Publications

2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993 | 1992 | 1991 | 1990 | 1989 | 1988 | 1987 | 1986 | 1985 | 1984 | 1983 | 1982 | 1981 | 1980 | 1979 | 1978 | 1977 | 1976 | 1975 | 1974 | 1973 | 1972 | 1971 | 1970 | 1969 | 1968 | 1967

2020

2019

2018

2017

  • Backlund PS, Urbanski HF, Doll MA, Hein DW, Bozinoski M, Mason CE, Coon SL, Klein DC. (2017) Daily Rhythm in Plasma N-acetyltryptamine. J Biol Rhythms. 32(3):195-211.. doi: 10.1177/0748730417700458. Epub 2017 May 3. PMID: 28466676

2016

2015

2014

2013

2012

2011

2010

2009

2008

2007

2006

2005

2004

2003

2002

2001

2000

1999

1998

1997

1996

1995

1994

1993

1992

  • Babila, T. and Klein, D.C. (1992) Stimulus deprivation increases pineal Gs-alpha and G-beta. Journal of Neurochemistry 59:1356-1362.
  • Babila, T., Schaad, N., and Klein, D.C. (1992) Development of MEKA, cytosolic G-beta and Santigen in the rat pineal gland and retina. Brain Research 585: 141-148.
  • Babila, T, Schaad, N., and Klein, D.C. (1992) Rat pineal Gsaalpha, Gibeta and Goa: relative abundance and development. Brain Research 572:232-235.
  • Donohue, S.J., Roseboom, P.H., and Klein, D.C. (1992) Bovine hydroxyindole-O-methyltransferase: Significant sequence revision. Journal of Biological Chemistry 267:5184-5185.
  • Huang, S.K., Klein, D.C., and Korf, H. (1992) Immunocytochemical demonstration of rod-opsin, S-antigen,and neuron-specific proteins in the human pineal gland. Cell and Tissue Research 267:493-498.
  • Klein, D.C., Roseboom, P.H., Donohue, S.J., and Marrs, B.L. (1992) Evolution of melatonin as a night signal: Contribution from a primitive photosynthetic organism. Molecular and Cellular Neuroscience 3:181-183.
  • Klein, D.C., Schaad, N., Namboodiri, M.A.A., Yu, L., and Weller, J.L. (1992) Regulation of pineal serotonin N-acetyltransferase activity. Biochemical Society Transactions 20:299-304.
  • Klein, D.C., Schaad, N.C., Yu, L., Babila, T and Ceña, V. (1992) The mammalian melatonin rhythm generating system: Role of calcium and cyclic AMP in the control of serotonin N-acetyltransferase activity. In: Discussions in Neuroscience, M. Zatz (ed) Elsevier vol VIII pp 54-56.
  • Korf, H.W., White, B.H., Schaad, N.C., and Klein, D.C. (1992) Recoverin in pineal organs and retinae of various vertebrate species including man. Brain Research 595:57-66.
  • Schaad, N.C. and Klein, D.C. (1992) Characterization of a2-beta-adrenergic receptors of rat pinealocytes. Endocrinology 130:2804-2810.
  • Vanecek, J. and Klein, D.C. (1992) Melatonin inhibits GnRH stimulation of [Ca++]i in neonatal rat pituitary cells. Endocrinology 130:701-707.
  • Vanecek, J. and Klein, D.C. (1992) Sodium-dependent effects of melatonin on membrane potential of neonatal rat pituitary cells. Endocrinology 131:939-946.
  • Weller, J.L. and Klein, D.C. (1992) The pineal adrenergic cyclic GMP response develops two weeks after the adrenergic-cyclic AMP response development. Developmental Brain Research 68:144-147.

1991

  • Ceña, V., Halperin, J., Yeandle, S. and Klein, D.C. (1991) Norepinephrine stimulates potassium efflux from pinealocytes: Evidence for involvement of biochemical "AND" gate operated by calcium and adenosine 3', 5'-monophosphate. Endocrinology 128:559-569.
  • Klein, D.C., Moore, R.Y. and Reppert, S.M,eds. (1991) Suprachiasmatic Nucleus: The Mind's Clock. Oxford University Press, NY.
  • Schaad, N., Shinohara, T. Abe, T. and Klein, D.C. (1991) Photoneural control of the synthesis and phosphorylation of pineal MEKA (phosducin). Endocrinology 129: 3289-3298.

1990

1989

1988

  • Chik, C., Ho, A. and Klein, D.C. (1988) a1-alpha-Adrenergic potentiation of vasoactive intestinal peptide stimulation of rat pinealocyte adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate: Evidence for a role of calcium and protein kinase-C. Endocrinology 122: 702-708.
  • Chik, C., Ho., A. and Klein, D.C. (1988) Dual receptor regulation of cyclic nucleotides: a1-alpha-adrenergic potentiation of vasoactive intestinal peptide stimulation of pinealocyte adenosine 3',5'-monophosphate. Endocrinology 122: 1646-1651.
  • Ho., A., Chik, C.L. and Klein, D.C. (1988) Effects of protein kinase inhibitor (1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H7) on protein kinase C activity and adrenergic stimulation of cAMP and cGMP in rat pinealocytes. Biochemical Pharmacology 37: 1015-1020.
  • Ho, A.K., Chik, C.L. and Klein, D.C. (1988) Permissive role of calcium in a1-alpha-adrenergic stimulation of pineal phosphatidylinositol phosphodiesterase (Phospholipase C) Activity. Journal of Pineal Research 5: 553-564.
  • Ho, A.K., Thomas, T.P., Chik, C.L., Anderson, W. and Klein, D.C. (1988) Protein kinase C: Subcellular redistribution by increased Ca2+ influx. Journal of Biological Chemistry 263: 9292-9297.
  • Klein, D.C. (1988) Citation Classic: Commentary on Klein, D.C. and Weller J.L. Indole metabolism in the pineal gland: A circadian rhythm in N-acetyltransferase. Science 169: 1093-1095 (1970) Current Contents 31: 16.
  • Klein, D.C. (1988) Citation Classic: Commentary on Klein, D.C. and Raisz L.G. Prostaglandins: Stimulation of bone resorption in tissue culture. Endocrinology: 86:1436-1440 (1970) Current Contents 30: 17.
  • Klein, D.C., Ho, A.K. Chik, C.L. and Weller, J.L. (1988) Adrenergic regulation of pineal cAMP and cGMP: Evidence for a gating mechanism. Catecholamines VI. Part A Dahlstrom (ed) Alan R. Liss, Inc. 71: 415-422.
  • Klein, D.C., Weller, J.L., Sugden, A.L., Sugden, D., Vanecek, J., Chik, C.L. and Ho, A.K. (1988) Integration of multiple receptor mechanisms regulating pineal cyclic nucleotides. Fundamentals and Clinics in Pineal Research, Trentini, G.P., DeGaetani, C., and Pevet, P. (eds) Raven Press, New York, pp 111-119.
  • Reig, J.A. and Klein, D.C. (1988) Submicogram quantities of unstained proteins are visualized on polyvinylidene difluoride membranes by transillumination. Journal of Applied and Theoretical Electrophoresis 1: 59-60.
  • Sugden, D., Ho, A.K., Sugden, A.L. and Klein, D.C. (1988) Negative feedback mechanisms: evidence that desensitization of pineal a1-beta-adrenergic responses involves protein kinase C. Endocrinology 123: 1425-1432.
  • Sugden, D. and Klein, D.C. (1988) Adrenergic regulation of pinealocyte cyclic GMP. Catecholamine Research, Part A Dahlstrom (ed) Alan R. Liss, Inc. 72: 423-428.
  • Sugden, D. and Klein, D.C. (1988) Activators of protein kinase C act at a post-receptor site to amplify cAMP production in rat pinealocytes. Journal of Neurochemistry 32: 149-155.

1987

  • Ceña, V., Gonzalez-Garcia, C., Svoboda, P. and Klein, D.C. (1987) Developmental study of ouabain inhibition of adrenergic induction of rat pineal serotonin N-acetyltransferase (EC 2.3.1.87). Journal of Biological Chemistry 262: 14467-14471.
  • Chik, C., Ho, A. and Klein, D.C. (1987) Transmembrane receptor cross-talk: concurrent VIP and a1-alpha-adrenergic activation rapidly elevates pinealocyte cGMP > 100-fold. Biochem. Biophys. Res. Comm. 146: 1478-1484.
  • Chik, C., Ho., A. and Klein, D.C. (1987) Ethanol inhibits dual receptor stimulation of pineal cAMP and cGMP by vasoactive intestinal peptide and phenylephrine. Biochem. Biophys. Res. Commun. 147: 145-151.
  • Gonzales, C., Ceña, V. and Klein, D.C. (1987) Characterization of the a+alpha-like Na+, K+-ATPase which mediates ouabain inhibition of adrenergic induction of N-acetyltransferase (E.C.2.3.1.87) activity: studies with isolated pinealocytes. Molecular Pharmacology 32: 792-797.
  • Ho, A.K., Ceña, V. and Klein, D.C. (1987) Cardiac glycosides stimulate phospholipase C activity in rat pinealocytes. Biochemical and Biophysical Research Communications 142: 819-825.
  • Ho, A., Chik, C. and Klein, D.C. (1987) Protein kinase C is involved in adrenergic stimulation of pineal cGMP accumulation. Journal of Biological Chemistry 262: 10059-10064.
  • Ho, A.K. and Klein, D.C. (1987) Activation of a1-alpha-adrenoreceptors, protein kinase C, or treatment with intracellular free Ca2+ elevating agents increases pineal phospholipase A2 activity. Journal of Biological Chemistry 262: 11764-11770.
  • Ho, A.K. and Klein, D.C. (1987) Phosphatidylinositol phosphodiesterase (Phospholipase C) activity in the pineal gland: characterization and photoneural regulation. Journal of Neurochemistry 48: 1033-1038.
  • Klein, D.C., Vanecek, J., Ho, A.K., Sugden, A.L. and Sugden, D. (1987) a1-alpha and 1 -beta-adrenergic regulation of pineal cyclic AMP and cyclic GMP. In: Magistretti, P.J., Morrison, J.H., Reisine, T.D., Axelrod, J. and Bloom, F. (eds) Discussions in Neurosciences III: Transduction of Neuronal Signals (pp 151-160).
  • Namboodiri, M.A.A., Brownstein, M.J., Voisin, P., Weller, J.L. and Klein, D.C. (1987) A simple and rapid method for the purification of ovine pineal arylalkylamine N-acetyltransferase. Journal of Neurochemistry 48: 580-585.
  • Namboodiri, M.A.A., Brownstein, M., Weller, J.L., Voisin, P. and Klein, D.C. (1987) Multiple forms of arylamine N-acetyltransferase in the rat pineal gland: Purification of one molecular form. Journal of Pineal Research 4: 235-246.
  • Sugden, D. and Klein, D.C. (1987) A cholera toxin substrate regulates cyclic GMP content of rat pinealocytes. Journal of Biological Chemistry 262: 7447-7450.
  • Sugden, D. and Klein, D.C. (1987) Inactivation of rat pineal hydroxyindole-O-methyltransferase by disulfide-containing compounds. Journal of Biological Chemistry 262: 6489-6493.
  • Sugden, A.L., Sugden, D. and Klein, D.C. (1987) a1-alpha-adrenoceptor activation elevates cytosolic calcium in rat pinealocytes by increasing net influx. Journal of Biological Chemistry 262: 741-745.
  • Yanovski, J., Witcher, J., Adler, N., Markey, S. and Klein, D.C. (1987) Stimulation of the paraventricular nucleus area of the hypothalamus elevates urinary 6-hydroxymelatonin during daytime. Brain Research Bulletin 19: 129-133.

1986

  • Basile, A., Klein, D.C. and Skolnick, P. (1986) Characterization of benzodiazepine receptors in the bovine pineal gland: evidence for the presence of an atypical binding site. Molecular Brain Research 1: 127-135.
  • Ho, T., Somers, R. and Klein, D.C. (1986) Development and regulation of rhodopsin kinase in rat pineal and retina. Journal of Neurochem. 46: 1176-1179.
  • Klein, D.C., Sugden, D., Vanecek, J., Thomas, T. and Anderson, W. (1986) Phospholipid-protein kinase C involvement in the adrenergic regulation of pinealocyte cyclic AMP: A model of how modulations act? In L.A. Horrocks, I. Freysz and G. Toffano. Fidia Research Series 4 Phospholipids in the Nervous system: Molecular and pharmacological aspects. Liviana Press, Padova pp 113-120.
  • Korf, H., Klein, D.C., Zigler, S., Gery, I. and Schachenmayer, W. (1986) S-Antigen-like immunoreactivity in a human pineocytoma. Acta. Neuropathologica 69: 165-167.
  • Korf, H., Oksche, A., Ekstrom, P., Gery, I., Zigler, J.S. and Klein, D.C. (1986) Pinealocyte projections into the mammalian brain revealed with S-antigen antiserum. Science 231: 735-737.
  • Korf, H.W., Oksche, A., Ekström, P., van Veen, T., Zieler, J.S., Gery, I., Stein, P. and Klein, D.C. (1986) S-Antigen immunocytochemistry. In: Pineal and Retinal Relationships. O'Brien, P.J. and Klein, D.C. (eds) Academic Press, Orlando, pp 343-355.
  • Namboodiri, M.A.A., Dubbels, R. and Klein, D.C. (1986) Arylalkylamine N-acetyltransferase from mammalian pineal gland. Methods in Enzymology 142: 583-590.
  • Namboodiri, M.A.A. and Klein, D.C. (1986) Multiple aromatic amine N-acetyltransferases in the pineal gland. In Pineal and Retinal Relationships (eds. P.J. O'Brien and D.C. Klein) Academic Press, Orlando, pp 133-150.
  • Santer, D., Heydorn, W., Creed, J., Klein, D.C. and Jacobowitz, D. (1986) Subfornical organ: Effects on individual proteins. Brain Research Bulletin 372: 107-114.
  • Shinohara, T., Craft, C.M., Stein, P., Ziegler Jr., J.S., Wistow, G., Katial, A., Gery, I. and Klein, D.C. (1986) Isolation of cDNAs for bovine S-antigen. In: Pineal and Retinal Relationships. P.J. O'Brien and D.C. Klein (eds.) Academic Press, Orlando pp 331-343.
  • Sugden, D., Ceña, V. and Klein, D.C. (1986) Hydroxyindole-O-methyltransferase. Methods in Enzymology 142: 590-596.
  • Sugden, D. and Klein, D.C. (1986) Adrenergic regulation of pineal cyclic AMP and cyclic GMP in rat pinealocytes. In Pineal and Retinal Relationships (eds. P.J. O'Brien and D.C. Klein) Academic Press, Orlando pp 293-305.
  • Sugden, A.L., Sugden, D. and Klein, D.C. (1986) Essential role of calcium influx in the adrenergic regulation of cAMP and cGMP in rat pinealocytes. Journal of Biological Chemistry 261: 11608-11612.
  • Sugden, D., Voisin, P. and Klein, D.C. (1986) Purification of rat HIOMT. Journal of Pineal Research 3: 389-395.
  • van Veen, T., Elofsson, R., Hartwig, H.G., Gery, I., Mochizuki, M. and Klein, D.C. (1986) Retinal S-antigen: Immunocytochemical and immunochemical studies on distribution in animal photoreceptors and pineal organs. Experimental Biology 45: 15-25.
  • van Veen T., Ostholm, T., Giershick, P., Spiegel, A., Somers, R., Korf, H.W. and Klein, D.C. (1986) alpha-Transducin immunoreactivity in retinae and sensory pineal organs of adult vertebrates. Proc. Natl. Acad. Sci. U.S.A. 83: 912-916.
  • Vanecek, J., Sugden, D., Weller, J. and Klein, D.C. (1986) See-saw signal processing in pinealocytes involves reciprocal changes in the 1-alpha-adrenergic component of the cyclic GMP response and the beta adrenergic component of the cyclic AMP responses. Journal of Neurochemistry 47: 678-686.

1985

1984

  • Gold, M., Heydorn, W., Creed, G.J., Weller, J.L., Klein, D.C. and Jacobowitz, D.M. (1984) In Vitro [35S]methionine labeled protein in microdissected discrete brain areas: Marked regional differences revealed by two-dimensional gel electrophoresis. Electrophoresis 5: 116-121.
  • Klein, D.C. (1984) Melatonin and puberty. Science 224: 6.
  • Klein, D.C., Sugden, D., Voisin, P., Vanecek, J. (1984) The mammalian melatonin rhythm generating system in Endocrinology, Proceedings of the VIII International Congress, F. Labrie, and L. Prouix (Eds.) Elsevier Science Publishers B.V., Amsterdam, pp. 135-138.
  • Matthew, E., Parfitt, A.G., Sugden, D., Engelhardt, D.L., Zimmerman, E.A. and Klein, D.C. (1984) Benzodiazepines: Rat pinealocyte binding sites and augmentation of norepinephrine-stimulation of N-acetyltransferase activity. J. Pharm. and Exp. Ther. 228: 434-438.
  • Reppert, S., Perlow, M., Artman, H., Ungerleider, L., Fisher, D., Mishkin, M. and Klein, D.C. (1984) The circadian rhythm of oxytoxin in primate cerebrospinal fluid: Effects of destruction of the suprachiasmatic nuclei. Brain Research 307: 384-387.
  • Rollag, M., Welsh, M.G. and Klein, D.C. (1984) Effect of acute light exposure upon melatonin content, NAT activity, and nuclear volume in the gerbil pineal complex. Pineal Research 1: 339-347.
  • Somers, R.L. and Klein, D.C. (1984) Rhodopsin kinase activity in the mammalian pineal gland and other tissues. Science 226: 182-184.
  • Sugden, D. and Klein, D.C. (1984) Regulation of rat pineal 1-alpha-adrenoceptors. Journal of Neurochemistry 44: 63-67.
  • Sugden, D. and Klein, D.C. (1984) Rat pineal alpha1-adrenoceptors: Identification and characterization using [125I]-iodo-2-[betaβ-(4-hydroxyphenyl)-ethylaminomethyl]tetralone ([125I]HEAT). Endocrinology 114: 435-440.
  • Sugden, D., Weller, J.L., Klein, D.C., Kirk, K.L. and Creveling, C.R. (1984) Alpha-adrenergic potentiation of beta-adrenergic stimulation of rat pineal N-acetyltransferase: Studies using cirazoline and fluorine analogs of norepinephrine. Biochem. Pharm. 33: 3947-3950.
  • Voisin, P., Namboodiri, M.A.A. and Klein, D.C. (1984) Arylamine N-acetyltransferase and arylalkylamine N-acetyltransferase in the mammalian pineal gland. Journal of Biological Chemistry 259: 10913-10918.
  • Weissman, B.A., Skolnick, P. and Klein, D.C. (1984) Regulation of "Peripheral-type" binding sites for benzodiazepines in the pineal gland. Biochemistry and Behavior 21: 821-824.

1983

  • Kapatos, G., Kaufman, S., Weller, J.L. and Klein D.C. (1983) The development of tetrahydrobiopterin and guanosine-5'-triphosphate cyclohydrolase: differential patterns in rat brain and pineal gland. Brain Research 258: 351-355.
  • Klein, D.C. (1983) Converging circadian rhythms could explain effects of the pineal gland: Implications for psychiatric disease in Circadian Rhythms in Psychiatry. Wehr, T.A. and Goodwin, F.K. (Eds.) The Boxwood Press, pp. 221-233.
  • Klein, D.C., Smoot, R., Weller, J.L., Higa, S., Markey, S.P., Creed, G.J. and Jacobowitz, D.M. (1983) Lesions of the paraventricular nucleus area of the hypothalamus disrupt the suprachiasmatic spinal cord circuit in the melatonin rhythm generating system. Brain Research Bulletin 10: 647-652.
  • Klein, D.C., Sugden, D. and Weller, J.L. (1983) Postsynaptic alpha-adrenergic receptors potentiate the beta-adrenergic stimulation of pineal serotonin N-acetyltransferase. Proc. Natl. Acad. Sci. 80: 599-603.
  • Klein, D.C., Wheler, G.H.T. and Weller, J.L. (1983) Taurine in the pineal gland in Sulfur Amino Acids: Biochemical and Clinical Aspects. Kuriyama, K., Huxtable, R.J. and Iwata, H. (Eds.) Alan R. Liss, Inc., New York, NY, pp. 169-181.
  • Mefford, I.N., Chang, P., Klein, D.C., Namboodiri, M.A.A., Sugden, D. and Barchas, J. (1983) Reciprocal day/night relationship between serotonin oxidation and N-acetylation products in the rat pineal gland. Endocrinology 113: 1582-1586.
  • Namboodiri, M.A.A., Sugden, D., Klein, D.C. and Mefford, I. (1983) 5-Hydroxytryptophan elevates serum melatonin. Science 221: 659-661.
  • Namboodiri, M.A.A., Sugden, D., Mefford, I.N. and Klein, D.C. (1983) Melatonin and related compounds. In "Methods in Biogenic Amine Research" (eds. Parvez, H., Parvez, S. and Nagatsu, T.) Elsevier/North Holland Biomedical Press, Amsterdam, Netherlands, pp. 549-565.
  • Sugden, D. and Klein, D.C. (1983) beta-Adrenergic receptor control of rat pineal hydroxyindole-O-methyltransferase. Endocrinology 113: 348-353.
  • Sugden, D. and Klein, D.C. (1983) Regulation of rat pineal hydroxyindole-O-methyltransferase in neonatal and adult rats. J. Neurochem. 40: 1647-1653.
  • Sugden, D. and Klein, D.C. (1983) Adrenergic stimulation of rat pineal hydroxyindole-O-methyltransferase. Brain Research 265: 348-351.
  • Sugden, D., Namboodiri, M.A.A., Weller, J.L. and Klein, D.C. (1983) Melatonin synthesizing enzymes: Serotonin N-acetyltransferase and hydroxyindole-O-methyltransferase. In "Methods in Biogenic Amine Research" (eds. Parvez, H., Parvez, S. and Nagatsu, T.) Elsevier/North Holland Biomedical Press, Amsterdam, Netherlands, pp. 567-572.

1982

  • Kapatos, G., Kaufman, S., Weller, J.L., and Klein, D.C. (1982) Development and regulation of biopterin in the pineal gland of the rat in Melatonin Rhythm Generating System: Developmental Aspects. Klein, D.C. (Ed.) Karger, Basel, pp. 108-123.
  • Kapatos, G., Kaufman, S., Weller, J.L. and Klein, D.C. (1982) Adrenergic-cyclic AMP regulation of biopterin biosynthesis in the pineal gland in Monoamine Enzymes. Weiner, N., Usdin, E. and Youdim, M. (Eds.) MacMillan Publishers Ltd., London, England, pp. 231-240.
  • Klein, D.C. (1982) (ed.) The Melatonin Rhythm Generating System: Developmental Aspects. Kargar Press, Basal.
  • Klein, D.C. and Namboodiri, M.A.A. (1982) Inactivation of pineal N-acetyltransferase by disulfide exchange: A possible role of S-S peptides in Monoamine Enzymes. Weiner, N., Usdin, E. and Youdim, M. (Eds.) MacMillan Publishers Ltd., London, England, pp. 711-772.
  • Klein, D.C. and Namboodiri, M.A.A. (1982) Control of the circadian rhythm in pineal serotonin N-acetyltransferase activity: possible role of protein thiol:disulfide exchange. Trends in Biochemical Science 7: 98-102.
  • Namboodiri, M.A., Favilla, J. and Klein, D.C. (1982) Activation of pineal acetyl coenzyme A hydrolase by disulfide peptides. J. Biol. Chem. 257: 10030-10032.
  • Namboodiri, M.A.A. and Klein, D.C. (1982) Purification of sheep pineal N-acetyltransferase in Monoamine Enzymes. Weiner, N., Usdin, E. and Youdim, M. (Eds.) MacMillan Publishers Ltd., London, England, pp. 701-710.

1981

1980

  • Klein, D.C., Weller, J.L., Auerbach, D. and Namboodiri, M.A.A. (1980) Regulation of pineal N-acetyltransferase: Focus on "turn-off". In: Enzymes and Neurotransmitters in Mental Disease. Usdin, E., Sourkes, T.L. and Youdim, M.B. (Eds.), pp. 603-627.
  • Martin, J.E., Kirk, K.L. and Klein, D.C. (1980) Effects of 6-Hydroxy-, 6-fluoro-, and 4,6-difluoromelatonin on the in vitro pituitary response to luteinizing hormone-releasing hormone. Endocrinology 106: 398-401.
  • Namboodiri, M.A.A., Weller, J.L. and Klein, D.C. (1980) Rapid and reversible activation of acetyl CoA hydrolase in intact pineal cells by disulfide exchange. Biochemical and Biophysical Research Communications 96: 188-195.
  • Namboodiri, M.A.A., Weller, J.L. and Klein, D.C. (1980) Evidence of inactivation of pineal indoleamine N-acetyltransferase by protein thiol-disulfide exchange. J. Biol. Chem. 255: 6032-6035.
  • Perlow, M.J., Reppert, S.M., Tamarkin, L., Wyatt, R. and Klein, D.C. (1980) Photic regulation of melatonin: Man and monkey are not the same. Brain Research 182: 211-216.
  • Reppert, S.M. and Klein, D.C. (1980) Mammalian pineal gland: Basic and clinical aspects. In: Endocrine Function of the Brain. Motta, M. (Ed.) Raven Press, New York, pp. 327-371.
  • Reppert, S.M., Perlow, M. and Klein, D.C. (1980) Cerebrospinal fluid melatonin. In: Neurobiology of CSF. Wood, J.H. (Ed.) Plenum Publishers, pp. 579-589.
  • Tamarkin, L., Reppert, S.M., Klein, D.C., Pratt, B. and Goldman, B.P. (1980) Studies on the daily pattern of pineal melatonin in the Syrian hamster. Endocrinology 107: 1525-1529.
  • Tamarkin, L., Reppert, S.M., Orloff, D.J., Klein, D.C., Yellon, S.M. and Goldman, B.D. (1980) Ontogeny of the pineal melatonin rhythm in the Syrian (Mesacricetus auratus) and Siberian (Phodopus sungorus) hamsters and in the rat. Endocrinology 107: 1061-1064.
  • Wheler, G.H.T. and Klein, D.C. (1980) Taurine release from the pineal gland is stimulated by a beta-adrenergic mechanism. Brain Research 187: 155-164.

1979

1978

  • Buda, M. and Klein, D.C. (1978) A suspension culture of pinealocytes: Regulation of N-acetyltransferase activity. Endocrinology 103: 1483-1493.
  • Buda, M. and Klein, D.C. (1978) Function and regulation of pineal N-acetyltransferase. In: Biochemistry and function of amine enzymes. Usdin, E., Weiner, N. and Youdim, M. (Eds.) M. Dekker, New York, pp. 545-555.
  • Buda, M. and Klein, D.C. (1978) N-acetylation of biogenic amines. In: Biochemistry and function of amine enzymes. Usdin, E., Weiner, N. and Youdim, M. (Eds.) M. Dekker, New York, pp. 527-544.
  • Klein, D.C. (1978) The pineal gland: A model of neuroendocrine regulation. In: The Hypothalamus. Reichlin, S., Baldessarini, R.J. and Martin, B. (Eds.) Raven Press, New York, pp. 303-327.
  • Klein, D.C., Buda, M., Kapoor, C. and Krishna, G. (1978) Pineal serotonin N-acetyltransferase activity: Abrupt decrease in adenosine 3', 5'-monophosphate may be signal for "turnoff". Science 199: 309-311.
  • Klein, D.C. and Martin, J. (1978) Direct effects of pineal indoles on the pituitary response to luteinizing hormone-releasing hormone. In: Sexual Endocrinology. Vokaer, R. and DeMabeuge, R. (Eds.) Masson Publishing Inc., New York, 12: 175-184.
  • Reppert, S. and Klein, D.C. (1978) Transport of maternal [3H]melatonin to suckling rats and the fate of [3H]melatonin in the neonatal rat. Endocrinology 102: 582-588.

1977

1976

  • Binkley, S., Klein, D.C. and Weller, J.L. (1976) Pineal serotonin N-acetyltransferase activity: Protection of stimulated activity by acetyl-CoA and related compounds. Journal of Neurochemistry. 26: 51-55.
  • Chen, C.H., Klein, D.C. and Robinson, J.C. (1976) Monoamine oxidase in rat placenta, human placenta, and cultured choriocarcinoma. Journal of Reproduction and Fertility 46: 477-479.
  • Chiou, C.Y., Trzeciakowski, J. and Klein, D.C. (1976) Histamine mediation of nicotine effects on postganglionic sympathetic junctions. Neuropharmacology 15: 689-693.
  • Klein, D.C. (1976) Pineal function: Control of circadian rhythms. In: Excerpta Medica International Congress Series No 402. Endocrinology Proceedings of the V International Congress of Endocrinology, Hamburg, July 18-24, 1976, Volume I James, V.H.T. (Ed) pp. 72-76.
  • Klein, D.C. and Kirk, K.L. (1976) 2-Fluoro-L-Histidine: A histidine analog which inhibits enzyme induction. Symposium on Biochemistry Involving Carbon-Fluorine Bonds. Washington, D.C., ACS Symposium Series No. 28, pp. 35-56.
  • Klein, D.C., Kirk, K.L., Weller, J.L., Oka, T., Parfitt, A. and Owens, I. (1976) 2-Fluoro-L-Histidine, an inhibitor of enzyme induction. Molecular Pharmacology 12: 720-730.
  • Klein, D.C. and Parfitt, A. external link (1976) A protective role of nerve endings in the stress-stimulated increase in pineal N-acetyltransferase activity. In: Catecholamines and Stress. Kvetnansky, R. and Usdin, E. (Eds.) Pergamon Press, New York, pp. 119-128.
  • Martin, J.E. and Klein, D.C. (1976) Melatonin inhibition of the neonatal pituitary response to luteinizing hormone-releasing factor. Science 191: 301-302.
  • Martin, J.E. and Klein, D.C. (1976) Long-term organ culture of rat anterior pituitary glands. Endocrinology 99: 1189-1198.
  • Mata, M.M., Schrier, B.K., Klein, D.C., Weller, J.L. and Chiou, C.Y. (1976) On GABA function and physiology in the pineal gland. Brain Research 118: 383-394.
  • Parfitt, A.G. and Klein, D.C. (1976) Sympathetic nerve endings in the pineal gland protect against acute stress-induced increase in N-acetyltransferase (E.C. 2.3.1.5) activity. Endocrinology 99: 840-851.
  • Parfitt, A., Weller, J.L. and Klein, D.C. (1976) Beta adrenergic blockers decrease adrenergically stimulated N-acetyltransferase activity in pineal glands in organ culture. Neuropharmacology 15: 353-358.

