The Longitudinal Investigation of Fertility and the Environment (LIFE) Study is designed to examine the relation between ubiquitous environmental chemicals, lifestyle, and human fecundity and fertility. The primary exposures of interest include persistent chemicals (e.g., PCBs, PBDEs and PFOS) and lifestyle factors (e.g., stress, cigarette smoking, caffeine, and alcohol usage). The LIFE Study comprised 501 couples recruited prior to conception who were followed daily while attempting to become pregnant for up to 12 months of trying. Pregnant women were followed monthly until delivery. The primary study outcomes include couple fecundability as measured by time-to-pregnancy, pregnancy loss, and infertility. Pregnancy outcomes include length of gestation, birth size and the secondary sex ratio. Data analysis is currently underway. Several cases of environmental chemicals have been associated with fecundity impairments, such as longer time required to become pregnant and poor semen quality.
Germaine Louis, Ph.D., M.S.
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