Contents
Dedication, xi
Preface, xv
Cellular DNA Replication
- Dupliation of DNA in Eukaryotic Cells, 1
Thomas J. Kelly and Bruce Stillman - Eukaryotic DNA Replication Origins, 31
Mirit I. Aladjem, Arturo Falaschi, and David Kowalski - Assembly of Pre-replication Complexes, 63
Umasundari Sivaprasad, Anindya Dutta, and Stephen P. Bell - Activation of Pre-replication Complexes, 89
Johannes C. Walter and Hiroyukio Araki - Eukaryotic DNA Replication Forks, 105
Peter M.J. Burgers and Yeon-Soo Seo - Chromatin Assembly, 121
Paul D. Kaufman and Genevíeve Almouzni - Inheritence of Genomic Methylation Patterns, 141
Robert A. Rollins, Marc Damelin, and Timothy H. Bestor - Termination of DNA Replication, 155
Deepak Bastia and Bidyut K. Mohanty - DNA Replication and Nuclear Architecture, 175
David M. Gilbert and Susan M. Gasser - Temporal Order of DNA Replication, 197
Anne D. Donaldson and Carl L. Schildkrewt - DNA Replication during Animal Development and Its Relevance to Gene Expression, 217
Damien Grégoire and Marcel Méchali - Developmental Gene Amplificaiton, 233
Brian R. Calvi - Plant Cells and Viruses, 257
Crisanto Gutierrez - Archeal, Bacterial, and Eukaryal DNA Replication Machines, 273
Stephen D. Bell
Regulation of DNA Replication and Cell Proliferation
- Regulating Initiation Events in yeats, 295
Etienne Schwob and Karim Labib - Regulating Initiation Events in Metazoa, 313
Melvin L. DePamphilis and J. Julian Blow - Responses to Aberrant DNA Replication and DNA Damage in Yeats, 335
Marco Foiani, Sanjay Kumar, and Joel A Huberman - Responses to Aberrant DNA Replication and DNA Damage in Metazoa, 357
Jean Gautier and Jiri Bartek
Cellular DNA Replication and Human Disease
- DNA Damage and Human Disease, 377
Errol C. Friedberg - DNA Polymerases and the Fidelity of DNA Replication, 391
Polina V. Scherbakova and Thomas A. Kunkel - The Role of RF-C and PCNA Proteins in Maintaining Genomic Stability, 411
Toshiki Tsurimoto - DNA Helicases and Human Disease, 435
Ashwini S. Kamath-Loeb, Michael Fry, and Lawrence A. Loeb - DNA Replication, Repeat Instability, and Human Disease, 461
John D. Cleary, Albert R. La Spada, and Christopher E. Pearson - DNA Replication and Cancer, 481
William C. Burhans, Antony M. Carr, and Geoffrey M. Wahl - Cancer Diagnosis and DNA Replication, 501
Nicholas Coleman, Anthony D. Mills, and Ronald A. Laskey - Pharmacological Agents That Target DNA Replication, 519
Yves Pommier and Robert B. Diasio - Mitochondrial DNA Replication and Human Disease, 547
David A. Clayton and Nils-Göran Larson - Telomere DNA Replication, Telomerase, and Human Disease, 561
David C.F. Sealy, Virginia A. Zakian, and Lea Harrington
Viral DNA Replication and Human Disease
- Parvovirus, 593
Susan F. Cotmore and Peter Tattersall - Papillomavirus, 609
Louise T. Chow and Thomas R. Broker - Polomavirus, 627
Ellen Fanning and James M. Pipas - Adenovirus, 645
Peter C. van der Vliet and Rob C. Hoeben - Herpes Simplex Virus, 663
Sandra K. Weller and Donald M. Coen - Epstein-Barr Virus, 687
Wolfgang Hammerschmidt and Bill Sugden - Poxvirus, 707
Bernard Moss and Frank De Silva - Hepadnavirus, 729
Christoph Seeger and William S. Mason
Appendix 1
A. Molecular Interaction Maps of DNA Replication, 745
Mirit I. Aladjem and Kurt W. Kohn
B. The Evolutionary History of Proteins Involved in Pre-replication Complex Assembly, 751
Lakshminarayan M. Iyer and L. Aravind
Appendix 2
Table I. Size and Complexity of Eukaryotic Genomes, 761
Table II. Names and Abbreviates for Organisms, Genes, and Protein Complexes, 762
Table III. Nomenclature for Proteins and Protein Complexes in Different Organisms, 766
Table IVA. Phyletic Distribution of Proteins Invovled in Pre-replication Complex Assembly, 778
Table IVB. Alternative Names for Orthologs, 780
Table V. Cellular Concentrations of Replication Origins and Pre-replication Complex Proteins, 782
Table VI. Human Diseases Associated with Defects in DNA Replication or Repair, 784
Table VII. Therapeutic Drugs That Target DNA Replication, 792
Index, 797
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