1975

  • Binkley, S.A., MacBride, S., Klein, D.C. and Ralph, C.L. (1975) Regulation of pineal rhythms in chickens: Refractory period and nonvisual light perception. Endocrinology 96: 848-853.
  • Klein, D.C. and Parfitt, A. (1975) Ouabain blocks the adrenergic cyclic AMP stimulation of pineal N-acetyltransferase activity. In: Cyclic Nucleotides in Disease. Weiss, B. (Ed.) University Park Press, Baltimore, Maryland, pp 257-265.
  • Klein, D.C., Weller, J.L., Parfitt, A. and Kirk, K.L. (1975) 2-Fluoro-L-Histidine: An incorporated inhibitor of the adrenergic stimulation of pineal N-acetyltransferase activity. In: Catecholamine Research. Vol. II. Almgren, O., Carlsson, A. and Engel, J. (Eds.) North-Holland, New York, pp. 293-300.
  • Parfitt, A., Weller, J.L., Klein, D.C., Sakai, K.K. and Marks, B.H. (1975) Blockade by ouabain or elevated potassium ion concentration of the adrenergic and adenosine cyclic 3',5'-monophosphate-induced stimulation of pineal serotonin N-acetyltransferase activity. Molecular Pharmacology 11: 241-255.
  • Ralph, C., Binkley, S.A., MacBride, S. and Klein, D.C. (1975) Regulation of pineal rhythms in chickens: Effects of blinding, constant light, constant dark, and superior cervical ganglionectomy. Endocrinology 97: 1373-1378.

1974

  • Bensinger, R.E., Klein, D.C., Weller, J.L. and Lovenberg, W.M. (1974) Radiometric assay of total trytophan hydroxylation by intact cultured pineal glands. Journal of Neurochemistry. 23: 111-117.
  • Chen, C., Klein, D.C. and Robinson, J.C. (1974) Catechol-O-methyltransferase in rat placenta, human placenta and choriocarcinoma grown in culture. Journal of Reproduction and Fertility 39: 407-410.
  • Klein, D.C. (1974) Circadian rhythms in indole metabolism in the rat pineal gland. In: The Neurosciences; Third Study Program. Schmitt, F.O. and Worden, F.G. (Eds.) MIT Press, Cambridge, Massachusetts, pp. 509-515.
  • Klein, D.C. and Yuwiler, A. (1974) Beta-adrenergic regulation of indole metabolism in the pineal gland. In: Frontiers in Catecholamines. Pergamon Press, New York, pp. 321-325.
  • Moore, R.Y. and Klein, D.C. (1974) Visual pathways and the central neural control of a circadian rhythm in pineal serotonin N-acetyltransferase activity. Brain Research 71: 17-33.
  • Schrier, B. and Klein, D.C. (1974) Absence of choline acetyltransferase in rat and rabbit pineal gland. Brain Research 79: 347-351.
  • Ulrich, R., Yuwiler, A., Wetterberg, L. and Klein, D.C. (1974) Effects of light and temperature on the pineal gland in suckling rats. Neuroendocrinology 13: 255-263.
  • Vaughan, M.L., Vaughan, G.M. and Klein, D.C. (1974) Arginine Vasotocin: Effects on the development of reproductive organs. Science 168: 938-939.

1973

  • Binkley, S., Klein, D.C. and Weller, J.L. (1973) Dark induced increase in pineal serotonin N-acetyltransferase activity: A refractory period. Experientia 29: 1339-1340.
  • Binkley, S.A., MacBride, S., Klein, D.C. and Ralph, C.L. (1973) Pineal enzymes: Regulation of avian melatonin synthesis. Science 181: 273-275.
  • Coyle, J.T., Jacobowitz, D., Klein, D.C. and Axelrod, J. (1973) Dopaminergic neurons in explants of substantia nigra in culture. Neurobiology 4: 461-470.
  • Klein, D.C. (1973) The role of serotonin N-acetyltransferase in the adrenergic regulation of indole metabolism in the pineal gland. In: Serotonin and Behavior. Barchas, J. and Usdin, E. (Eds.) Academic Press, New York, pp. 109-119.
  • Klein, D.C. and Weller, J.L. (1973) Adrenergic-adenosine 3',5'-monophosphate regulation of serotonin N-acetyltransferase activity and the temporal relationship of serotonin N-acetyltransferase activity to synthesis of 3H-N-acetylserotonin and 3H-melatonin in the cultured rat pineal gland. J. Pharmacol. Exp. Ther. 186: 516-527.
  • Klein, D.C., Yuwiler, A., Weller, J.L. and Plotkin, S. (1973) Postsynaptic adrenergic-cyclic AMP control of the serotonin content of cultured rat pineal glands. Journal of Neurochemistry 21: 1261-1271.

1972

1971

  • Berg, G.R. and Klein, D.C. (1971) Non-cartesian pineal function. New England Journal of Medicine 284: 332.
  • Berg, G.R. and Klein, D.C. (1971) Pineal gland in organ culture. II. Role of adenosine 3',5'-monophosphate in the regulation of radiolabelled melatonin production. Endocrinology 89: 453-464.
  • Klein, D.C. and Raisz, L.G. (1971) Role of adenosine-3',5'-monophosphate in the hormonal regulation of bone resorption: Studies with cultured fetal bone. Endocrinology 89: 818-826.
  • Klein, D.C., Reiter, R.J. and Weller, J.L. (1971) Pineal N-acetyltransferase activity in blinded and anosmic male rats. Endocrinology 89: 1020-1023.
  • Klein, D.C., Weller, J.L. and Moore, R.Y. (1971) Melatonin metabolism: Neural regulation of pineal serotonin:acetyl coenzyme A N-acetyltransferase activity. Proceedings of the National Academy of Sciences, U.S.A. 68: 3107-3110.
  • Reiter, R.J. and Klein, D.C. (1971) Observations on the pineal glands, the Harderian glands, the retina, and the reproductive organs of adult female rats exposed to continuous light. Journal of Endocrinology 51: 117-125.

1970

  • Klein, D.C. and Berg, G.R. (1970) Pineal gland: Stimulation of melatonin production by norepinephrine involves cyclic AMP mediated stimulation of N-acetyltransferase. Advances in Biochemical Psychopharmacology 3: 241-263.
  • Klein, D.C., Berg, G.R., Weller, J.L. and Glinsmann, W. (1970) Pineal gland: Dibutyryl cyclic adenosine monophosphate stimulation of labelled melatonin production. Science 167: 1738-1740.
  • Klein, D.C., Berg, G.R. and Weller, J.L. (1970) Melatonin synthesis: Adenosine 3',5'-monophosphate and norepinephrine stimulate N-acetyltransferase. Science 168: 979-980.
  • Klein, D.C. and Raisz, L.G. (1970) Prostaglandins: Stimulation of bone resorption in tissue culture. Endocrinology 86: 1436-1440.
  • Klein, D.C. and Rowe, J. (1970) Pineal gland in organ culture. I. Inhibition by harmine of serotonin-14C oxidation, accompanied by stimulation of melatonin-14C production. Molecular Pharmacology 6: 164-171.
  • Klein, D.C. and Weller, J.L. (1970) Input and output signals in a model neural system: The regulation of melatonin production in the pineal gland. In Vitro 6:197-240.
  • Klein, D.C. and Weller, J.L. (1970) Indole metabolism in the pineal gland: A circadian rhythm in N-acetyltransferase. Science 169: 1093-1095.
  • Raisz, L.G., Klein, D.C. Trummel, C.T. and Brand, J.S. (1970) Hormonal factors influencing bone resorption in tissue culture. In: Hormone Regulation, Hamburgh, M. and Barrington, E.J.W. (Eds.). Appleton Century-Crofts, New York, pp. 679-686.
  • Rowe, J.W., Reichert, J.R., Klein, D.C. and Reichlin, S. (1970) Relation of the pineal gland and environmental lighting to thyroid function in the rat. Neuroendocrinology 6: 247-254.

1969

  • Klein, D.C. and Lines, S.V. (1969) Pineal hydroxyindole-O-methyltransferase activity in the growing rat. Endocrinology 84: 1523-1525.
  • Klein, D.C. and Notides, A. (1969) Thin-layer chromatographic separation of pineal gland derivatives of serotonin-14C. Analytical Biochemistry 31: 480-483.
  • Reiter, R.J., Klein, D.C. and Donofrio, R.J. (1969) Preliminary observations on the reproductive effects of the pineal gland in blinded, anosmic male rats. Journal of Reproduction and Fertility 19: 563-565.

1968

  • Klein, D.C. and Talmage, R.V. (1968) Thyrocalcitonin suppression of hydroxyproline release from bone. Proceedings of the Society for Experimental Biology and Medicine 127: 95-99.
  • Klein, D.C. and Talmage, R.V. (1968) Evidence of the secretion of thyrocalcitonin at normal and subnormal plasma calcium levels. Endocrinology 82: 132-136.
  • Raisz, L.G., Brand, J.S., Klein, D.C. and Au, W.Y.W. (1968) Hormonal factors influencing bone resorption. In: Progress in Endocrinology, Excerpta Medica International Congress Series No. 184, 696-703.

1967

  • Klein, D.C., Morii, H., and Talmage, R.V. (1967) Effect of thyrocalcitonin, administered during peritoneal lavage, on removal of bone salts and their radioisotopes. Proceedings of the 50th Annual Meeting of the Federation of American Societies for Experimental Biology (30) 124: 627-633.
  • Talmage, R.V. and Klein, D.C. (1967) Relation of endogenous thyrocalcitonin secretion to plasma calcium levels. Calcitonin: Proceedings of the Symposium on Thyrocalcitonin and the C Cells. pp. 260-267, William Heinemann Medical Books Ltd., London.
  • Klein, D.C. (1967) The mode of action of thyrocalcitonin. Thesis, Rice University.
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