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The Human Placenta Project: Placental Structure and Function in Real Time

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May 27–28, 2014

Sponsor/Co-Sponsor(s)

NICHD

Agenda


May 27, 2014

7:30 a.m. Goals for Human Placenta Project (HPP) and Workshop
Alan Guttmacher and Cathy Spong
   
7:40 a.m. Introductions
Alan Guttmacher and Cathy Spong
   
8:00 a.m. Overview of Placental Formation and Structure
Graham Burton
   
8:45 a.m. Maternal Placental Syndromes: Conditions Due to Placental Abnormalities
George Saade
   
9:30 a.m. Current Methods for Assessing Placental Development and Function and Their Limitations
Yoel Sadovsky
   
10:15 a.m. Break
   
10:30 a.m. Panel Discussion: Shared Pathophysiological Processes That May Be Assessed Using Knowledge and Technologies From Other Fields
(6-Minute Presentations on the Specific Dysfunction and Its Relevance, Followed by Discussion)
  • Anatomy and Tissue Structure: Susan Fisher
  • Utero-Placental Perfusion: Kathleen Schmainda
  • Tissue and Cellular Metabolism: Nick Illsley
  • Immunology, Inflammation: Gil Mor
   
11:15 a.m. Lunch
   
12:00 p.m. Breakout Sessions: Shared Pathophysiological Processes that may be Assessed Using Knowledge and Technologies from Other Fields
  • Breakout 1: Anatomy and Tissue Structure: Led by Susan Fisher
  • Breakout 2: Utero-Placental Perfusion: Led by Kathleen Schmainda
  • Breakout 3: Tissue and Cellular Metabolism (e.g., Nutrient Transfer, Biochemistry, -omics): Led by Nick Illsley
  • Breakout 4: Immunology, Inflammation (e.g., Graft vs. Host Interactions): Led by Gil Mor
Charge to Breakout Sessions:
  • What functions are important to evaluate in real time?
  • What are the current state-of-the-art approaches in obstetrics for assessing these processes?
  • How are these processes assessed in other fields?
  • What technologies might be applicable to HPP?
  • What technologies need to be developed to address the pathophysiologic process?
   
2:00 p.m. Breakout Groups Report Back, Followed by Discussion
   
3:30 p.m. Panel Presentation: Applying Technologies To Study the Placenta in Real Time: Currently Utilized Imaging Technologies—How To Optimize or Further Their Use
(6-Minute Presentations, Followed by Discussion)
  • Ultrasound, Dopple: Alfred Abuhamad
  • MRI, fMRI, MR angiography: John Sled
   
4:00-6:00 p.m. Breakout Sessions: Currently Utilized Imaging Technologies—How To Optimize or Further Their Use
  • Breakout 1: Ultrasound: Led by Alfred Abuhamad
  • Breakout 2: MRI: Led by John Sled
Charge to Breakout Groups:
  • What are the “adjacent possible” to application in obstetrics for each technology?
  • What technologies might be applicable to HPP?
  • What technologies need to be developed to address the pathophysiologic process?
  • Describe what needs to be done to develop/stimulate/
    encourage/facilitate this area to move forward to understand human placental structure and function in real time.
  • Are there initial steps that must first occur (e.g., technologies to develop)?
   
6:00 p.m. Adjourn



May 28, 2014

8:00 a.m. Breakout Groups Report Back: Currently Utilized Imaging Technologies—How To Optimize or Further Their Use
   
9:00 a.m. Panel Presentation: Emerging or Potentially Promising Technologies—How To Develop and/or Optimize Their Use
(6-Minute Presentations on the Technology, Followed by Discussion)
  • Nanotechnology: Erik Rytting
  • Biochemical Techniques: Carolyn Ott
  • High-Throughput –omics: Diana Bianchi
  • Systems Science, Computational Biology: Brian Cox
  • Data Management: Peter Basser
   
10:15 a.m. Breakout Sessions: Emerging or Potentially Promising Technologies—How To Develop and/or Optimize Their Use
  • Breakout 1: Nanotechnology (e.g., Nanorobots, Intravascular Sensors): Led by Erik Rytting
  • Breakout 2: Biochemical Techniques: Led by Carolyn Ott
  • Breakout 3: High-Throughput –omics: Led by Diana Bianchi
  • Breakout 4: Systems Science, Computational Biology: Led by Brian Cox
  • Breakout 5: Data Management (e.g., Sharing, Manipulation, Reconstruction): Led by Peter Basser
Charge to Breakout Groups:
  • What are the “adjacent possible” to application in obstetrics for each technology?
  • What technologies might be applicable to HPP?
  • What technologies need to be developed to address the pathophysiologic process?
  • Describe what needs to be done to develop/stimulate/ encourage/facilitate this area to move forward to understand human placental structure and function in real time.
  • Are there initial steps that must first occur (e.g., technologies to develop)?
   
12:30 p.m. Lunch
   
1:30 p.m. Breakout Groups Report Back, Identifying More Specific
Targets for HPP Phase I
   
3:15 p.m. Design and Develop the HPP “Roadmap”
Alan Guttmacher and Cathy Spong
   
4:15 p.m. Wrap Up and Next Steps
Alan Guttmacher
   
4:30 p.m. Adjourn


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Last Updated Date: 06/04/2014
Last Reviewed Date: 06/04/2014
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