Primary Ovarian Insufficiency (POI): NICHD Research Goals

In its aim to understand, treat, and prevent infertility, the NICHD conducts and supports laboratory research, clinical trials, and epidemiological studies that look at normal ovarian function and at how changes in that function impact overall health as well as fertility. Although much of this research is not specific to POI, our understanding of the condition benefits from these activities.

This research includes, but is not limited to:

  • Investigations in genetics, genomics, and epigenetics and studies about how these factors and processes influence typical and atypical development and function, including ovarian development and function
  • Basic biophysical mechanisms that underlie cell biology and tissue function and how these factors influence development that specifically targets the nervous, endocrine, and reproductive systems
  • Improving existing diagnostics and creating new methods for detecting and diagnosing endocrine, metabolic, and reproductive diseases
  • Integrated programs of basic, clinical, and translational research in developmental biology, endocrinology, neuroendocrinology, genetics, epigenetics, and other factors relevant to reproductive system disorders
  • Research on the quality of gametes (precursors of sperm and eggs)
  • Studies of the relationships among diet, reproduction, development, and infertility
  • Research on fertility preservation and on how these types of assisted reproductive technologies may affect health and developmental outcomes
top of pageBACK TO TOP