The NICHD conducts and supports a variety of clinical research projects related to pelvic pain. Select a link below to learn more about these projects.
Featured NICHD Clinical Trials on Pelvic Pain
- Botulinum Toxin for Pelvic Pain in Women with Endometriosis
Some women with endometriosis have chronic pelvic pain that may be caused by spasms of the pelvic floor muscles, which can be identified by examination. Preliminary studies suggest that botulinum toxin may be able to treat these muscle spasms and reduce the associated pain. This study is testing to see if botulinum toxin injections into the pelvic floor muscles can decrease pain and spasms in women with pelvic pain.
- The FIRSTT Study: Comparing MRgFUS (MR-guided Focused Ultrasound) and UAE (Uterine Artery Embolization) for Uterine Fibroids
This study is comparing the safety and effectiveness of two standard fibroid treatments: magnetic resonance imaging (MRI)-guided focused ultrasound surgery (MRgFUS) and uterine artery embolization (UAE). The study also will collect information to understand which symptoms bother women with fibroids the most.
- Global Study of Women's Health
The purpose of this study is to collect information about the impact of endometriosis among women worldwide, in terms of prevalence, diagnostic delay, quality of life, economic effect indicators, health care utilization, and risk factors. The study will help assess whether or how endometriosis-related pelvic pain differs from other kinds of pelvic pain.
- Pelvic Pain in Women with Endometriosis
This study is examining pelvic pain associated with endometriosis and examining better approaches to treatment. Standard treatments—altering hormone levels to prevent endometrial tissue growth or surgically removing endometrial tissue—treat pelvic pain only temporarily. This study is investigating the role of sex hormones, immune chemicals, stress hormones, and genes in pelvic pain, with the additional intent to determine how the nerve, muscle, and skeletal systems are involved in this pain.
- A Trial of Gabapentin in Vulvodynia: Biological Correlates of Response
This trial will test whether gabapentin can effectively reduce vulvar pain. More than 100 women are expected to enroll.
NICHD Clinical Trials
ClinicalTrials.gov Search Results
Information on current NIH-sponsored clinical trials on pelvic pain is available at the link below or by calling 1-800-411-1222.