For the first time, researchers were able to track development of the human placenta from the merging of placental cells with blood vessels in the uterus to a fully formed organ using new ultrasound technology that visualizes and measures blood flow through extremely small blood vessels. The images and data provide a reference for typical placental development to help with comparison studies, tracking, identification of placental disorders, and other complications.
News
NICHD issues News Releases and Media Advisories to the news media. Spotlight and Research Feature articles explain NICHD research findings and public health issues to the general public. An Item of Interest is a short announcement of relevant information, such as a notable staff change.
Director's Corner: Reducing Ableism in Medicine and Research
Ableism—discrimination and social prejudice against those who are disabled—is a major contributor to the health disparities experienced by people with disabilities. Within NIH, NICHD has been at the forefront of efforts to address ableism in medicine and scientific research.
Science Update: Maternal microbiome promotes placental development in mice, NIH-funded study suggests
Bacteria in the maternal digestive tract appear to stimulate blood vessel development of the placenta, suggests a mouse study. Studying the relationship between the mother’s microbiome and placental development may yield important insights into fetal and maternal health.
Director's Corner: Addressing the Tragedy of Stillbirth
Each year, more than 20,000 families in the United States experience a stillbirth, the loss of a fetus at 20 weeks or more of gestation. Stillbirth is a traumatic event that takes a devastating, lifelong psychological toll on families. October marks Pregnancy and Infant Loss Awareness Month, making this an opportune time to reflect on the work we must do to better understand the causes of—and ultimately prevent—these tragedies.
Release: NIH launches $2 million prize competition to spur innovation in fetal diagnostic and monitoring technologies
NIH will award up to $2 million in cash prizes as part of its Fetal Monitoring Challenge to accelerate development of diagnostic and monitoring technologies that improve fetal health outcomes in low-resource settings. U.S. scientists, engineers, and clinicians can submit innovative approaches and compete for prizes and resources to support technology development and clinical impact, with a focus on point-of-care and home-based diagnostic and monitoring technologies that may reduce fetal health risk and loss during and after birth.
Spotlight: Scientific Advances from the Division of Intramural Research
The Division of Intramural Research provides fundamental knowledge about the nature and behavior of living systems through basic, clinical, and population-based research.
Science Update: MRI technique may predict impaired fetal growth and small size at birth, NIH-funded study suggests
A new imaging technique that measures the ability of the placenta to supply blood to the fetus may predict the chances of impaired fetal growth as early as the 14th week of pregnancy. The new method seems to allow earlier diagnosis than the standard ultrasound technique, which can detect reductions in placental blood flow at 20 to 24 weeks. Earlier detection of fetal growth restriction and risk of small for gestational age fetuses may lead to strategies for treating these conditions.
Director's Corner: Addressing the Health Effects of Climate Change
The effects of climate change on health are wide-ranging, from causing injuries and other medical concerns to disrupting vital supply chains. NICHD is committed to supporting scientific research to reduce climate-related health threats among its populations of interest—children, people of reproductive age, and people with intellectual and physical disabilities.
Release: NIH establishes Maternal Health Research Centers of Excellence
NIH has awarded $24 million in first-year funding to establish Maternal Health Research Centers of Excellence. The centers will develop and evaluate innovative approaches to reduce pregnancy-related complications and deaths and promote maternal health equity.
Science Update: Sleep-disordered breathing during mid-pregnancy may be linked to poor infant outcomes, NIH-funded study suggests
Infants born to mothers with sleep-disordered breathing—snoring, apnea, and other breathing difficulties during sleep—are more likely to develop complications such as jaundice, low blood sugar, seizures, or death during the newborn period, suggests a study funded by the National Institutes of Health. The authors called for studies to determine if treating mid-pregnancy, sleep-disordered breathing would improve infant outcomes.
Media Advisory: Cervical pessary no more effective than usual care in preventing preterm birth risk
A device known as a pessary, thought promising for reducing preterm birth risk due to a short cervix, appears no more effective than usual medical care, according to a study funded by the National Institutes of Health. A pessary is a rounded silicone device that fits around a cervix that has shortened, to keep it from opening and leading to miscarriage or preterm birth. The device is typically removed before the 37th week of pregnancy.
Science Update: NIH-funded study in macaques suggests cannabis use during pregnancy may alter offspring DNA expression
Offspring of female nonhuman primates given a cannabis product during pregnancy had changes in their DNA expression like those seen in human children with autism spectrum disorder and attention deficit hyperactivity disorder, according to a small study funded by the National Institutes of Health. The findings suggest that children whose mothers consume edibles or other products containing Delta-9-tetrahydrocannabinol (THC), the main psychoactive substance found in cannabis, could experience permanent developmental changes.
Item of Interest: NICHD-Developed Guide Sets Framework to Link Maternal, Infant Health Data
A new guide developed by NICHD and its partners promises to standardize the exchange of clinical data on maternal and infant health. The guide is an important step toward establishing a common framework to help clinicians and scientists better understand the root causes and high rates of maternal morbidity and mortality.
Item of Interest: NIH selects next round of winners in the Connecting the Community for Maternal Health Challenge
NIH has announced the next round of winners of its Connecting the Community for Maternal Health Challenge—a $3 million prize competition to encourage community-based and advocacy organizations in the United States to develop the infrastructure and capabilities necessary to conduct maternal health research.
Spotlight: Scientific Advances from the Division of Intramural Research
The Division of Intramural Research provides fundamental knowledge about the nature and behavior of living systems through basic, clinical, and population-based research.
Item of Interest: New policies needed for maternal health care among incarcerated people with COVID-19, according to NICHD-funded researchers
The health of pregnant individuals and new mothers in the nation’s prisons should be prioritized to avoid future public health crises from COVID-19, according to an analysis by NICHD-funded investigators. Recommended policy changes include early release, when possible, because pregnant people are at high risk from COVID-19, and prisons are not well-equipped to provide the necessary medical care. Moreover, prisons should promote COVID-19 vaccination and develop targeted messages for this population to counteract vaccine misinformation.
Release: “Eat, Sleep, Console” reduces hospital stay and need for medication among opioid-exposed infants
Researchers have found the “Eat, Sleep, Console” (ESC) care approach to be more effective than using the Finnegan Neonatal Abstinence Scoring Tool (FNAST) to assess and manage opioid-exposed newborns, according to a national clinical trial funded by the National Institutes of Health.
Science Update: Children born to women with COVID-19 could be at risk for heart disease, diabetes in later life, NIH-funded study suggests
Infants born in 2020 through mid-2021 to women with COVID-19 weighed less at birth, but grew at a faster rate than a comparable group born to women who did not have COVID-19, according to a study funded by the National Institutes of Health. Previous studies have found that preterm infants and other infants who are small or underweight at birth and who undergo catch-up growth in the first year are at higher risk for later life obesity, heart disease, high blood pressure and diabetes, compared to infants born at normal weight. The authors called for additional studies of infants whose mothers had COVID-19 during pregnancy to learn if they have increased health risks later in life.
Release: Tranexamic acid does not appear to prevent maternal hemorrhage after cesarean delivery
Tranexamic acid appears no more effective than placebo in reducing the need for blood transfusion or preventing maternal death in patients with increased risk for excessive bleeding because of cesarean delivery, according to a study funded by the National Institutes of Health. Tranexamic acid slows the natural breakdown of blood clots and was considered promising for reducing the risk of excessive bleeding after giving birth—known as postpartum hemorrhage—after cesarean delivery.
Item of Interest: NICHD announces awards for Maternal-Fetal Medicine Units Network
The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) has announced new funding for participating centers in its Maternal-Fetal Medicine Units (MFMU) Network.