The NICHD conducts and supports a variety of clinical research related to PCOS. Select a link below to learn more about these projects.
Featured NICHD Clinical Trials
- Ovarian Morphology and Theca Cell Androgen Production in PCOS
Women with PCOS have more follicles and androgen producing cells. This study aims to determine whether the size and number of ovarian follicles correlate to androgen production in women with or without PCOS.
Acute effects of progesterone on LH pulses during the follicular phase
The purpose of this study is to determine if progesterone slows LH pulse frequency, using a randomized, cross-over, placebo-controlled study.
Endometrial effects of metformin action in women with Polycystic Ovarian Syndrome (PCOS)
The goal of this study is to determine if improving insulin sensitivity with use of metformin in women with PCOS has facilitatory influences on the uterine endometrium.
The genetics of polycystic ovarian syndrome
This study will evaluate the genetic basis of PCOS.
Effect of high testosterone on sleep-associated slowing of follicular luteinizing hormone (LH) frequency in polycystic ovary syndrome
The purpose of this study is to determine whether a testosterone receptor blocker (flutamide) will normalize sleep-wake luteinizing hormone pulse frequency relationships in women with PCOS.
Blood vessel function in adolescents and women with polycystic ovary syndrome
This research study will help determine if women with PCOS have early changes in their blood vessels, and if the number of progenitor cells are related to these blood vessel changes.
Effect of weight and insulin sensitivity on reproductive function in PCOS (PULSE)
This study will use dietary restriction, exercise training, and metformin, as well as no treatment, to determine the effects of weight loss and/or improved insulin sensitivity on reproductive function of obese women with PCOS.
Pharmacogenetics of metformin action in PCOS
This study explores whether genetic differences explain why some women with PCOS do not respond to metformin while other women do. Knowing whether a specific gene predicts the effect of metformin on ovulation would help make fertility treatments for PCOS more efficient and effective.
Adrenal hyperplasia among young people with PCOS
In some women with PCOS, high androgen levels have been associated with disorders of the adrenal glands, which are located on the top of the kidneys. In addition to androgens, the adrenal glands produce hormones that regulate the body's response to stress. This research aims to determine whether some women with PCOS have abnormalities in the adrenal glands or in their function that could contribute to PCOS.
NICHD Clinical Trials
ClinicalTrials.gov Search Results
Information on current NIH-sponsored clinical trials on PCOS is available by following the link below or by calling 800-411-1222.