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Appendix B

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Table 8. Adult Test Scores for PKUCS Subjects Grouped by Usual Adult Phe Level (Values tabulated are mean ± s.d.)

* Change from 12-year WISC-R or WRAT score

** p-values are for illustration only, due to small sample sizes

- WAIS-R - - WRAT 3 -
n Verbal Perform Full n Reading Spelling Arithmetic
Usual Adult Phe Level < 15.9 mg/dl
   Parent IQ 11     117±8        
   Adult Score 11 106±11 111±13 109±12 10 108±5 107±6 103±6
   Change* 11 +5 +6 +6 8 0 +5 +16
   p** 0.28 0.08 0.12 0.96 0.23 0.0009
Usual Adult Phe Level 16.0 - 19.9 mg/dl
   Parent IQ 17 104±8
   Adult Score 17 94±11 99±14 96±13 14 98±9 100±9 95±13
   Change* 14 +1 +3 +2 11 +2 +3 +10
   p** 0.57 0.21 0.39 0.37 0.26 0.01
Usual Adult Phe Level 20.0 - 23.9 mg/dl
   Parent IQ 10 110±11
   Adult Score 11 95±16 94±16 94±16 10 96±12 99±16 92±11
   Change* 9 +4 +2 +3 8 -4 +4 +11
   p** 0.13 0.64 0.28 0.25 0.38 0.001
Usual Adult Phe Level 24.0 - 27.9 mg/dl
   Parent IQ 12 103±14
   Adult Score 13 88±13 92±12 88±12 11 88±21 87±21 89±24
   Change* 11 -3 -6 -6 8 -4 +2 +12
   p** 0.19 0.09 0.07 0.17 0.48 0.005
Usual Adult Phe Level => 28.0 mg/dl
   Parent IQ 12 106±11
   Adult Score 12 90±11 94±17 90±14 12 97±17 94±16 88±15
   Change* 8 -2 -2 -3 9 0 -1 +6
   p** 0.35 0.58 0.22 0.90 0.76 0.11

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Last Updated Date: 08/29/2006
Last Reviewed Date: 08/29/2006
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology