PHACS is funded by the NICHD Maternal and Pediatric Infectious Disease Branch (formerly the Pediatric, Adolescent, and Maternal AIDS Branch); the National Heart, Lung, and Blood Institute; the National Institute of Alcohol Abuse and Alcoholism; the National Institute of Allergy and Infectious Diseases; the National Institute on Deafness and Other Communication Disorders; the National Institute of Dental and Craniofacial Research; the National Institute on Drug Abuse; the National Institute of Mental Health; the National Institute of Neurological Disorders and Stroke; and the NIH Office of AIDS Research.
The PHACS Network is funded through Cooperative Agreement (U01) and currently comprises 32 clinical sites at 21 institutions, a Data and Operations Center (DOC), and a Coordinating Center (CC). The DOC provides operations, design, methodological, and analytic expertise to PHACS research protocols, while the CC provides support and guidance to the PHACS Scientific Leadership Group, which helps to guide the network's scientific directions and ensure its scientific integrity. Additional oversight and coordination are provided by an executive committee and a steering committee. To maximize efficiency, the PHACS Network has data-sharing agreements with other studies and cross-enrolls participants with non-PHACS protocols.
The overall goals of this Network are to:
PHACS currently conducts three major studies (described below):
Both SMARTT and AMP also include sub-studies focused on infant bone health, memory and attention, nutrition during pregnancy, mitochondrial research, neuroimaging, epigenetics, oral health, and pulmonary function.
PHACS conducts three major studies:
AMP UP, which continues the goals of AMP in youth 18 years of age and older by emphasizing mobile technologies for some of the follow up.
These studies examine the following and other effects and risk factors related to HIV infection, antiretroviral use, and antiretroviral exposure in developing children and youth:
The Harvard School of Public Health serves as the PHACS DOC and the PHACS CC is at Tulane University.