect in cancer. Clin Cancer Res 19(13):3345-52. PMID: 23633457, DOI: 10.1158/1078-0432.CCR-13-0304
Uhrigshardt H, Rouault TA, Missirlis F. (2013) Insertion mutants in Drosophila melanogaster Hsc20 halt larval growth and lead to reduced iron-sulfur cluster enzyme activities and impaired iron homeostasis. J Biol Inorg Chem 18(4):441-9. PMID: 23444034, DOI: 10.1007/s00775-013-0988-2
Ghosh MC, Zhang DL, Jeong SY, Kovtunovych G, Ollivierre-Wilson H, Noguchi A, Tu T, Senecal T, Robinson G, Crooks DR, Tong WH, Ramaswamy K, Singh A, Graham BB, Tuder RM, Yu ZX, Eckhaus M, Lee J, Springer DA, Rouault TA. (2013) Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2α. Cell Metab 17(2):271-81. PMID: 23395173, DOI: 10.1016/j.cmet.2012.12.016

2012

Sourbier C, Srivastava G, Ghosh MC, Ghosh S, Yang Y, Gupta G, Degraff W, Krishna MC, Mitchell JB, Rouault TA, Linehan WM. (2012) Targeting HIF2α translation with Tempol in VHL-deficient clear cell renal cell carcinoma. Oncotarget 3(11):1472-82. PMID: 23178531, DOI: 10.18632/oncotarget.561
Xia H, Cao Y, Dai X, Marelja Z, Zhou D, Mo R, Al-Mahdawi S, Pook MA, Leimkühler S, Rouault TA, Li K. (2012) Novel frataxin isoforms may contribute to the pathological mechanism of Friedreich ataxia. PLoS One 7(10):e47847. PMID: 23082224, DOI: 10.1371/journal.pone.0047847
Crooks DR, Jeong SY, Tong WH, Ghosh MC, Olivierre H, Haller RG, Rouault TA. (2012) Tissue specificity of a human mitochondrial disease: differentiation-enhanced mis-splicing of the Fe-S scaffold gene ISCU renders patient cells more sensitive to oxidative stress in ISCU myopathy. J Biol Chem 287(48):40119-30. PMID: 23035118, DOI: 10.1074/jbc.M112.418889
Kwan JY, Jeong SY, Van Gelderen P, Deng HX, Quezado MM, Danielian LE, Butman JA, Chen L, Bayat E, Russell J, Siddique T, Duyn JH, Rouault TA, Floeter MK. (2012) Iron accumulation in deep cortical layers accounts for MRI signal abnormalities in ALS: correlating 7 tesla MRI and pathology. PLoS One 7(4):e35241. PMID: 22529995, DOI: 10.1371/journal.pone.0035241
Rouault TA. (2012) Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease. Dis Model Mech 5(2):155-64. PMID: 22382365, DOI: 10.1242/dmm.009019
Shi Y, Ghosh M, Kovtunovych G, Crooks DR, Rouault TA. (2012) Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis. Biochim Biophys Acta 1823(2):484-92. PMID: 22101253, DOI: 10.1016/j.bbamcr.2011.11.002

2011

Jeong SY, Crooks DR, Wilson-Ollivierre H, Ghosh MC, Sougrat R, Lee J, Cooperman S, Mitchell JB, Beaumont C, Rouault TA. (2011) Iron insufficiency compromises motor neurons and their mitochondrial function in Irp2-null mice. PLoS One 6(10):e25404. PMID: 22003390, DOI: 10.1371/journal.pone.0025404
Cameron JM, Janer A, Levandovskiy V, Mackay N, Rouault TA, Tong WH, Ogilvie I, Shoubridge EA, Robinson BH. (2011) Mutations in iron-sulfur cluster scaffold genes NFU1 and BOLA3 cause a fatal deficiency of multiple respiratory chain and 2-oxoacid dehydrogenase enzymes. Am J Hum Genet 89(4):486-95. PMID: 21944046, DOI: 10.1016/j.ajhg.2011.08.011
Tong WH, Sourbier C, Kovtunovych G, Jeong SY, Vira M, Ghosh M, Romero VV, Sougrat R, Vaulont S, Viollet B, Kim YS, Lee S, Trepel J, Srinivasan R, Bratslavsky G, Yang Y, Linehan WM, Rouault TA. (2011) The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels. Cancer Cell 20(3):315-27. PMID: 21907923, DOI: 10.1016/j.ccr.2011.07.018
Zhang DL, Senecal T, Ghosh MC, Ollivierre-Wilson H, Tu T, Rouault TA. (2011) Hepcidin regulates ferroportin expression and intracellular iron homeostasis of erythroblasts. Blood 118(10):2868-77. PMID: 21700773, DOI: 10.1182/blood-2011-01-330241
Kosmidis S, Botella JA, Mandilaras K, Schneuwly S, Skoulakis EM, Rouault TA, Missirlis F. (2011) Ferritin overexpression in Drosophila glia leads to iron deposition in the optic lobes and late-onset behavioral defects. Neurobiol Dis 43(1):213-9. PMID: 21440626, DOI: 10.1016/j.nbd.2011.03.013

2010

Shi ZH, Nie G, Duan XL, Rouault T, Wu WS, Ning B, Zhang N, Chang YZ, Zhao BL. (2010) Neuroprotective mechanism of mitochondrial ferritin on 6-hydroxydopamine-induced dopaminergic cell damage: implication for neuroprotection in Parkinson's disease. Antioxid Redox Signal 13(6):783-96. PMID: 20121342, DOI: 10.1089/ars.2009.3018
Cohen LA, Gutierrez L, Weiss A, Leichtmann-Bardoogo Y, Zhang DL, Crooks DR, Sougrat R, Morgenstern A, Galy B, Hentze MW, Lazaro FJ, Rouault TA, Meyron-Holtz EG. (2010) Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway. Blood 116(9):1574-84. PMID: 20472835, DOI: 10.1182/blood-2009-11-253815
Ye H, Rouault TA. (2010) Erythropoiesis and iron sulfur cluster biogenesis. Adv Hematol pii: 329394. PMID: 20862391, DOI: 10.1155/2010/329394
Bullock GC, Delehanty LL, Talbot AL, Gonias SL, Tong WH, Rouault TA, Dewar B, Macdonald JM, Chruma JJ, Goldfarb AN. (2010) Iron control of erythroid development by a novel aconitase-associated regulatory pathway. Blood 16(1):97-108. PMID: 20407036, DOI: 10.1182/blood-2009-10-251496
Ye H and Rouault TA. (2010) Human Iron-Sulfur Cluster Assembly, Cellular Iron Homeostasis, and Disease. Biochemistry 49(24):4945-56. PMID: 20481466, DOI: 10.1021/bi1004798
Crooks DR, Ghosh MC, Haller RG, Tong W-H, and Rouault TA. (2010) Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery. Blood 115(4):860-9. PMID: 19965627, DOI: 10.1182/blood-2009-09-243105
Ye H, Jeong SY, Ghosh MC, Kovtunovych G, Silvestri L, Danilo Ortillo, Uchida Naoya, Camaschella C, and Rouault TA. (2010) Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts. J Clin Invest 120(5):1749-61. PMID: 20364084, DOI: 10.1172/JCI40372
Kovunovych G, Eckhaus MA, Ghosh MC, Ollivierre-Wilson H, and Rouault TA. (2010) Dysfunction of the heme recycling system in heme oxygenase 1 deficient mice: effects on macrophage viability and tissue iron distribution. Blood 116(26):6054-62. PMID: 20844238, DOI: 10.1182/blood-2010-03-272138
Li K, Singh A, Crooks DR, Dai X, Cong Z, Pan L, Ha D, and Rouault TA. (2010) Expression of Human Frataxin Is Regulated by Transcription Factors SRF and TFAP2. PLoS One 5(8):e12286. PMID: 20808827, DOI: 10.1371/journal.pone.0012286
Uhrigshardt H, Singh A, Kovtunovych G, Ghosh M, and Rouault TA. (2010) Characterization of the human HSC20, an unusual DnaJ type III protein, involved in iron–sulfur cluster biogenesis. Hum Mol Genet 19(19):3816-34. PMID: 20668094, DOI: 10.1093/hmg/ddq301

2009

Rouault TA. (2009) An Ancient Gauge for Iron Science 326(5953):676-677. PMID: 19900922, DOI: 10.1126/science.1181938
Zhang DL, Hughes RM, Ollivierre-Wilson H, Ghosh MC, Rouault TA. (2009) A ferroportin transcript that lacks an iron-responsive element enables duodenal and erythroid precursor cells to evade translational repression. Cell Metab 9(5):461-73. PMID: 19416716, DOI: 10.1016/j.cmet.2009.03.006
Rouault TA, Zhang DL, Jeong SY. (2009) Brain iron homeostasis, the choroid plexus, and localization of iron transport proteins. Metab Brain Dis 24(4):673-84. PMID: 19851851, DOI: 10.1007/s11011-009-9169-y
Rouault TA, Tong WH. (2009) Tangled up in red: intertwining of the heme and iron-sulfur cluster biogenesis pathways. Cell Metab 10(2):80-1. PMID: 19656484, DOI: 10.1016/j.cmet.2009.07.007
Shi Y, Ghosh MC, Tong WH, Rouault TA. (2009) Human ISD11 is essential for both iron-sulfur cluster assembly and maintenance of normal cellular iron homeostasis. Hum Mol Genet 18(16):3014-25. PMID: 19454487, DOI: 10.1093/hmg/ddp239

2008

Ghosh MC, Tong WH, Zhang D, Ollivierre-Wilson H, Singh A, Krishna MC, Mitchell JB, Rouault TA. (2008) Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice. Proc Natl Acad Sci USA 105(33):12028-33. PMID: 18685102, DOI: 10.1073/pnas.0805361105
Rouault TA, Tong WH. (2008) Iron-sulfur cluster biogenesis and human disease. Trends Genet 24(8):398-407. PMID: 18606475, DOI: 10.1016/j.tig.2008.05.008
Li K, Besse EK, Ha D, Kovtunovych G, Rouault TA. (2008) Iron-dependent regulation of frataxin expression: implications for treatment of Friedreich ataxia. Hum Mol Genet 17(15):2265-73. PMID: 18424449, DOI: 10.1093/hmg/ddn127
Mochel F, Knight MA, Tong WH, Hernandez D, Ayyad K, Taivassalo T, Andersen PM, Singleton A, Rouault TA, Fischbeck KH, Haller RG. (2008) Splice mutation in the iron-sulfur cluster scaffold protein ISCU causes myopathy with exercise intolerance. Am J Hum Genet 82(3):652-60. PMID: 18304497, DOI: 10.1016/j.ajhg.2007.12.012

2007

Missirlis F, Kosmidis S, Brody T, Mavrakis M, Holmberg S, Odenwald WF, Skoulakis EM, Rouault TA. (2007) Homeostatic mechanisms for iron storage revealed by genetic manipulations and live imaging of Drosophila ferritin. Genetics 177(1):89-100. PMID: 17603097, DOI: 10.1534/genetics.107.075150
Babady NE, Carelle N, Wells RD, Rouault TA, Hirano M, Lynch DR, Delatycki MB, Wilson RB, Isaya G, Puccio H. (2007) Advancements in the pathophysiology of Friedreich's Ataxia and new prospects for treatments. Mol Genet Metab 92(1-2):23-35. PMID: 17596984, DOI: 10.1016/j.ymgme.2007.05.009
Crooks DR, Ghosh MC, Braun-Sommargren M, Rouault TA, Smith DR. (2007) Manganese targets m-aconitase and activates iron regulatory protein 2 in AF5 GABAergic cells. J Neurosci Res 85(8):1797-809. PMID: 17469137, DOI: 10.1002/jnr.21321
Zhang, D., Meyron-Holtz, E. and Rouault, T.A. (2007) Renal Iron Metabolism: Transferrin Iron Delivery and the Role of Iron Regulatory Proteins. J Am Soc Nephrol 18(2):401-6. PMID: 17229905, DOI: 10.1681/ASN.2006080908
Tong, W.H. and Rouault, T.A. (2007) Metabolic regulation of citrate and iron by aconitases: role of iron–sulfur cluster biogenesis. Biometals 20(3-4):549-64. PMID: 17205209, DOI: 10.1007/s10534-006-9047-6

2006

Rouault, T.A. (2006) If the RNA fits, use it. Science 314(5807):1886-7. PMID: 17185590, DOI: 10.1126/science.1137174
Rouault, T.A. and Cooperman, S. (2006) Brain Iron Metabolism. Semin Pediatr Neurol 13(3):142-8. PMID: 17101452, DOI: 10.1016/j.spen.2006.08.002
Rouault, T.A. (2006) The role of iron regulatory proteins in mammalian iron homeostasis and disease. Nat Chem Biol 2(8):406-14. PMID: 16850017, DOI: 10.1038/nchembio807
Smith S.R., Ghosh M.C., Ollivierre-Wilson, H., Tong, W.H., Rouault T.A. (2006) Complete loss of iron regulatory proteins 1 and 2 prevents viability of murine zygotes beyond the blastocyst stage of embryonic development. Blood Cells Mol Dis 36(2):283-7. PMID: 16480904, DOI: 10.1016/j.bcmd.2005.12.006
Li K., Tong W.H., Hughes R.M., Rouault T.A. (2006) Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU in iron-sulfur cluster assembly. J Biol Chem 281(18):12344-51. PMID: 16527810, DOI: 10.1074/jbc.M600582200
Tong W.H., Rouault, T.A. (2006) Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis. Cell Metab 3(3):199-210. PMID: 16517407, DOI: 10.1016/j.cmet.2006.02.003

2005

Wang, R.H., Li, C. Xu X., Zheng Y., Xiao, C., Zerfas, P., Cooperman, S., Eckhaus, M., Rouault, T.A., Mishra, L., Deng C.X. (2005) A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab 2(6):399-409. PMID: 16330325, DOI: 10.1016/j.cmet.2005.10.010
Rouault, T.A. (2005) The intestinal heme transporter revealed. Cell 122(5):649-51. PMID: 16143096, DOI: 10.1016/j.cell.2005.08.027
Rouault, T.A. (2005) Linking Physiological functions of iron. Nat Chem Biol 1(4):193-4. PMID: 16408033, DOI: 10.1038/nchembio0905-193
Cooperman, S.S., Meyron-Holtz, E.G., Olivierre-Wilson, H., Ghosh, M.C., McConnell, J.P., Rouault, T.A. (2005) Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2. Blood 106(3):1084-91. PMID: 15831703, DOI: 10.1182/blood-2004-12-4703
Yikilmaz E., Rouault T.A., Schuck, P. (2005) Self-Associated and Ligand-Induced Conformational Changes of Iron Regulatory Proteins 1 and 2. Biochemistry 44(23):8470-8. PMID: 15938636, DOI: 10.1021/bi0500325
Zhang P., Land W., Lee S., Juliani J., Lefman J., Smith S. R., Germain D., Kessel M., Leapman R., Rouault T.A., Subramaniam S. (2005) Electron tomography of degenerating neurons in mice with abnormal regulation of iron metabolism. J Struct Biol 150(2):144-53. PMID: 15866737, DOI: 10.1016/j.jsb.2005.01.007
Rouault, T.A., Tong W.H. (2005) Opinion: Iron-sulphur cluster biogenesis and mitochondrial iron homeostasis. Nat Rev Mol Cell Biol 6(4):345-51. PMID: 15803140, DOI: 10.1038/nrm1620

