An NIH-funded study suggests that fenoprofen may be a potential therapeutic for endometriosis, a disease that affects approximately 1 in 10 U.S. women. The researchers used a computer algorithm to evaluate nearly 1,300 existing drugs and tested their top candidate, fenoprofen, in a rodent model of the disease.
News
NICHD issues News Releases and Media Advisories to the news media. Spotlight and Research Feature articles explain NICHD research findings and public health issues to the general public. An Item of Interest is a short announcement of relevant information, such as a notable staff change.
Item of Interest: NIH-funded research leads to fluconazole labeling updates for use in infants
Health care providers often use the antifungal drug fluconazole “off-label” to prevent and treat fungal infections in infants. Thanks to NICHD-funded research, fluconazole labels now include information about the drug’s recommended usage and dosage in infants, including those born prematurely.
Director's Corner: Elucidating the Effects of Digital Media on Children
NICHD has a longstanding commitment to research on the effects of exposure to and use of technology and digital media from infancy through adolescence. Since 2020, the Institute has expanded its research in this area to advance toward the goal of discovering how such exposure and use affect developmental trajectories, health outcomes, and parent-child interactions in early childhood.
Spotlight: NIH Panel Explores Endometriosis Advances, Emphasizes Awareness
Around 200 million people worldwide live with endometriosis, a common gynecological disease with symptoms that include pelvic pain, fatigue, and infertility. NICHD recently hosted a discussion about advances and new directions in endometriosis research, and the imperative of raising awareness and education about the disease.
Release: Children Surpass a Year of HIV Remission after Treatment Pause
Four children enrolled in an NIH-funded study have remained free of detectable HIV for more than one year after their antiretroviral therapy was paused to see if they could achieve HIV remission, researchers report. The findings suggest that very early HIV treatment enables unique features of the neonatal immune system to limit HIV reservoir development, increasing the prospect of HIV remission.
Item of Interest: NIH awards interim prizes in fetal diagnostic and monitoring technology competition
NIH has announced finalists in its competition to accelerate the development of diagnostic and monitoring
technologies to improve fetal health outcomes.
Science Update: Placental particles in maternal bloodstream may signal less fetal growth, NIH-funded study suggests
Tiny, balloon-like particles released from the placenta could provide clues to identify fetuses at risk for growth restriction early so that pregnancies could be monitored for complications.
Science Update: Timing of COVID-19 vaccination drives menstrual cycle changes, NIH-funded study suggests
People who receive a COVID-19 vaccine during the first half of the menstrual cycle are more likely to experience a small, temporary increase in cycle length than those vaccinated during the second half, suggests an NICHD-funded study. By providing additional information about what to expect after a COVID-19 vaccine, the findings may help ease fears and anxiety around vaccination.
Science Update: Omega-3 supplements may reduce schizotypal personality symptoms, NIH-funded study suggests
Taking an omega-3 fatty acid supplement lowered children’s scores for schizotypal personality disorder, which features unusual thoughts, speech, and behaviors that hinder the ability to form relationships. The results suggest that regular supplementation in childhood could prevent more severe symptoms from developing in adolescence.
Director's Corner: Preventing Sexually Transmitted Infections
There were more than 2.5 million cases of syphilis, gonorrhea, and chlamydia in the United States in 2022. NICHD research aims to prevent these and other sexually transmitted infections (STIs) among women, infants, children, and adolescents. Focus areas include addressing the need for additional STI prevention methods for women and curbing the rise in congenital syphilis cases.
Spotlight: Women in Science: Dr. Tracey Rouault on Resilience
NICHD’s Tracey Rouault, M.D., has had many notable achievements during her nearly four-decade career in the intramural program at NIH. Learn about her upbringing, career path, and accomplishments.
Science Update: Positive parenting may counteract children’s biological aging in the face of adversity, NIH-funded study suggests
Positive parenting practices, like praising, noticing, and encouraging children’s behavior, may help reduce the faster rate of biological aging seen in children under adverse conditions. Such positive parenting practices may counter the effects of children’s hardships, improving their long-term physical and psychological health.
Science Update: Preterm infants fed donor milk had fewer intestinal complications than formula-fed infants
Compared to formula fed infants, extremely preterm infants fed donated human milk had half the rate of necrotizing enterocolitis, a life threatening condition of the intestines. There were no differences in neurological development between those fed donor milk and those fed formula.
Science Update: Preterm infants protected by maternal COVID-19 vaccination, NIH-funded study suggests
Preterm infants born to people who have been vaccinated for COVID-19 had roughly the same levels of antibodies to the spike protein of SARS-CoV-2 as term infants born to vaccinated people, allaying concerns that fewer antibodies might pass to preterm infants.
Science Update: Step monitoring and coaching more effective at improving physical activity after stroke than traditional therapy, NIH-funded study suggests
A step monitoring program for stroke survivors is more effective at spurring long-term physical activity than the traditional therapy of high-intensity walking. The step program appears to reduce the chances that stroke survivors will become sedentary after their therapy is complete, which increases the risk for future strokes.
Science Update: NIH-funded study suggests best ways to screen for sepsis during and after pregnancy
Sepsis screening tools designed to account for the physiological changes that may occur during pregnancy perform best from 20 weeks of pregnancy through 3 days postpartum, research suggests. In early pregnancy and later in the postpartum period, tools based on general sepsis screening criteria may more accurately predict which patients are at high risk for maternal sepsis, a leading cause of pregnancy-related deaths.
Media Advisory: NIH-supported researchers create single-cell atlas of the placenta during term labor
An atlas of the placenta developed by NIH researchers offers insight on the communication that occurs between maternal and fetal cells during labor and delivery.
Science Update: NIH-funded researchers link genetic variants to malformations in stillborn infants
Researchers linked malformations in stillborn infants to copy number variants—lengths of DNA in which hereditary material is duplicated or deleted. What they learned could lead provide information helpful to parents and for pregnancy care.
Science Update: Altered fluid channels in the brain may be linked to diagnosis of autism spectrum disorder, NIH-funded study suggests
Children with enlarged perivascular spaces—fluid-filled cavities surrounding the brain’s small blood vessels—had a higher risk for developing autism spectrum disorder and later sleep problems. Brain scans to detect the enlargement could be helpful for obtaining an earlier diagnosis of autism spectrum disorders.
Science Update: Questionnaire could identify emotional responses leading to PTSD after childbirth, NIH-funded study suggests
A questionnaire detecting strong emotional responses to traumatic births could help identify new mothers at risk for developing childbirth-related post-traumatic stress disorder. It may lead to faster diagnosis—and treatment—of post traumatic stress disorder in new mothers.