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Down Syndrome: Clinical Trials

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The NICHD conducts and supports a variety of clinical research related to Down syndrome. Select a link below to learn more about these projects.

Featured NICHD Clinical Trials 

  • Multicenter Vitamin E Trial in Aging Persons with Down Syndrome
    The goal of this study is to determine the safety and efficacy of the administration of vitamin E in slowing the rate of cognitive/functional decline in older persons with Down syndrome. Vitamin E is being used in this study because it has been shown to delay the progression of Alzheimer disease. Researchers want to examine if it can also help people with Down syndrome.
  • Down Syndrome Metabolic Health Study
    The purpose of this study is to determine which measures best capture cardiovascular disease risk and type 2 diabetes risk in children and adolescents with Down syndrome. The researchers hypothesize that Down syndrome is associated with worse cardiometabolic risk factors for a given body mass index compared with controls.
  • Treatment Trial of Subclinical Hypothyroidism in Down Syndrome
    The purpose of this study is to learn about the effects of treating subclinical hypothyroidism with thyroid hormone replacement in children and adolescents with Down syndrome. The researchers hypothesize that treatment with thyroid hormone replacement will improve cardiometabolic health and quality of life.

NICHD Clinical Trials

ClinicalTrials.gov Search Results

Information on current NIH-sponsored clinical trials on Down syndrome is available by following the link below or by calling 800-411-1222.

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Last Updated Date: 04/09/2014
Last Reviewed Date: 01/17/2014
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology