The exact number of people with a premutation is unknown. Research shows that about 1 in 151 females and 1 in 468 males may have an FMR1 gene premutation, which puts them at risk for FXTAS.1 But not everyone with a premutation will show symptoms.
FXTAS is less common among women, and their symptoms are generally milder.2
In people with a premutation, 30% to 40% of men older than 503 and 8% of women older than age 50 will develop FXTAS.4
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