2004

Meyron-Holtz, E.G., Ghosh, M.C., Rouault, T.A. (2004) Mammalian tissue oxygen levels modulate iron-regulatory protein activities in vivo. Science 306(5704):2087-90. PMID: 15604406, DOI: 10.1126/science.1103786
Rouault, T.A. (2004) Pathogenic bacteria prefer heme. Science 305(5690):1577-8. PMID: 15361615, DOI: 10.1126/science.1102975
Smith, S.R., Cooperman, S., Lavaute, T., Tresser, N., Ghosh, M. Meyron-Holtz, E., Land, W., Ollivierre, H., Jortner, B., Switzer, R., Messing, A., Rouault, T.A. (2004) Severity of neurodegeneration correlates with compromise of iron metabolism in mice with iron regulatory protein deficiencies. Ann NY Acad Sci 1012:65-83. PMID: 15105256, DOI: 10.1196/annals.1306.006
Wu, L.J., Leenders, A.G.M., Cooperman, S., Meyron-Holtz, E., Smith, S., Land, W., Tsai, R.Y.L., Berger, U.V., Sheng, Z.H., Rouault, T.A. (2004) Expression of the iron transporter ferroportin in synaptic vesicles and the blood-brain barrier. Brain Res 1001(1-2):108-17. PMID: 14972659, DOI: 10.1016/j.brainres.2003.10.066
Meyron-Holtz, E.G., Ghosh, M.C., Iwai, K., LaVaute, T., Brazzolotto, X., Berger, U.V., Land, W., Ollivierre-Willson, H., Grinberg, A., Love, P., Rouault, T.A. (2004) Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis. EMBO J 23(2):386-95. PMID: 14726953, DOI: 10.1038/sj.emboj.7600041

2003

Allerson, C.R., Martinez, A., Yikilmaz, E., Rouault, T.A. (2003) A high-capacity RNA affinity column for the purification of human IRP1 and IRP2 overexpressed in Pichia pastoris. RNA 9(3):364-74. PMID: 12592010, DOI: 10.1261/rna.2143303
Bourdon, E., Kang, D.K., Ghosh, M.C., Drake, S.K., Wey, J., Levine, R.L., and Rouault, T.A. (2003) The role of endogenous heme synthesis and degradation domain cysteines in cellular iron-dependent degradation of IRP2. Blood Cells Mol Dis 31(2):247-55. PMID: 12972033
Tong, W.H., Jameson, G.N.L., Huynh, B.H., and Rouault, T.A. (2003) Subcellular compartmentalization of human Nfu, an iron-sulfur cluster scaffold protein, and its ability to assemble a [4Fe-4S] cluster. Proc Natl Acad Sci USA 100(17):9762-7. PMID: 12886008, DOI: 10.1073/pnas.1732541100
Grabill, A., Silva, A.C., Smith, S.S., Koretsky, A.P., Rouault, T.A. (2003) MRI detection of ferritin iron overload and associated neuronal pathology in iron regulatory protein-2 knockout mice. Brain Res 971(1):95-106. PMID: 12691842, DOI: 10.1016/s0006-8993(03)02366-7

2002

Drake, S.K., Bourdon, E., Wehr, N.B., Levine, R.L., Backlund, P. S., Yergey, A.L., Rouault, T.A. (2002) Numerous proteins in Mammalian cells are prone to iron-dependent oxidation and proteasomal degradation. Dev Neurosci 24(2-3):114-24. PMID: 12401949, DOI: 10.1159/000065693

2001

Rouault T.A. (2001) Iron on the brain. Nat Genet 28(4):299-300. PMID: 11479580, DOI: 10.1038/91036
LaVaute, T., Smith, S., Cooperman, S., Iwai, K., Land, W., Meyron-Holtz, E., Drake, S.K. Miller, G., Abu-Asab, M., Tsokos, M., Switzer III, R., Grinberg, A, Love, P., Tresser, N., Rouault, T.A. (2001) Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat Genet 27(2):209-14. PMID: 11175792, DOI: 10.1038/84859

1997

Addess, K.J., Basilion, J.P., Klausner, R.D., Rouault, T.A., and Pardi, A.J. (1997) Structure and dynamics of the iron responsive element RNA: implications for binding of the RNA by iron regulatory binding proteins. J Mol Biol 274(1):72-83. PMID: 9398517, DOI: 10.1006/jmbi.1997.1377
Rouault, T., and Klausner, R. (1997) Regulation of iron metabolism in eukaryotes. Curr Top Cell Regul 35:1-19. PMID: 9192174

1996

Butt, J., Kim, H.Y., Basilion, J.P., Cohen, S., Iwai, K., Philpott, C. C., Altschul, S., Klausner, R.D., and Rouault, T.A. (1996) Differences in the RNA binding sites of iron regulatory proteins and potential target diversity. Proc Natl Acad Sci USA 93(9):4345-9. PMID: 8633068, DOI: 10.1073/pnas.93.9.4345
Kim, H. Y., LaVaute, T., Iwai, K., Klausner, R.D., and Rouault, T.A. (1996) Identification of a conserved and functional iron-responsive element in the 5'UTR of mammalian mitochondrial aconitase. J Biol Chem 271(39):24226-24230. PMID: 8798666, DOI: 10.1074/jbc.271.39.24226
Rouault, T.A., and Klausner, R.D. (1996) Iron-sulfur clusters as biosensors of oxidants and iron. Trends Biochem Sci 21(5):174-7. PMID: 8871401
Rouault T, Klausner R, Harford J. 1996. Translational Control of Ferritin. In: Hershey J, Mathews M, Sonenberg N, ed. by. Translational Control. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. p. 335-362. DOI: 10.1101/087969458.30.335
Rouault, T.A., and Klausner, R.D. (1996) Post-transcriptional regulation of genes of iron metabolism in mammalian cells. J Bioinorganic Chem 1:494-498. DOI: 10.1007/s007750050083

1995

Iwai, K., Klausner, R.D., and Rouault, T.A. (1995) Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2. EMBO J 14(21):5350-7. PMID: 7489724
Kim, H.Y., Klausner, R.D., and Rouault, T.A. (1995) Translational repressor activity is equivalent and is quantitatively predicted by in vitro RNA binding for two iron-responsive element binding proteins, IRP1 and IRP2. J Biol Chem 270(10):4983-6. PMID: 7890603, DOI: 10.1074/jbc.270.10.4983

1994

Basilion, J.P., Rouault, T.A., Massinople, C.M., Klausner, R.D., and Burgess, W.H. (1994) The iron-responsive element-binding protein: Localization of the RNA binding site to the aconitase active-site cleft. Proc Natl Acad Sci USA 91(2):574-8. PMID: 8290565, DOI: 10.1073/pnas.91.2.574
Philpott, C.C., Klausner, R.D., and Rouault, T.A. (1994) The bifunctional iron-responsive element binding protein/cytosolic aconitase: The role of active-site residues in ligand binding and regulation. Proc Natl Acad Sci USA 91(15):7321-5. PMID: 8041788, DOI: 10.1073/pnas.91.15.7321
Samaniego, F., Chin, J., Iwai, K., Rouault, T.A., and Klausner, R.D. (1994) Molecular Characterization of a Second Iron Responsive Element Binding Protein, Iron Regulatory Protein 2 (IRP2): Structure, Function and Post-translational Regulation. J Biol Chem 269(49):30904-10. PMID: 7983023

1993

Klausner, R.D., and Rouault, T.A. (1993) A Double Life: Cytosolic aconitase as a regulatory RNA binding protein. Mol Biol Cell 4(1):1-5. PMID: 8443405, DOI: 10.1091/mbc.4.1.1
Klausner, R.D., Rouault, T.A., and Harford, J.B. (1993) Regulating the fate of mRNA: the control of cellular iron metabolism. Cell 72(1):19-28. PMID: 8380757, DOI: 10.1016/0092-8674(93)90046-s

1990

Rouault, T.A., Tang, C.K., Kaptain, S., Burgess, W.H., Haile, D.J., Samaniego, F., McBride, O.W., Harford, J.B., and Klausner, R.D. (1990 Oct) Cloning of the cDNA encoding an RNA regulatory protein—the human iron-responsive element-binding protein. Proc Natl Acad Sci USA 87(20):7958-62. PMID: 2172968, DOI: 10.1073/pnas.87.20.7958

1989

Rouault, T.A., Hentze, M.W., Haile, D.J., Harford, J.B., and Klausner, R.D. (1989) The iron-responsive element binding protein: a method for the affinity purification of a regulatory RNA-binding protein. Proc Natl Acad Sci USA 86(15):5768-72. PMID: 2474819, DOI: 10.1073/pnas.86.15.5768

1988

Rouault, T.A., Hentze, M.W., Caughman, S.W., Harford, J.B., and Klausner, R.D. (1988) Binding of a cytosolic protein to the iron-responsive element of human ferritin messenger RNA. Science 241(4870):1207-10. PMID: 3413484, DOI: 10.1126/science.3413484