Curriculum Vitae: Aiyi Liu, PhD

Senior Investigator and Acting Chief Biostatistics and Bioinformatics Branch
Division of Intramural Population Health Research (DIPHR)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
National Institutes of Health (NIH)
6710B Rockledge Dr., Room 3230, Bethesda, MD 20817

Telephones (301) 435-6952 (office)     (301) 825-2245 (cell)
Emails liua@mail.nih.gov

Education

  • B.S. in Mathematics (Statistics Major), 1986; M.S. in Statistics, 1988; Department of Mathematics, University of Science and Technology of China
  • Ph.D. in Statistics, Department of Statistics, University of Rochester, 1997

Training & Certificates

  • Postdoctoral Research Fellow, Department of Biostatistics and Epidemiology, St. Jude Children's Research Hospital, 1997-1999
  • Accreditation of Human Research Protection Programs, NIH
  • Leadership and Management Training, NIH

Academic/Research Appointments

  • Senior Investigator (with Tenure), 2007-Present, Investigator (Tenure Track), 2002-2007, Biostatistics and Bioinformatics Branch, DIPHR, NICHD, NIH
  • Adjunct Teaching Faculty, Department of Statistics, George Washington University, 2011- Present.
  • Adjunct faculty, 2004-Present; Assistant Professor of Biostatistics (Tenure Track), 1999- 2002, Department of Biostatistics, Bioinformatics and Biomathematics, Georgetown University
  • Faculty member, Department of Mathematics, University of Science and Technology of China, 1988-1993

Membership in Professional Societies

American Statistical Association, International Biometric Society (ENAR), International Chinese Statistical Association, International Indian Statistical Association, International Statistical Institute, Institute of Mathematical Statistics, and Korean International Statistical Society

Honors and Awards

  • Jiuzhang Mathematical Prize, University of Science and Technology of China, 1991
  • Graduate Fellowships, University of Rochester, 1993-1997
  • Time-Off Award in Recognition and Appreciation of Special Act or Service, NICHD, NIH, 2002
  • Elected member, International Statistical Institute, 2006
  • National Institutes of Health Merit Award, 2007, 2009
  • Fellow, American Statistical Association, 2011 ("For major contributions to sequential methods, especially in the area of statistical inference following sequential tests, for contributions to statistical research in diagnostic medicine, and for innovative applications of statistics to biomedical research")
  • National Institutes of Health Director's Award, 2013, 2015

Professional Service

  • Editorial Service
    • Associate Editor, Clinical Trials: Journal of the Society for Clinical Trials, 2014-Present
    • Associate Editor, Journal of Statistical Planning and Inference, 2009-2012
    • Guest Editor for "Mathematical and Statistical Methods for Diagnoses and Therapies". Philosophical Transaction of the Royal Society A, Number 1874, Volume 366, July 2008
    • Co-editor, "Applied Statistics in Biomedicine and Clinical Trials Design: Selected Papers from 2013 ICSA/ISBS Joint Statistical Meetings". Springer, New York, 2015.
    • Co-editor, special issue in honor of Dr. Greg Campbell's retirement. Journal of Biopharmaceutical Statistics 2016; 26
  • American Statistical Association (ASA)
    • Member, Committee on Award of an Outstanding Statistical Application, 2011- 2016
  • International Chinese Statistical Association (ASA)
    • President-Elect, 2017
    • Member, Awards Committee, 2015-2017
    • Member, Program Committee, Applied Statistics Symposium, 2016, 2011, 2005
    • Chair, Program Committee and Executive Committee, Applied Statistics Symposium, 2013
    • Member, Board of Directors, 2007-2009
  • Short Course Instructors at Conferences
    • "Evaluation of the Performance of Diagnostic Tests and Biomarkers Using ROC Analysis", Society for Clinical Trials (SCT) 35th Annual Meeting, Philadelphia, PA, May 2014
    • "Sequential Statistical Methods in the Design and Analysis of Clinical Trials", The 15th International Conference on Interdisciplinary Mathematical and Statistical Techniques, Shanghai, China, June 2007
  • Journal Referees
    • American Journal of Epidemiology, Biometrics, Biometrika, Biostatistics, Cancer Research, Communications in Statistics, Controlled Clinical Trials, Computational Statistics & Data Analysis, Epidemiology, Journal of Biopharmaceutical Statistics, Journal of Statistical Planning and Inference, Journal of the American Statistical Association, Journal of Multivariate Analysis, Medical and Pediatric Oncology, Pharmacotherapy, Statistics in Biosciences, Statistics in Biopharmaceutical Research, Statistics in Medicine, Statistics and Probability Letters, Statistical Science, Statistica Sinica
  • PhD Thesis Committee
    • Jiaquan Fan, Department of Statistics, George Washington University, March 2004
    • Dennis Buckman, Department of Statistics, George Washington University, June 2005
    • Liyi Jia, Department of Statistics, George Washington University, August 2016
    • Xing Chen, Department of Statistics, George Washington University, June 2016

Research Interest

  • General statistical theory and methods
  • Sequential and adaptive methods in clinical trials and biomedical research
  • Multivariate data analysis and related topics
  • Statistical methodology for diagnostic biomarkers (ROC curve analysis; methods for pooled biospecimens; evaluation of measurement errors; limit of detection and left truncation)
  • Semiparametric and nonparametric methods for multidimensional data
  • Genome-wide association studies
  • Group testing methodology
  • Precision medicine and prediction
  • Methods for semicontinuous data analysis

Teaching and Mentoring

  • Teaching
    • Department of Mathematics, University of Science and Technology of China, 1988- 1993. Teaching various undergraduate and graduate statistics courses, including "Statistics for Biological Sciences", "Linear Models and its Applications", and "Regression Analysis"
    • Department of Biostatistics, Bioinformatics and Biomathematics, Georgetown University, 1999-2002. Teaching "Mathematical Statistics" to students in the MS program of biostatistics, and participating lecture series, "Applied Biostatistics"
    • Department of Statistics, George Washington University. Teaching "Applied Multivariate Statistical Analysis" (Stat6215, graduate level), Fall 2011, Spring 2015; Teaching "Clinical Trials" (STAT6289-13, graduate level), Spring 2012, Fall 2015, Spring 2016, Fall 2016; Teaching "Regression Analysis" (STAT2118, graduate level), Spring 2013, Fall 2013
  • Postdoctoral Fellows
    • Chengqing Wu, University of Science and Technology of China, 2003-2007
    • Albert Vexler, Hebrew University, 2004-2007
    • Mixia Wu, Beijing University of Technology, 2006-2008
    • Catherine Chunling Liu, University of Hong Kong, 2008-2010
    • Yifan Wang (secondary mentor), State University of New York at Stony Brook, 2012-2014
    • Jared Foster, University of Michigan, 2013-2015
    • Wondwosen Kassahun Yimer, Hasselt University, Belgium, 2015-2017
    • Chi-Yang Chiu (secondary mentor), University of California at Davis, 2015-2017
    • Wei Zhang, Chinese Academy of Science, 2017-Present
  • PhD Students (Thesis Advisor)
    • Yu Shu, Department of Statistics, George Washington University o Mei Jin, Department of Statistics, George Washington University o Xian Sun, Department of Statistics, George Washington University
    • Jiang Hu, Department of Applied Mathematics and Statistics, the Johns Hopkins University
    • Xiaoyu Cai, Department of Statistics, George Washington University
    • Lixuan Yin (co-advisor), Department of Statistics, George Mason University
  • Master Students (Practicum Advisor)
    • Huisong Sun, Department of Biostatistics, Bioinformatics and Biomathematics, Georgetown University
    • Yina Zeng, Department of Biostatistics, Bioinformatics and Biomathematics, Georgetown University
  • Summer Students (at NIH)
    • Yan Zhu, University of Virginia, 2003
    • Helen Guo, Thomas Jefferson High School for Science and Technology, 2004
    • Elizabeth Schofield Dahlquist, University of South Florida, 2005
    • Ekaterina Eliseeva, University of Chicago, 2006
    • Helen Guo, University of Virginia, 2007
    • Xiaoshu Feng, University of Maryland, 2008
    • Angel Davalos, University of Texas-El Paso, 2009 o Robert Ashmead, The Ohio State University, 2011 o Le Chen, Gallaudet University, 2013
    • Gregory Haber, University of Maryland Baltimore County, 2014
    • Nicholas Sun, Columbia University
    • Eric Teoh (co-mentor), University of Alabama, 2002
    • Howard Bondell (co-mentor), Rutgers University, 2003

Services at NIH

  • Committee on Retreat, DIPHR, NICHD, 2002
  • Search Committee for Staff Scientist, DIPHR, NICHD, 2003
  • Judge for the Fellows Award for Research Excellence (FARE) 2005, Gene Expression Section
  • Search Committee for Statistician Staff Scientist – Facility Head Recruitment, Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, NIH, 2005, 2006
  • Search Committee member for tenure-track/tenured investigator, Epidemiology Branch, DIPHR, NICHD, 2006
  • Data Safety and Monitoring Board (DSMB) for "S.japonicum and Pregnancy Outcomes: A Randomized, Double Blind, Placebo Controlled Trial", National Institute of Allergy and Infectious Diseases, NIH, 2006
  • Ad hoc Reviewer, National Institute on Aging Board of Scientific Counselors' (BSC) Meeting, May, 2008
  • Member, Search Committee for Tenure-Track Investigators, DIPHR, NICHD, 2009
  • Member, Search Committee for Tenure-Track Investigators, DIPHR, NICHD, 2010
  • Member, Professional Development Committee, DIPHR, NICHD, 2010
  • Member, Institutional Review Board (IRB), NICHD, 2011-Present
  • Member, Search Committee for Tenure-Track Investigators, DIPHR, NICHD, 2012
  • Ad hoc Reviewer, National Institute on Aging Board of Scientific Counselors' (BSC) Meeting, May, 2012
  • Member, Search Committee for Staff Scientist, DIPHR, NICHD, 2013
  • Member, Mentoring Committee, DIPHR, NICHD, 2013-Present
  • Member, Tenure and Promotion Committee, DIPHR, NICHD, 2016-Present

