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Maraia, Richard J

Formal Title:

Senior Investigator





6 CENTER DR Room 2A02
Bethesda Md 20892
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Bethesda Md 20892

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Dr. Richard Maraia is a Senior Investigator and Head of the Section on Molecular and Cell Biology in the Intramural Research Program of the NICHD. Dr. Maraia directs a basic research program in Molecular Genetics that seeks to understand the influences of genetics, biochemistry and cell biology on the programmed metabolism of small nuclear RNAs and messenger RNAs, and how this contributes to growth and development. Of molecular interest is the structural plasticity of the human La antigen and related proteins in their ability to accommodate specific binding to a variety of RNAs that differ in sequence and structure. A major interest is in the biogenesis and metabolism of transfer RNAs, the genetic adapters that translate the genetic code, and the influences of their dynamics and relative abundances on codon bias-driven genetic programs involved in normal growth and in response to the physiologic states of stress and disease.

Dr. Maraia received his B.S. in Biological Sciences from Columbia University and his M.D. from Cornell University Medical College. He obtained specialty training in Pediatrics at The New York Hospital and in Medical Genetics at the NIH. Dr. Maraia's service currently includes Chairmanship of the NIH Regional RNA Club since 2005, and the International Biennial Conference on RNA Polymerases I & III (2010 & 2012), and he is the first President elect of the La and Related Protein (LARP) Society (2010-2014).

Publications (PubMed):

Title Authors Publication Date
Cellular La protein shields nonsegmented negative-strand RNA viral leader RNA from RIG-I and enhances virus growth by diverse mechanisms.Bitko V,Musiyenko A,Bayfield MA,Maraia RJ,Barik SJ Virol2008 Aug
Conserved and divergent features of the structure and function of La and La-related proteins (LARPs).Bayfield MA,Yang R,Maraia RJBiochim Biophys Acta2010 May-Jun
It's a mod mod tRNA world.Maraia RJ,Blewett NH,Bayfield MANat Chem Biol2008 Mar
Precursor-product discrimination by La protein during tRNA metabolism.Bayfield MA,Maraia RJNat Struct Mol Biol2009 Apr
Mouse and human La proteins differ in kinase substrate activity and activation mechanism for tRNA processing.Park JM,Intine RV,Maraia RJGene Expr2007
A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis.He N,Jahchan NS,Hong E,Li Q,Bayfield MA,Maraia RJ,Luo K,Zhou QMol Cell2008 Mar 14
Mutation of RNA Pol III subunit rpc2/polr3b Leads to Deficiency of Subunit Rpc11 and disrupts zebrafish digestive development.Yee NS,Gong W,Huang Y,Lorent K,Dolan AC,Maraia RJ,Pack MPLoS Biol2007 Nov
Conservation of a masked nuclear export activity of La proteins and its effects on tRNA maturation.Bayfield MA,Kaiser TE,Intine RV,Maraia RJMol Cell Biol2007 May
Separate RNA-binding surfaces on the multifunctional La protein mediate distinguishable activities in tRNA maturation.Huang Y,Bayfield MA,Intine RV,Maraia RJNat Struct Mol Biol2006 Jul
A role for TFIIIC transcription factor complex in genome organization.Noma K,Cam HP,Maraia RJ,Grewal SICell2006 Jun 2
The multifunctional RNA-binding protein La is required for mouse development and for the establishment of embryonic stem cells.Park JM,Kohn MJ,Bruinsma MW,Vech C,Intine RV,Fuhrmann S,Grinberg A,Mukherjee I,Love PE,Ko MS,DePamphilis ML,Maraia RJMol Cell Biol2006 Feb
The La protein-RNA complex surfaces.Maraia RJ,Bayfield MAMol Cell2006 Jan 20
Human La is found at RNA polymerase III-transcribed genes in vivo.Fairley JA,Kantidakis T,Kenneth NS,Intine RV,Maraia RJ,White RJProc Natl Acad Sci U S A2005 Dec 20
CK2 is responsible for phosphorylation of human La protein serine-366 and can modulate rpL37 5'-terminal oligopyrimidine mRNA metabolism.Schwartz EI,Intine RV,Maraia RJMol Cell Biol2004 Nov
Mutations in the RNA polymerase III subunit Rpc11p that decrease RNA 3' cleavage activity increase 3'-terminal oligo(U) length and La-dependent tRNA processing.Huang Y,Intine RV,Mozlin A,Hasson S,Maraia RJMol Cell Biol2005 Jan
Nonphosphorylated human La antigen interacts with nucleolin at nucleolar sites involved in rRNA biogenesis.Intine RV,Dundr M,Vassilev A,Schwartz E,Zhao Y,Zhao Y,Depamphilis ML,Maraia RJMol Cell Biol2004 Dec
RNA polymerase III from the fission yeast, Schizosaccharomyces pombe.Huang Y,Hamada M,Maraia RJMethods Enzymol2003
Differential phosphorylation and subcellular localization of La RNPs associated with precursor tRNAs and translation-related mRNAs.Intine RV,Tenenbaum SA,Sakulich AL,Keene JD,Maraia RJMol Cell2003 Nov
The fission yeast TFIIB-related factor limits RNA polymerase III to a TATA-dependent pathway of TBP recruitment.Huang Y,McGillicuddy E,Weindel M,Dong S,Maraia RJNucleic Acids Res2003 Apr 15
BCR/ABL activates mdm2 mRNA translation via the La antigen.Trotta R,Vignudelli T,Candini O,Intine RV,Pecorari L,Guerzoni C,Santilli G,Byrom MW,Goldoni S,Ford LP,Caligiuri MA,Maraia RJ,Perrotti D,Calabretta BCancer Cell2003 Feb
Methylphosphate cap structure in small RNAs reduces the affinity of RNAs to La protein.Bhattacharya R,Perumal K,Sinha K,Maraia R,Reddy RGene Expr2002
Transcription termination by the eukaryotic RNA polymerase III.Arimbasseri AG,Rijal K,Maraia RJBiochim Biophys Acta2012 Oct 23
RNA polymerase III mutants in TFIIFa-like C37 that cause terminator readthrough with no decrease in transcription output.Rijal K,Maraia RJNucleic Acids Res2012 Oct 23
tRNAomics: tRNA gene copy number variation and codon use provide bioinformatic evidence of a new anticodon:codon wobble pair in a eukaryote.Iben JR,Maraia RJRNA2012 Jul
Altered nuclear tRNA metabolism in La-deleted Schizosaccharomyces pombe is accompanied by a nutritional stress response involving Atf1p and Pcr1p that is suppressible by Xpo-t/Los1p.Cherkasova V,Maury LL,Bacikova D,Pridham K,Bähler J,Maraia RJMol Biol Cell2012 Feb
Plasticity and diversity of tRNA anticodon determinants of substrate recognition by eukaryotic A37 isopentenyltransferases.Lamichhane TN,Blewett NH,Maraia RJRNA2011 Oct
3' processing of eukaryotic precursor tRNAs.Maraia RJ,Lamichhane TNWiley Interdiscip Rev RNA2011 May
Point mutations in the Rpb9-homologous domain of Rpc11 that impair transcription termination by RNA polymerase III.Iben JR,Mazeika JK,Hasson S,Rijal K,Arimbasseri AG,Russo AN,Maraia RJNucleic Acids Res2011 Aug
Comparative whole genome sequencing reveals phenotypic tRNA gene duplication in spontaneous Schizosaccharomyces pombe La mutants.Iben JR,Epstein JA,Bayfield MA,Bruinsma MW,Hasson S,Bacikova D,Ahmad D,Rockwell D,Kittler EL,Zapp ML,Maraia RJNucleic Acids Res2011 Jun
La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability.Yang R,Gaidamakov SA,Xie J,Lee J,Martino L,Kozlov G,Crawford AK,Russo AN,Conte MR,Gehring K,Maraia RJMol Cell Biol2011 Feb
Aberrant nuclear trafficking of La protein leads to disordered processing of associated precursor tRNAs.Intine RV,Dundr M,Misteli T,Maraia RJMol Cell2002 May
La protein and its associated small nuclear and nucleolar precursor RNAs.Maraia RJ,Intine RVGene Expr2002
Widespread use of TATA elements in the core promoters for RNA polymerases III, II, and I in fission yeast.Hamada M,Huang Y,Lowe TM,Maraia RJMol Cell Biol2001 Oct
Comparison of the RNA polymerase III transcription machinery in Schizosaccharomyces pombe, Saccharomyces cerevisiae and human.Huang Y,Maraia RJNucleic Acids Res2001 Jul 1
La protein and the trafficking of nascent RNA polymerase iii transcripts.Maraia RJJ Cell Biol2001 May 14
Construction of FLAG and histidine tagging vectors for Schizosaccharomyces pombe.Huang Y,Hamada M,Patel J,Maraia RJYeast2001 Mar 30
Recognition of nascent RNA by the human La antigen: conserved and divergent features of structure and function.Maraia RJ,Intine RVMol Cell Biol2001 Jan
Control of transfer RNA maturation by phosphorylation of the human La antigen on serine 366.Intine RV,Sakulich AL,Koduru SB,Huang Y,Pierstorff E,Goodier JL,Phan L,Maraia RJMol Cell2000 Aug
Isolation and cloning of four subunits of a fission yeast TFIIIC complex that includes an ortholog of the human regulatory protein TFIIICbeta.Huang Y,Hamada M,Maraia RJJ Biol Chem2000 Oct 6
Transcription termination by RNA polymerase III in fission yeast. A genetic and biochemically tractable model system.Hamada M,Sakulich AL,Koduru SB,Maraia RJJ Biol Chem2000 Sep 15
Terminator-specific recycling of a B1-Alu transcription complex by RNA polymerase III is mediated by the RNA terminus-binding protein La.Goodier JL,Maraia RJJ Biol Chem1998 Oct 2
5' processing of tRNA precursors can Be modulated by the human La antigen phosphoprotein.Fan H,Goodier JL,Chamberlain JR,Engelke DR,Maraia RJMol Cell Biol1998 Jun
Heterodimer SRP9/14 is an integral part of the neural BC200 RNP in primate brain.Kremerskothen J,Zopf D,Walter P,Cheng JG,Nettermann M,Niewerth U,Maraia RJ,Brosius JNeurosci Lett1998 Apr 10
A carboxy-terminal basic region controls RNA polymerase III transcription factor activity of human La protein.Goodier JL,Fan H,Maraia RJMol Cell Biol1997 Oct
A highly conserved nucleotide in the Alu domain of SRP RNA mediates translation arrest through high affinity binding to SRP9/14.Chang DY,Newitt JA,Hsu K,Bernstein HD,Maraia RJNucleic Acids Res1997 Mar 15
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology