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The MPIDB supports and conducts a wide range of domestic and international research related to the epidemiology, diagnosis, clinical manifestations, pathogenesis, transmission, treatment, and prevention of HIV infection and its associated infectious (such as tuberculosis [TB], malaria, and hepatitis), as well as non-infectious complications in pregnant and non-pregnant women, infants, children, adolescents, and the family unit as a whole. As the HIV epidemic has evolved in the United States and globally, the MPIDB has ensured that research funded by the Branch reflects these changes and addresses important research opportunities and gaps as they arise. The research gaps in children and pregnant women related to many HIV-associated co-infections, such as TB, hepatitis, and malaria, have become evident as HIV research has become increasingly global in nature. The MPIDB has responded accordingly by promoting and funding new research related to these infectious pathogens, as well as investigation of vaccines to prevent HIV-related or other high-priority infectious diseases in children, adolescents, and pregnant women.
The Branch collaborates with other NICHD Branches, NIH Institutes, other federal agencies such as the Centers for Disease Control and Prevention (CDC), the President’s Emergency Plan for AIDS Relief (PEPFAR), and interested private organizations that share a focus on maternal, pediatric, and adolescent HIV infection and related infectious diseases. The goals of the Branch’s activities include the elimination of new pediatric HIV infections in the United States and globally and optimizing the health of HIV-infected children, adolescents, and women so that they can lead meaningful and productive lives free of the complications of HIV and its treatment.
- Branch-funded research findings:
- Article: Siberry GK, Williams PL, Mendez H, et al; for the Pediatric HIVAIDS Cohort Study (PHACS). Safety of tenofovir use during pregnancy: early growth outcomes in HIV-exposed uninfected infants. AIDS. 2012 Jun 1;26(9):1151-1159. PMID:22382151
- Issues Related to Adolescent HIV Prevention Research:
- Kapogiannis BG, Handelsman E, Ruiz MS, Lee S. Introduction: Paving the way for biomedical HIV prevention interventions in youth. J Acquir Immune Defic Syndr. 2010 Jul;54 Suppl 1:S1-4. PMID:20571417
- Rudy BJ, Kapogiannis BG, Lally MA, Gray GE, Bekker LG, Krogstad P, McGowan I. Youth-specific considerations in the development of preexposure prophylaxis, microbicide, and vaccine research trials. J Acquir Immune Defic Syndr. 2010 Jul;54 Suppl 1:S31-42. PMID:20571421
- Selected research from MPID-supported studies:
- Pediatric HIV/AIDS Cohort Study: Williams PL, Seage GR 3rd, Van Dyke RB, et al for the Pediatric HIV/AIDS Cohort Study. (2012). A Trigger-based Design for Evaluating the Safety of In Utero Antiretroviral Exposure in Uninfected Children of Human Immunodeficiency Virus-Infected Mothers. Am J Epidemiol. May 1;175(9):950-961. PMID:22491086
- International Maternal Pediatric Adolecents AIDS Clinical Trials Network/NICHD International and Domestic Maternal and Pediatric HIV Trials Network: Nielsen-Saines K, Komarow L, Cu-Uvin S, for the ACTG 5190/PACTG 1054 Study Team. (2012). Infant Outcomes After Maternal Antiretroviral Exposure in Resource-Limited Settings. Pediatrics. May 14. [Epub ahead of print] PMID:22585772
- Adolescent Trials Network: Agwu AL, Bethel J, Hightow-Weidman LB, et al for the ATN 061 Team and the Adolescent Medicine Trials Network for HIV/AIDS Interventions. (2012). Substantial multiclass transmitted drug resistance and drug-relevant polymorphisms among treatment-Naïve behaviorally HIV-infected youth. AIDS Patient Care STDS. Apr;26(4):193-6. PMID:22563607
- Women’s Interagency HIV Study: Linas BS, Minkoff H, Cohen MH et al. (2011). Relative time to pregnancy among HIV-infected and uninfected women in the Women's Interagency HIV Study, 2002-2009. AIDS. Mar 13;25(5):707-11 PMID:21297418
- Microbicide Trials Network: Beigi R, Noguchi L, Parsons T et al. (2011). Pharmacokinetics and placental transfer of single-dose tenofovir 1% vaginal gel in term pregnancy. J Infect Dis. Nov 15;204(10):1527-31. PMID:21930612
- Current HIV Treatment Guidelines for children, adolescents, women and prevention of mother-to-child HIV transmission
- Federally approved guidelines and information about the current treatment regimens and prevention strategies for HIV infection and HIV-related illnesses for adults, adolescents, children, and infants and prevention of mother-to-child HIV transmission: http://aidsinfo.nih.gov/guidelines