Invited Presentations

  • "Secondary analysis following sequential clinical trials". Western Tennessee Chapter of ASA, Memphis, TN, April 1998
  • "Sequential tests and estimates after overrunning". Statistical Research Symposium in Honor of W. Jackson Hall's 70th Birthday. University of Rochester, Rochester, NY, September 1999
  • "Molecular classification of stage I breast cancer using gene microarray technology". International Chinese Statistical Association Applied Statistics Symposium, Piscataway, NJ, June 1999
  • "Sample size calculation for planning group sequential longitudinal trials". CDER, Food and Drug Administration (FDA), Rockville, MD, March 2000
  • "Analyzing data from a sequential clinical trial". Workshop on Current Advances in Interim Analysis and Design Modifications, CDER, Food and Drug Administration (FDA), Rockville, MD, September 2000
  • "Block principal component analysis with application to gene microarray data classification". Office of Biostatistics Research, National Heart Lung and Blood Institute, April 2003
  • "Unbiased estimation following a group sequential test for distributions in the exponential family". Department of Mathematics and Statistics, York University, Canada, November 2003
  • "Estimation following a multivariate group sequential test". International Chinese Statistical Association Applied Statistics Symposium, San Diego, CA, June 2004
  • "On linear combinations of biomarkers to improve diagnostic accuracy". Department of Epidemiology and Biostatistics, Medical University of South Carolina, September 2004
  • "On linear combinations of biomarkers to improve diagnostic accuracy". Division of Cancer Epidemiology and Genetics, National Cancer Institute, January 2005
  • "Estimation following a group sequential test for distributions in the one-parameter exponential family". Department of Mathematics, University of Maryland, February 2005
  • "Local maximization of linear combination of biomarkers to improve diagnostic accuracy". International Chinese Statistical Association Applied Statistics Symposium, Washington, DC, June 2005
  • "Sequential evaluation of time varying, non-transient treatment effects in clinical trials". International Biometric Society –WNAR/IMS Meeting, Fairbanks, Alaska, June 2005
  • "Estimation following a group sequential test for distributions in the one-parameter exponential family". Department of Statistics, George Washington University, September 2005
  • "Estimating rates at the termination of a group sequential phase II trial". Department of Statistics, University of Virginia, October 2005
  • "Estimation following a group sequential test for distributions in the one-parameter exponential family". Department of Mathematics and Statistics, McMaster University, Canada, February 2006
  • "Non-parametric sequential testing of the area under the ROC curves". International Biometric Society (ENAR) Spring Meeting, Tampa, FL, March 2006
  • "Multistage evaluation of measurement error in a reliability study". International Chinese Statistical Association Applied Statistics Symposium, University of Connecticut, June 2006
  • "Multistage evaluation of measurement error in a reliability study". Department of Applied Mathematics, Beijing University of Technology, China, July 2006
  • "Multistage evaluation of measurement error in a reliability study". Department of Statistics, George Mason University, October 2006
  • "Multistage evaluation of measurement error in a reliability study". Department of Biostatistics, Columbia University, February 2007
  • "An adaptive approach for bivariate phase II clinical trial designs". The 15th International Conference on Interdisciplinary Mathematical and Statistical Techniques, Shanghai, China, June 2007
  • "Sequential methods for evaluation of medical tests" (Invited Plenary Speech). The 15th International Conference on Interdisciplinary Mathematical and Statistical Techniques, Shanghai, China, June 2007
  • "Sample Size for a logistic regression with a covariate subject to detection limit". International Chinese Statistical Association Applied Statistics Symposium, Raleigh, NC, June 2007
  • "A two-stage procedure for selecting the best diagnostic biomarker with dichotomous outcomes". The First International Workshop in Sequential Methodologies, Auburn, Alabama, July 2007
  • "An adaptive approach for testing two correlated proportions with application to bivariate phase II clinical trial designs". Department of Biostatistics, State University of New York at Buffalo, September 2007
  • "Sequential evaluation of measurement error in a reliability study". Department of Biostatistics and Computational Biology, University of Rochester, NY, November, 2007
  • "A threshold sample-enrichment approach in a clinical trial with heterogeneous subpopulations". Division of Biostatistics, University of Maryland School of Medicine, Baltimore, MD, May 2008
  • "Sequential evaluation of measurement error in a reliability study". International Chinese Statistical Association Applied Statistics Symposium, Piscataway, NJ, June 2008
  • "Two-stage procedures in statistical experiments and analysis". Department of Mathematics and Statistics, University of South Alabama, Mobile, October 2008
  • "A threshold sample-enrichment approach in a clinical trial with heterogeneous subpopulations". Symposium in Honor of Dr. Edmund Gehan, Georgetown University Medical Center, Washington, DC, April 27, 2009
  • "Threshold sample enrichment approach with heterogeneous populations in a clinical trial for preeclampsia". University of Pennsylvania Conference on Statistical Issues in Clinical Trials: From Bench to Bedside to Community, Philadelphia, PA, April 29, 2009
  • "An efficient rank-based test for comparison of multidimensional outcomes". International Chinese Statistical Association Applied Statistics Symposium, San Francisco, CA, June 2009
  • "A threshold sample-enrichment approach in a clinical trial with heterogeneous subpopulations". International Biometric Society (ENAR) Spring Meeting, New Orleans, LA, March, 2010
  • "A rank-based test for comparison of multidimensional outcomes". Department of Biostatistics and Bioinformatics, Duke University. April 2010
  • "A min-max combination of biomarkers to improve diagnostic accuracy". First Joint Biostatistics symposium, Beijing, China, July 2010
  • "Optimality of group testing in the presence of misclassification". International Workshop on the Frontier of Statistics, Beijing, China, July 2010
  • "Using group testing to evaluate gene-environment interaction". International Chinese Statistical Association Applied Statistics Symposium, New York City, NY, June 2011
  • "Optimality of group testing in the presence of misclassification". Department of Statistics, Pennsylvania State University, September 2011
  • "A nonparametric procedure to compare clustered multiple endpoints". Department of Mathematics and Statistics, University of Maryland at Baltimore County, Baltimore, MD, October 2011
  • "Combining biomarkers to improve diagnostic accuracy". International Biometric Society (ENAR) Spring Meeting, Washington, DC, April 2012
  • "Adjusting for misclassification in stratified biomarker clinical trials". Department of Biostatistics and Bioinformatics, Duke University, May 2012
  • "Optimality of group testing in the presence of misclassification". International Chinese Statistical Association Applied Statistics Symposium, Boston, MA, June 2012
  • "From diagnostic biomarkers to innovative clinical trials-A statistician's perspective". Division of Biostatistics, UMD Marlene and Stewart Greenebaum Cancer Center, April 2013
  • "Some statistical challenges in the design and analysis of gestational diabetes studies". Joint Statistical Meetings, Montreal, Canada, August 2013
  • "A nonparametric procedure to compare clustered multiple endpoints". Department of Biostatistics-SLAM Working Group, Johns Hopkins University, September 2013
  • "Group testing in the presence of misclassification". Department of Mathematical Sciences, New Jersey Institute of Technology, November 2015
  • "On design and analysis of a stratified biomarker time-to-event clinical trial in the presence of measurement Error". International Chinese Statistical Association Applied Statistics Symposium, Fort Collins, CO, June 2015
  • "Joint model for multivariate hierarchical semicontinuous data with replication". Department of Biostatistics-SLAM Working Group, Johns Hopkins University, February 2016
  • "Estimation of diagnostic accuracy of a biomarker when the gold standard is measured with error". International Chinese Statistical Association Applied Statistics Symposium, Atlanta, GA, June 2016
  • "Inference on ratios of correlated variables with applications to dietary quality assessment". Joint Statistical Meetings, Chicago, IL, August 2016
  • "Dietary intervention studies with episodically consumed foods: From design to complex data analysis". Division of Biostatistics and Bioinformatics, Penn State College of Medicine, December 2016.
  • "Some challenges in analysis of nutritional data". Inaugural Alumni Seminar, The Rochester Data Science Society, University of Rochester, April 2017.

Contributed Presentations

  • "Uniformly minimum variance unbiased estimation of the drift of Brownian motion with parallel or triangular stopping boundaries." International Chinese Statistical Association Applied Statistics Symposium, Baltimore, MD, June 1996
  • "Uniformly minimum variance unbiased estimation of the drift of Brownian motion with parallel or triangular stopping boundaries." Joint Statistical Meetings, Chicago, IL, August 1996
  • "Unbiased estimation following sequential tests". International Biometric Society (ENAR) Spring Meeting, Memphis, TN, March 1997
  • "Two simple estimates following a sequential test". International Biometric Society (ENAR) Spring Meeting, Pittsburgh, PA, March 1998
  • "Sequential tests and estimates after overrunning". Joint Statistical Meetings, Baltimore, MD, August 1999
  • "Analysis of secondary endpoints following sequential clinical trials". International Biometric Society (ENAR) Spring Meeting, Atlanta, GA, March 1999
  • "Analysis of secondary endpoints following sequential clinical trials". International Chinese Statistical Association Applied Statistics Symposium, Washington, DC, June 1999
  • "Sample size and power determination for clustered repeated measurements". International Biometric Society (ENAR) Spring Meeting, Chicago, IL, March 2000
  • "Visualization of gene microarray data using block principal component analysis". International Biometric Society (ENAR) Spring Meeting, Charlotte, NC, March 2001
  • "Visualization of gene microarray data using block principal component analysis". National Cancer Institute SPORE Microarray Workshop on Informatics, San Francisco, CA, June 2001
  • "Nonparametric inference on the partial area under receiver operating characteristic curves". Mid-Atlantic Probability and Statistics Day, George Washington University, Washington, DC, November 2002
  • "Conditional receiver operating characteristic curves for evaluation of diagnostic accuracy in matched case-control studies". The 2nd International Biometric Society Conference of the Eastern Mediterranean Region (EMR), Antalya, Turkey, January 2003
  • "Design and analysis of comparative diagnostic accuracy studies with multiple correlated test results". International Biometric Society (ENAR) Spring Meeting, Tampa, FL, March 2003
  • "Conditional receiver operating characteristic curves for evaluation of diagnostic accuracy with clustered data". Joint Statistical Meetings, San Francisco, CA, August 2003
  • "Unbiased estimation following a group sequential test for distributions in the exponential family". Joint Statistical Meetings, Toronto, Canada, August 2004
  • "Estimating rates in a multistage phase II trial" (poster presentation). National Institutes of Health Research Festival, September 2004
  • "Supplementary analysis of probabilities at the termination of a group sequential phase II trial". International Biometric Society (ENAR) Spring Meeting, Austin, TX, March 2005
  • "Multistage evaluation of measurement error in a reliability study" (poster presentation). National Institutes of Health Research Festival, October 2005
  • "Multistage evaluation of measurement error in a reliability study". International Conference on Design and Experiments, Tianjin, China, July 2006
  • "Nonparametric procedures for comparing correlated multiple endpoints with applications to oxidative stress biomarkers". International Biometric Society (ENAR) Spring Meeting, San Antonio, TX, March 2009
  • "Two-stage procedures for selecting the best diagnostic biomarkers" (Topic Contributed). Joint Statistical Meetings, Washington, DC, August 2009
  • "A Nonparametric Procedure to Compare Clustered Multiple Endpoints". 7th International Conference on Multiple Comparison Procedures (MCP), Washington, DC, August 2011
  • "Adjusting for misclassification in stratified biomarker clinical trials". (Topic-Contributed) Joint Statistical Meeting, San Diego, CA, August 2012
  • "Nonparametric Comparison of Longitudinal Profiles of Healthy Eating Index Scores". Joint Statistical Meeting, Seattle, WA, August 2015

