The first symptom of Rett syndrome is usually the loss of muscle tone, called hypotonia (pronounced hahy-poh-TOH-nee-uh).1 With hypotonia, an infant's arms and legs will appear "floppy."2
Although hypotonia and other symptoms of Rett syndrome often present themselves in stages, some typical symptoms can occur at any stage. Symptoms may vary among patients and range from mild to severe.3
Symptoms can vary from person to person and from one stage to the next. Symptoms may also improve in the “Plateau Phase” (see What are the types and phases?).
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