November 16, 2010
Recently, researchers at the National Institutes of Health reported that variations in a gene for an enzyme involved in cell energy metabolism
appear to increase the risk for prostate cancer.
The genetic variations all impair the enzyme phosphodiesterase 11A (PDE11A), which helps regulate a cell's responses to hormones and other signals. Previous studies by this group have linked genetic variations that inactivate PDE11A with
increased susceptibility to testicular cancer and
Key Enzyme Gene Variations Linked to Prostate Cancer text alternative.
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): The NICHD sponsors research on development, before and after birth; maternal, child, and family health; reproductive biology and population issues; and medical rehabilitation. For more information, visit the Institute's Web site at
The National Institutes of Health (NIH) —
The Nation's Medical Research Agency — includes 27 Institutes and Centers and is a component of the U. S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical, and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit