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Item of Interest: Gene Variations that Alter Key Enzyme Linked to Prostate Cancer

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November 16, 2010

Recently, researchers at the National Institutes of Health reported that variations in a gene for an enzyme involved in cell energy metabolism appear to increase the risk for prostate cancer.

The genetic variations all impair the enzyme phosphodiesterase 11A (PDE11A), which helps regulate a cell's responses to hormones and other signals. Previous studies by this group have linked genetic variations that inactivate PDE11A with increased susceptibility to testicular cancer and adrenal tumors.

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Last Reviewed: 11/19/2010

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Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology