Many cases of a rare disorder of the adrenal glands appear to result from two copies of a mutant gene, according to a research team made up of scientists in France and at the U.S. National Institutes of Health.
News
NICHD issues News Releases and Media Advisories to the news media. Spotlight and Research Feature articles explain NICHD research findings and public health issues to the general public. An Item of Interest is a short announcement of relevant information, such as a notable staff change.
NIH researchers identify candidate drug to treat Batten disease
Researchers at the National Institutes of Health have identified a potential new drug that could help in the treatment of a form of Batten disease, a fatal childhood disorder. The researchers tested the drug in mice with the disease and found that it slowed the loss of coordination seen in the disorder, and extended the animals’ life span.
NICHD podcast features research on adrenal gland disorders
This month’s NICHD Research Perspectives podcast focuses on adrenal gland disorders and research conducted by NICHD staff at the NIH Clinical Center.
Participants sought for NIH study of adrenal disorder
Adults who have congenital adrenal hyperplasia, a disorder of the adrenal glands, may be eligible to take part in a study at the National Institutes of Health on the effectiveness of a new pump which delivers missing adrenal hormones in a manner more closely matching their release by the adrenal glands.
New syndrome linked to a somatic HIF2A mutation
A team of NIH researchers, in collaboration with scientists from the University of Utah (Salt Lake City) and Tufts Medical Center (Boston), have identified a new syndrome involving two rare neuroendocrine tumors and a rare blood disease. The syndrome was observed in four female patients who had multiple paraganglioma and somatostatinoma tumors and the blood disease polycythemia.
Women’s, Men’s brains respond differently to hungry infant’s cries
Researchers at the National Institutes of Health have uncovered firm evidence for what many mothers have long suspected: women’s brains appear to be hard-wired to respond to the cries of a hungry infant.
New genetic link found between normal fetal growth and cancer
Two researchers at the National Institutes of Health discovered a new genetic link between the rapid growth of healthy fetuses and the uncontrolled cell division in cancer. The findings shed light on normal development and on the genetic underpinnings of common cancers.
Backwards signals appear to sensitize brain cells, rat study shows
When the mind is at rest, the electrical signals by which brain cells communicate appear to travel in reverse, wiping out unimportant information in the process, but sensitizing the cells for future sensory learning, according to a study of rats conducted by researchers at the National Institutes of Health.
Researchers describe role of trace minerals in health for February podcast
Trace minerals are minerals that the body needs in very small amounts: too little, or too much, can cause serious health problems. The February 2013 NICHD Research Perspectives featured efforts to better understand the role of iron and copper, two minerals important for human health.
Lack of iron regulating protein contributes to high blood pressure of the lungs
A protein known to regulate iron levels in the body has an unexpectedly important role in preventing a form of high blood pressure that affects the lungs, and in stabilizing the concentration of red cells in blood, according to a study in mice by researchers at the National Institutes of Health.
Immune system protein in semen boosts HIV spread in female genital tissue
An immune system protein normally found in semen appears to enhance the spread of HIV to tissue from the uterine cervix, according to researchers at the National Institutes of Health.
NIH clinical trial begins for treatment of rare, fatal neurological disorder
A clinical trial to evaluate a drug candidate called cyclodextrin as a possible treatment for Niemann-Pick disease type C1 (NPC), a rare and fatal genetic disease, will start on Wednesday, researchers announced today.
December NICHD Director’s podcast features primate research
This month’s podcast focuses on the research of NICHD’s Laboratory of Comparative Ethology.
November NICHD Director’s podcast now available
The November 2012 NICHD Director’s podcast is now online. This month’s podcast featured presenters from a recent NICHD Exchange program, “Sleep: the ABC’s of Zs.” The NICHD Exchange is a series of quarterly meetings in which NICHD administrators and scientists present relevant findings designed to spur thought provoking conversations to inform the NICHD research effort.
September NICHD Director's podcast now available
The September 2012 NICHD Research Perspectives, the NICHD’s monthly podcast, is now online. The podcast features discussions of research on how a gene found in a rare cancer increases red blood cell production, the involvement of “dark matter” DNA in the body’s response to day and night cycles, and on cesarean delivery versus labor for preterm infants.
Rare Cancers Yield Potential Source of Tumor Growth
Researchers at the National Institutes of Health have discovered a genetic mutation that appears to increase production of red blood cells in tumors. The discovery, based on analysis of tissue from rare endocrine tumors, may help clarify how some tumors generate a new blood supply to sustain their growth, the researchers explained.
New Video Highlights NIH Investment in Zebrafish Research
As they strive to develop new treatments for birth defects, or to prevent them, scientists at the National Institutes of Health have found a big ally in a small fish. An NIH video shows how the zebrafish, Danio rerio, is a valuable resource for scientists trying to understand the intricate process by which a fertilized egg develops into a fully formed individual, and the numerous diseases and conditions that can result when even a tiny part of the process goes wrong.
NICHD Launches New Director's Podcast Series
This month, the institute launched NICHD Research Perspectives, a new podcast series. Each month, NICHD Director Alan E. Guttmacher will talk with NICHD scientists and program staff about findings from their areas of expertise. The series provides a means for researchers to go beyond the descriptions in news releases, to discuss the implications of the research, what the findings may mean for patients and members of the public, as well as what direction future studies might take.
Audio Briefing: NIH Researchers Develop Nanoprobe Treatment for Animal Model of Cerebral Palsy
The Chief of NICHD's Perinatology Research Branch and his colleagues recently held a news briefing to describe a prototype treatment for an animal model of cerebral palsy. The researchers injected a bacterial toxin into the uteruses of pregnant rabbits. Like human patients with cerebral palsy, the baby rabbits developed a severe disability affecting their ability to move. When injected with nanoparticles carrying an anti-inflammatory drug, the baby rabbits recovered much of their movement ability.
NIH Brain Imaging Study Finds Evidence of Basis for Caregiving Impulse
Distinct patterns of activity--which may indicate a predisposition to care for infants--appear in the brains of adults who view an image of an infant face--even when the child is not theirs, according to a study by researchers at the National Institutes of Health and in Germany, Italy, and Japan.