Collaborative Research Prior to NIH

  • University of Rochester Medical Center (September 1993-July 1997). Research Associate (June 1997-July 1998) and Consultant (August 1998-June 2000) on "Secondary inference in cardiovascular clinical trials" (NIH/R01 HL58751), NHLBI (July 1, 1997 to June 30, 2000). Principal Investigator: W. Jack Hall, Department of Biostatistics
  • St. Jude Children's Research Hospital (August 1997-March 1999)
    • Co-Investigator on "Nutrient intakes of hospitalized pediatric patients on oncology services: A comparison of patients dinning with caregivers versus patients dinning independently". Principal Investigator: Ruth Williams, Department of Clinical Nutrition
    • Co-Investigator on "Nutritional, clinical and biological effects of glutamine supplementation in children with sickle cell disease". Principal Investigator: Ruth Williams, Department of Clinical Nutrition
  • Georgetown University Lombardi Cancer Center (March 1999-Februray 2002)
    • Biostatistics Core Grant (30%) on "Cancer center support grant" (NIH/5P30 CA51008, $1,653,617), NCI (May 1, 1997-April 30, 2002). Principal Investigator: Marc Lippman
    • Co-Investigator (5%) on "Breast cancer center grant" (CC950002, $1,200,038), DOD (July 1, 1996-June 30, 2000). Principal Investigator: Marc Lippman
    • Co-Investigator (5%) on "PKC modulation in patients with advanced cancer" (NIH/R01 CA71856, $123,000), NCI (July 1, 1996-June 30, 2000). Principal Investigator: John Marshall
    • Co-Investigator (5%) on "Health promotion for women at risk for breast cancer" (NIH/R01 CA74869, $74,307), NCI (August 1, 1998-May 5, 2003). Principal Investigator: Janet Audrain
    • Co-Investigator (5% in years 1-2 and 10% in years 3-5) on "Transdisciplinary Tobacco Use Research Center (TTURC)" (NIH/1p50 CA84718-01, $2,207,020), NCI (September 30, 1999-September 29, 2004). Principal Investigator: Caryn Lerman
    • Co-Investigator (5%) on "Genetic counseling for breast cancer susceptibility in African American women", DOD (July 2000-June 2005). Principal Investigator: Chanita Hughes
    • Co-Investigator (5%) on "Anticancer therapeutic potential of VEGI, an antiangiogenic cytokine", DOD (March 2001-February 2004). Principal Investigator: Luyuan Li
    • Co-Investigator (5%) on "Polymorphic polyglutamine of A1B1 and its relationship to breast cancer", DOD (March 2001-February 2004). Principal Investigator: Lee-Jun Wong
    • Co-Investigator (5%) on "Mitochondrial DNA mutations in breast cancer", DOD (March 2001-February 2004). Principal Investigator: Lee-Jun Wong
    • Co-investigator (20% in year three) on "Mutagen sensitivity, apoptosis, and polymorphism in DNA repair as measures of prostate cancer risk", DOD (November 2001-October 2004). Principal Investigator: Radoslav Goldman

Major Collaborative Research at DIPHR, NICHD

  • Epidemiology Branch
    • Trinity Students Study (TSS), Principal Investigator: Jim Mills
    • Genetic Factors in Birth Defects, Principal Investigator: Jim Mills
    • Diabetes & Women's Health: A Study of Long-Term Health Implications of Glucose Intolerance in Pregnancy (DWH), Principal Investigator: Cuilin Zhang
    • Transgenerational Study of GDM and Obesity, Principal Investigator: Cuilin Zhang
  • Health Behavior Branch
    • Pregnancy Eating Attributes Study (PEAS), Principal Investigator: Tonja Nansel
    • Family Management of Diabetes Multisite Main Trial (FMOD), Principal Investigator: Tonja Nansel
    • Cultivating Healthy Environments in Families with Type 1 Diabetes (CHEF), Principal Investigator: Tonja Nansel

