Pituitary tumors and other endocrine tumors lead to a variety of health problems in adults and children. NICHD research efforts aim to uncover the genetic abnormalities and molecular mechanisms that contribute to the development of pituitary tumors and related syndromes. Clinical studies aim to uncover methods of diagnosing, managing, and treating pituitary tumors in children.
The Institute also supports professional training and the development of research infrastructure that will facilitate investigations into childhood pituitary tumors.
NICHD research efforts related to pituitary tumors address the development of the pituitary gland itself as well as the development of pituitary tumors. Studies include efforts to understand the genetic, molecular, and cellular mechanisms of pituitary gland development. Using animal models, the Institute aims to document the gene mutations that lead to pituitary tumors. Studies in humans focus on genetic variations as well as diagnostic and therapeutic approaches to treating children and adults with pituitary tumors.
This research is supported in part through the NICHD's Developmental Biology and Structural Variation Branch (DBSVB), which focuses on the causes and prevention of congenital and genetic defects. Branch-supported research includes studies of:
Additionally, the Pediatric Growth and Nutrition Branch (PGNB) supports research on nutritional science, childhood antecedents of adult disease, developmental endocrinology, developmental neuroendocrinology, and physical growth and body composition, including bone health and obesity. The PGNB has supported research on the function and genetics of stem cells in the pituitary gland. Elucidating the dynamics of pituitary stem cells may lead to a better understanding of how pituitary tumors develop.
The Fertility and Infertility (FI) Branch supports scientific research aimed at alleviating human infertility, uncovering new leads on contraceptives, and expanding fundamental knowledge of the processes that underlie human reproduction. Research supported by the FI Branch has examined molecular and genetic mechanisms underlying the abnormal production of reproductive hormones as well as signaling in pathways involving the pituitary gland that affect male and female fertility.
Further research is being conducted within the Section on Endocrinology and Genetics (SEGEN), which is part of the Program on Developmental Endocrinology and Genetics (PDEGEN) in the NICHD's Division of Intramural Research. Researchers are investigating the genetics of rare endocrine disorders, including diseases that can lead to pituitary tumors. SEGEN scientists discovered how a mutation in the PRKAR1A gene can contribute to the development of Carney complex, a rare disorder characterized by tumors in the adrenal glands, heart, connective tissue, pituitary, and other glands.
The NICHD supports a number of research and clinical training programs for physicians. These programs are part of NIH-wide or collaborative efforts in which the NICHD participates. The training programs for pituitary research are listed below.
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