Pharmacology is the study of drugs and their effects. Pharmacokinetics (PK) is the study of drug absorption, distribution, metabolism, and elimination, while pharmacodynamics (PD) is the study of how drugs produce their effects on the body. Multiple gaps in knowledge regarding the use of therapeutics in children and pregnant women have resulted in inadequate labeling and in frequent off-label use of prescription drugs in those two populations. The NICHD and, in particular, OPPTB, supports research on various medications in children and pregnant women, primarily to help ensure their safety and usefulness for preventing, treating, and managing various diseases and disorders.
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