Publications

  • Zhao P, Kavarthapu R, Anbazhagan R, Liao M, Dufau ML. Interaction of Positive Coactivator 4 with Histone 3.3 Protein is Essential for Transcriptional Activation of the Luteinizing Hormone Receptor Gene. BBA-Gene Regul Mech 2018; 1861:971-981.
  • Dufau ML, Tsai Morris CH. Gonadotropine-Regulated Testicular RNA helicase (GRTH/DDX25): An Essential Regulator of Spermatogenesis. Trends Endocrinol Metab 2007; 18:314-320.
  • Dufau ML, Kavarthapu, R.  Gonadotropin Regulated Testicular RNA Helicase, Two Decades of Studies in its Structure function and Regulation from its Discovery Opens a Window for Development of a Non-Hormonal Male Contraceptive. Frontiers in Endocrinology 2019; 10:576-586.
  • Tsai-Morris CH, Koh E, Sheng Y, Maeda Y, Gutti R, Namiki M, Dufau ML. Polymorphism of the GRTH/DDX25 Gene in Normal and Infertile Japanese men: a Missense Mutation Associated with Loss of GRTH Phosphorylation.  Mol Hum Reprod 2007; 13: 887-892.    
  • Kavarthapu R, Anbazhagan R, Raju M, Morris CT, Pickel J, Dufau ML , Targeted Knock-In Mice with a Human Mutation in GRTH/DDX25 Reveals the Essential Role of Phosphorylated GRTH in Spermatid Development during Spermatogenesis. Hum Mol Genet 2019;28: 2561-2572.
  • Raju M, Hassan SA, Kavarthapu R, Anbazhagan R, Dufau ML Characterization of the Phosphorylation Site of GRTH/DDX25 and Protein Kinase A Binding Interface Provide Structural Basis for the Design of a Non-Hormonal Male Contraceptive. Sci Rep 2019; 9:42857-42867.
  • Kavarthapu R, Anbazhagn R, Sharma AK, Shiloach J, Dufau ML.  Linking Phospho-Gonadotropin Regulated Testicular RNA Helicase (GRTH/DDX25) to Histone Ubiquitination and Acetylation Essential for Spermatid Development During Spermiogenesis.  Front Cell Dev Biol 2020; 8:310 
  • Anbazhagan R, Kavarthapu, R, Coon SL, Dufau ML. Role of Phosphorylated Gonadotropin-Regulated Testicular RNA Helicase (GRTH/DDX25) in the Regulation of Germ Cell Specific mRNAs in Chromatoid Bodies During Spermatogenesis. Front Cell Dev Biol 2020; 8:58001.    
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