Peer-Reviewed Research Articles

  1. Liu A. On the best estimation of variance in linear models. Mathematical Statistics and Applied Probability 1988;3:232-236.
  2. Wang S, Liu A. Relative efficiency of two-stage estimators. Acta Mathematica Sinica 1989;32:42-54.
  3. Liu A, Wang S. A new relative efficiency of least squares estimates in linear models. Chinese Journal of Applied Probability and Statistics 1989;5:97-104.
  4. Liu A, Wang, S. Biased estimators for the parameters of a class of related regression system. Chinese Journal of Applied Probability and Statistics 1991;7:266-274.
  5. Liu A. An improvement of principal components estimator for seemingly unrelated regression equations. Mathematical Statistics and Applied Probability 1993;8:70-75.
  6. Liu A. An efficient estimation of seemingly unrelated multivariate regression models with application to growth curves analysis. Statistica Sinica 1993;3:421-434. [http://www.jstor.org/stable/24304967] External Web Site Policy
  7. Liu A. Selection of covariates and estimation of parameters in growth curve models. Acta Mathematica Sinica 1994;37:362-372.
  8. Liu A. Estimation of the parameters in two linear models with only some of the parameter vectors identical. Statistics and Probability Letters 1996;29(4):369-375. [DOI: 10.1016/0167-7152(95)00193-X]
  9. Liu A. On the maximum likelihood estimate for the drift of Brownian motion following a symmetric sequential probability ratio test. Communications in Statistics---Theory and Methods 1997;26(4):977-989. [DOI: 10.1080/03610929708831962]
  10. Liu A. Detecting influential covariates in a growth curve model. Computational Statistics and Data Analysis 1998;28(1):105-113. [DOI: 10.1016/S0167-9473(98)00023-1]
  11. Liu A, Hall WJ. Minimum variance unbiased estimation of the drift of Brownian motion with linear stopping boundaries. Sequential Analysis 1998;17(1):91-107. [DOI: 10.1080/07474949808836399]
  12. Liu A, Hall WJ. Unbiased estimation following a group sequential test. Biometrika 1999;86:71-78. [http://www.jstor.org/stable/2673537 External Web Site Policy DOI: https://doi.org/10.1093/biomet/86.1.71 External Web Site Policy ]
  13. Gajjar A, Fouladi M, Walter AW, Thompson SJ, Reardon DA, Merchant TE, Jenkins JJ, Liu A, Boyett JM, Kun LE, Heideman RL. Comparison of lumbar and shunt cerebrospinal fluid specimens for cytologic detection of leptomeningeal disease in pediatric patients with brain tumors. Journal of Clinical Oncology 1999;17(6):1825-1828. [DOI: 10.1200/JCO.1999.17.6.1825; PMID: 10561221]
  14. Fouladi M, Gajjar A, Boyett JM, Walter AW, Thompson SJ, Merchant TE, Jenkins JJ, Langston JW, Liu A, Kun LE, Heideman RL. Comparison of CSF cytology and spinal magnetic resonance imaging in the detection of leptomeningeal disease in pediatric medulloblastoma or primitive neuroectodermal tumor. Journal of Clinical Oncology 1999;17(10):3234-3237. [DOI: 10.1200/JCO.1999.17.10.3234; PMID: 10506624]
  15. Liu A, Boyett JM, Xiong X. Sample size calculation for planning group sequential longitudinal trials. Statistics in Medicine 2000;19(2):205-220. [PMID: 10641025]
  16. Liu A, Tan M, Boyett JM, Xiong X. Testing secondary hypotheses following sequential clinical trials. Biometrics 2000;56(2):640-644. [PMID: 10877329]
  17. Liu A. Maximum likelihood estimate following sequential probability ratio tests. Sequential Analysis 2000;19(1-2):63-75. [DOI: 10.1080/07474940008836440]
  18. Ringwald-Smith K, Hale G, Williams R, Ludwig M, Thompson A, Bowman L, Shochat S, Liu A, Barkley C. Comparison of two different low-profile gastrostomy enteral feeding devices in pediatric oncology patients. Nutrition and Clinical Practice 2000;15(4):189-192. [DOI: 10.1177/088453360001500407]
  19. Hayes AJ, Huang WQ, Yu J, Maisonpierre PC, Liu A, Kern FG, Lippman ME, McLeskey SW, Li LY. Expression and function of angiopoietin-1 in breast cancer. British Journal of Cancer 2000;83(9):1154-1160. [DOI: 10.1054/bjoc.2000.1437; PMID: 11027428]
  20. Pedrosa F, Bonilla M, Liu A, Smith K, Davis D, Ribeiro RC, Wilimas JA. Effect of malnutrition at the time of diagnosis on the survival of children treated for cancer in El Salvador and northern Brazil. Journal of Pediatric Hematology/Oncology 2000;22(6):502- 505. [PMID: 11132216]
  21. Liu A, Hall WJ. Unbiased estimation of secondary parameters following a sequential test. Biometrika 2000;88:895-900. [http://www.jstor.org/stable/2673457 External Web Site Policy DOI: https://doi.org/10.1093/biomet/88.3.895]
  22. Liu A, Shih WJ, Gehan E. Sample size and power determination for clustered repeated measurements. Statistics in Medicine 2002;21(12):1787-1801. [DOI: 10.1002/sim.1154; PMID: 12111912]
  23. Liu A. Efficient estimation of two seemingly unrelated regression equations. Journal of Multivariate Analysis 2002;82(2):445-456. [DOI: 10.1006/jmva.2001.2026]
  24. Liu A, Zhang Y, Gehan E, Clarke R. Block principal component analysis with application to gene microarray data classification. Statistics in Medicine 2002;21(22):3465-3474. [DOI: 10.1002/sim.1263; PMID: 12407684]
  25. Hall WJ, Liu A. Sequential tests and estimates after overrunning based on maximum- likelihood ordering. Biometrika 2002;89:699-70.
  26. Poola I, Abraham J, Liu A. Estrogen receptor beta splice variant mRNAs are differentially altered during breast carcinogenesis. Journal of Steroid Biochemistry and Molecular Biology 2002;82(2-3):169-179. [PMID: 12477483]
  27. Lerman C, Roth D, Kaufmann V, Audrain J, Hawk L, Liu A, Niaura R, Epstein L. Mediating mechanisms for the impact of bupropion in smoking cessation treatment. Drug and Alcohol Dependence 2002;67(2):219-223. [PMID: 12095672]
  28. Gu Z, Lee RY, Skaar TC, Bouker KB, Welch JN, Lu J, Liu A, Zhu Y, Davis N, Leonessa F, Brünner N, Wang Y, Clarke R. Association of interferon regulatory Factor-1, Nucleophosmin, nuclear Factor-kB, and cyclic AMP response element binding with acquired resistance to Faslodex (ICI 182,780). Cancer Research 2002;62(12):3428-3437. [PMID: 12067985]
  29. Ellis M, Davis N, Coop A, Liu M, Schumaker L, Lee RY, Srikanchana R, Russell CG, Singh B, Miller WR, Stearns V, Pennanen M, Tsangaris T, Gallagher A, Liu A, Zwart A, Hayes DF, Lippman ME, Wang Y, Clarke R. Development and validation of a method for using breast core needle biopsies for gene expression microarray analyses. Clinical Cancer Research 2002;8(5):1155-1166. [PMID: 12006532]
  30. Wong LJ, Wong H, Liu A. Intergenerational transmission of pathogenic heteroplasmic mitochondrial DNA. Genetics in Medicine 2002;4(2):78-83. [DOI: 10.109700125817- 200203000-00005; PMID: 11882784]
  31. Liu A. A simple low-bias estimate following a sequential test with linear boundaries. In: Crossing Boundaries: Statistical Essays in Honor of Jack Hall, IMS Monograph Series, Kolassa J and Oakes D, Editors, 2003; p 47-58. [http://www.jstor.org/stable/4356262] External Web Site Policy
  32. Mazumdar M, Liu A. Group sequential design for comparative diagnostic accuracy studies. Statistics in Medicine 2003;22(5):727-739. [DOI: 10.1002/sim.1386; PMID: 12587102]
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  125. Boghossian NS, Sicko RJ, Kay DM, Rigler SL, Caggana M, Tsai MY, Yeung EH, Pankratz N, Cole BR, Druschel CM, Romitti PA, Browne ML, Fan R, Liu A, Brody LC, Mills JM. Rare copy number variants implicated in posterior urethral valves. American Journal of Medical Genetics 2016;170(3):622-633. [DOI: 10.1002/ajmg.a.37493; PMID: 26663319]
  126. Zhu Y, Olsen SF, Mendola P, Yeung EH, Vaag A, Bowers K, Liu A, Bao W, Li S, Madsen C, Grunnet LG, Granström C, Hansen S, Martin K, Chavarro JE, Hu FB, Langhoff- Roos J, Damm P, Zhang C. Growth and obesity through the first 7 y of life with levels of maternal glycemia during pregnancy: a prospective cohort study. The American Journal of Clinical Nutrition 2016;103(3):794-800. [DOI: 10.3945/ajcn.115.121780; PMID: 26817507; PMCID: PMC4763496].
  127. Li S, Zhu Y, Chavarro JE, Bao W, Tobias DK, Ley SH, Forman JP, Liu A, Mills J, Bowers K, Strøm M, Hansen S, Hu FB, Zhang C. Healthful dietary patterns and the risk of hypertension among women with a history of gestational diabetes mellitus: a prospective cohort study. Hypertension 2016;67(6):1157-1165. [DOI: 10.1161/HYPERTENSIONAHA.115.06747; PMID: 27091899; PMCID: PMC4865422]
  128. Cai X, Li H, Liu A. A marginal rank-based inverse normal transformation approach to comparing multiple clinical trial endpoints. Statistics in Medicine 2016;35(19):3259-3271. [DOI: 10.1002/sim.6928; PMID: 26990442; PMCID: PMC4938741]
  129. Wu M, Shu Y, Li Z, Liu A. Repeated significance tests of linear combinations of sensitivity and specificity of a diagnostic biomarker. Statistics in Medicine 2016;35(19):3397-3412. [DOI: 10.1002/sim.6932; PMID: 26947768; PMCID: PMC4938793].
  130. Nansel TR, Lipsky LM, Liu A. Greater diet quality is associated with more optimal glycemic control in a longitudinal study of youth with type 1 diabetes. The American Journal of Clinical Nutrition 2016;104(1):81-87. [DOI: 10.3945/ajcn.115.126136; PMID: 27194309; PMCID: PMC4919526]
  131. Kang L, Liu A, Tian L. Linear combination methods to improve diagnostic/prognostic accuracy on future observations. Statistical Methods in Medical Research 2016;25(4):1359– 1380. [DOI: 10.1177/0962280213481053; PMID: 23592714; PMCID: PMC4180010]
  132. Lipsky LM, Gee B, Liu A, Nansel TR. Glycemic control and variability in association with body mass index and body composition over 18 months in youth with type 1 diabetes. Diabetes Research and Clinical Research 2016;120:97-103. [DOI: 10.1016/j.diabres.2016.07.028; PMID: 27525365]
  133. Nansel TR, Leah ML, Siega-Riz AM, Burger K, Faith M, Liu A. Pregnancy Eating Attributes Study (PEAS): a cohort study examining behavioral and environmental influences on diet and weight change in pregnancy and postpartum. BMC Nutrition 2016;2(1):45.
  134. Lipsky LM, Gee B, Liu A, Nansel TR. Body mass index and adiposity indicators associated with cardiovascular biomarkers in youth with type 1 diabetes followed prospectively. Pediatric Obesity 2016 Jul 15. [DOI: 10.1111/ijpo.12167; PMID: 27417272]
  135. Sun X, Liu A, Li Z. Maximizing an ROC-type measure via linear combinations of biomarkers. Health Services and Outcomes Research Methodology 2016;16(3):103-116. [DOI: 10.1007/s10742-016-0150-z]
  136. Nansel TR, Lipsky LM, Eisenberg MH, Liu A, Mehta SN, Laffel LM. Can families eat better without spending more? Improving diet quality does not increase diet cost in a randomized clinical trial among youth with type 1 diabetes and their parents. Journal of the Academy of Nutrition and Dietetics 2016;116(11):1751-1759.e1. [DOI: 10.1016/j.jand.2016.07.005 External Web Site Policy ; PMID: 27597745; PMCID: PMC5085870]
  137. Eisenberg MH, Lipsky LM, Dempster KW, Liu A, Nansel TR. I should but I can't: Controlled motivation and self-efficacy are related to disordered eating behaviors in adolescents with type 1 diabetes. Journal of Adolescent Health 2016;59(5):537-542. [DOI: 10.1016/j.jadohealth.2016.06.008; PMID: 27567063; PMCID: PMC5077655]
  138. Wu M, Zhang D, Liu A. Estimation of a diagnostic accuracy index of a diagnostic biomarker when the reference gold standard is continuous and measured with error. Journal of Biopharmaceutical Statistics 2016;26(6):1111-1117. [DOI: 10.1080/10543406.2016.1226330 External Web Site Policy ; PMID: 27548574]
  139. Foster JC, Liu D, Albert PS, Liu A. Identifying subgroups of enhanced predictive accuracy from longitudinal biomarker data using tree-based approaches: applications to fetal growth. Journal of the Royal Statistical Society: Series A 2017;180(1):247-261. [DOI: 10.1111/rssa.12182; PMID: 28239239; PMCID: PMC5321661]
  140. Li Q, Liu A, Xiong W. D-optimality of group testing for joint estimation of correlated rare diseases with misclassification. Statistica Sinica. 2017;27(2):823-838.
  141. Gee BT, Nansel TR, Liu A. Reduction of hypoglycaemic events with a behavioural intervention: A randomized clinical trial for paediatric patients with Type I diabetes mellitus. Diabetic Medicine 2017;34(3):340-347. [DOI: 10.1111/dme.12744; PMID: 25763988; PMCID: PMC4589424]
  142. Chiu CY, Jung J, Chen W, Weeks DE, Ren H, Boehnke M, Amos CI, Liu A, Mills JM, Ting-Lee ML, Xiong M, Fan R. Meta-analysis of quantitative pleiotropic traits for next-generation sequencing with multivariate functional linear models. European Journal of Human Genetics 2017;25(3):350-359. [DOI: 10.1038/ejhg.2016.170; PMID: 28000696; PMCID: PMC5315507]
  143. Bagh MB, Peng S, Chandra G, Zhang Z, Singh SP, Pattabiraman N, Liu A, Mukherjee AB. Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model. Nature Communications 2017;8:14612. [DOI: 10.1038/ncomms14612; PMID: 28266544; PMCID: PMC5344305]
  144. Mendola P, Ghassabian A, Mills JL, Zhang C, Tsai MY, Liu A, Yeung EH. Retinol- binding protein 4 and lipids prospectively measured during early to mid-pregnancy in relation to preeclampsia and preterm birth risk. American Journal of Hypertension 2017; 30:569-576. [DOI: 10.1093/ajh/hpx020; PMID: 28338737; DOI: 10.1093/ajh/hpx020 External Web Site Policy ]
  145. Carter T, Sicko R, Kay D, Browne M, Romitti, P, Edmunds Z, Liu A, Fan R, Druschel C, Caggana M, Brody L, Mills J. Copy-number variants and candidate gene mutations in isolated split hand/foot malformation. Journal of Human Genetics 2017; [DOI: 10.1038/jhg.2017.56; PMID:28539665]
  146. Zhang W, Liu Y, Tang L, Liu A, Mills JL, Sun Y. Li Q. GATE: an efficient procedure in study of pleiotropic genetic associations. BMC Genomics. 2017.
  147. Eisenberg MH, Lipsky LM, Gee B, Liu A, Nansel TR. Parent healthful eating attitudes and motivation are prospectively associated with dietary quality among youth with type 1 diabetes. Vulnerable Children and Youth Studies: An International Interdisciplinary Journal for Research, Policy and Care 2017
  148. Wang Y, Sun H, Wang H, Liu A. Efficiency of targeted clinical trials with pre-post designs for a binary endpoint. Statistics in Biosciences. (In press).
  149. Yin L, Diao G, Liu A. A Semiparametric method for comparing the discriminatory ability of biomarkers subject to limit of detection. Statistics in Medicine. (In press).
  150. Yimer WK, Albert PF, Lipsky LM, Nansel, TR, Liu A. A joint model for multivariate hierarchical semicontinuous data with replications. Statistical Methods in Medical Research. (Revision invited).

Books and Book Chapters

  1. Liu A, Schisterman EF. Principal component analysis. In Encyclopedia of Biopharmaceutical Statistics, 2nd ed. 2004.
  2. Liu A, Yu KF. Inference following a sequential clinical trial. In Clinical Trials Handbook, Wiley, 2009.
  3. Liu A, Liu CL, Yu KF. Group-Sequential methods in biomedical research. In Methods and Applications of Statistics in the Life and Health Sciences. Wiley, 2009.
  4. Liu A, Liu CL, Yu KF. Group-Sequential methods in biomedical research. In Encyclopedia of Statistical Sciences. Wiley, 2010.
  5. Zou KH, Liu A, Bandos A, Ohno-Machado L, Rockette H. Statistical Evaluation of Diagnostic Performance: Topics in ROC Analysis. Chapman & Hall/CRC, New York, 2011.
  6. Chen Z, Liu A, Qu Y, Tang L, Ting N, Tsong Y (editors). Applied Statistics in Biomedicine and Clinical Trials Design: Selected Papers from 2013 ICSA/ISBS Joint Statistical Meetings. Springer, New York, 2015.

Non-Research Articles

  1. Bai RK, Leal SM, Covarrubias D, Wong LJC, Liu A. In response. Cancer Research. 2008;68(2):624. DOI: 10.1158/0008-5472.CAN-07-5706.
  2. Mietlowski W, Kolassa JE, Geneus V, Liu A, Shen W, Yu CR, Zou KH. Effective Research-oriented internships to foster the next generation of statisticians. AmStat News December 2016;22-24.
  3. Liu A, Yue LQ. A conversation with Dr. Greg Campbell. Journal of Biopharmaceutical Statistics 2016;26(6):1007-1019. DOI :10.1080/10543406.2016.1226331External Web Site Policy
  4. Nansel T, Liu A, Gee B. Response to 'Early view: an opportunity for enhanced peer review'.
  5. Diabetic Medicine 2017 Mar 22. [DOI: 10.1111/dme.13353; PMID: 28326603]
  6. Liu A. Get prepared to become a successful statistician in a collaborative research environment. https://www.urmc.rochester.edu/education/graduate/ur-best-blog/april-2017-1/get-prepared-to-become-a-successful-statistician-i.aspxExternal Web Site Policy