The IMPAACT Network is a cooperative group of institutions, investigators, and other collaborators focused on evaluating potential therapies for HIV infection and its related symptoms in infants, children, adolescents, and pregnant women, including clinical trials of HIV/AIDS interventions for and prevention of mother-to-child transmission.
The IMPAACT Network resulted from the merger of two predecessor networks: the Pediatric AIDS Clinical Trials Group and the perinatal scientific working group of the HIV Prevention Trials Network. It is co-funded by the NICHD Maternaland Pediatric Infectious Disease Branch (MPIDB) (formerly the Pediatric, Adolescent, and Maternal AIDS Branch) and the National Institute of Allergy and Infectious Diseases, and receives funding from other NIH Institutes and Offices, including the National Institute of Mental Health.
As an international project, the IMPAACT Network includes both a domestic research agenda and an international research agenda. The domestic research agenda includes a focus on evaluating the pharmacokinetics, safety, optimal dosing, and long-term complications of new antiretroviral (ARV) therapies for HIV/AIDS in pediatric and adolescent populations, among other topics and activities. The international research agenda includes a focus on the prevention of mother-to-child transmission of HIV and reduction of maternal and infant morbidity and mortality from HIV/AIDS through studies such as Promoting Maternal and Infant Survival Everywhere (PROMISE).
The IMPAACT Network collaborates with the NICHD Domestic and International Pediatric/Maternal HIV Clinical Studies Network, the Adolescent Medicine Trials Network for HIV/AIDS Interventions, and with other NICHD-, NIH-, and organization-led HIV/AIDS research networks and projects.
As of 2010, the Network included:
- 39 domestic and 34 international Clinical Research Sites (CRSs), where clinical trials are conducted
- Statistical and Data Management Center (SDMC) to manage and coordinate data
- IMPAACT Community Advisory Board (ICAB), which enables communities to provide input and feedback on Network activities
The IMPAACT Network conducts clinical trials of HIV/AIDS therapy and prevention in maternal, pediatric, and adolescent patients. Current Network studies include (but are not limited to) the following:
- A randomized trial (PROMISE) comparing various antenatal and postnatal strategies of preventing mother-to-child transmission of HIV in different geographical areas and resource settings
- A clinical trial to determine whether women with CD4 counts above 400 per mm3 should continue or discontinue highly active ARV therapy after pregnancy
- A study of the pharmacokinetics and safety of ARV drugs in pregnant HIV-infected women
- Several pharmacokinetic studies to evaluate interactions between ARV drugs and anti-malarial medications, anti-tuberculosis medications, and psychiatric medications
- Several studies evaluating the safety and efficacy of different vaccines in HIV-infected children, including rotavirus, meningococcal, parainfluenza, human papillomavirus, and anti-tuberculosis vaccines
- Studies to evaluate the pharmacokinetics and safety of drugs to treat complications of HIV or its treatment, including atorvastatin to treat hyperlipidemia associated with ARV drugs and alendronate to treat low bone mineral density in infected children
- Studies of new ARV drugs, such as raltegravir, etravirine, and the new integrase inhibitor GSK1349527, in infants, children, and adolescents
- Studies to evaluate the pharmacokinetics of ARV drugs in HIV-infected children with special conditions such as malnutrition or prematurity
- Strategies for the treatment of infected children with multi-class drug failure
Visit the IMPAACT Network Web site for more details.