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Halvorson, LISA

Formal Title:



Chief, Gynecologic Health and Disease Branch





6710B ROCKLEDGE DRIVE Room 2440, MSC 7002
Bethesda ,MD 20817


Dr. Halvorson joined NICHD from the Dept. of OB/GYN at the University of Texas Southwestern Medical Center where she was a Professor in the Division of Reproductive Endocrinology and Infertility as well as a member of the Integrative Biology Graduate Program. She received her MD from Johns Hopkins Medical School in 1987, completed a residency in Obstetrics and Gynecology at Beth Israel Hospital in Boston, MA, and obtained subspecialty training in Reproductive Endocrinology and Infertility from Tufts/New England Medical Center.  She also pursued two post-doctoral fellowships, one at Massachusetts General Hospital and a second as a Reproductive Scientist Development Program Fellow at the Brigham and Women’s Hospital. Her personal research career was in the field of neuroendocrinology with a focus on characterization of the molecular mechanisms which regulate both normal and pathologic gonadotropin gene expression.  Funding for her work included NIH support since 1991. She is on the editorial boards for Reproductive Sciences, Endocrine Research, the American Journal of Physiology and the Journal of Experimental Biology and Medicine, and is an editor for the highly successful Williams Gynecology textbook. Dr. Halvorson has held multiple leadership roles both locally and nationally.  As Chief of the REI Division at UTSW from 2005‑2007, she directed the development of that institution's in vitro fertilization program. She sits on the Executive Committee of the NIH-Reproductive Scientist Development Program, is a member of the Society for Gynecologic Investigative Council (now the Society for Reproductive Investigation) and was a past member of NIH's Integrative and Clinical Endocrinology and Reproduction (ICER) Study Section.  In addition to caring for infertility patients, her clinical interests include fibroids, endometriosis, PCOS, and menstrual disorders.  

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Emphasis is on biomedical research on gynecologic health issues in women and adolescent girls.  Areas of interest include, but are not limited to:

1.      Development of new diagnostic approaches and treatments for female pelvic floor disorders, including drugs, graft materials, and devices used for non-surgical and surgical treatment of pelvic organ prolapse, urinary incontinence, and other female pelvic floor disorders.

2.      Development of new diagnostic approaches and treatments for uterine fibroids and endometriosis.

3.      Studies on the treatment of symptoms associated with abnormal menstrual cycles throughout the reproductive lifespan including the perimenopause/menopausal transition.

4.      Research on mechanisms, diagnosis and treatment of gynecologic pain disorders including chronic pelvic pain, vulvodynia and dysmenorrhea.


Publications (PubMed):

Efficacy of combined contraceptive vaginal ring versus oral contraceptive pills in achieving hypothalamic-pituitary-ovarian axis suppression in egg donor in vitro fertilization cycles.
PACAP modulates GnRH signaling in gonadotropes.
GATA augments GNRH-mediated increases in Adcyap1 gene expression in pituitary gonadotrope cells.
Androgen receptor drives transcription of rat PACAP in gonadotrope cells.
Interaction of gonadal steroids and gonadotropin-releasing hormone on pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP receptor expression in cultured rat anterior pituitary cells.
Identification of HESX1 mutations in Kallmann syndrome.
GnRH decreases adiponectin expression in pituitary gonadotropes via the calcium and PKA pathways.
Pituitary adenylate cyclase-activating polypeptide (PACAP) in the hypothalamic-pituitary-gonadal axis: a review of the literature.
Subclinical thyroid disease and the incidence of hypertension in pregnancy.
Antithyroid antibodies and parity: further evidence for microchimerism in autoimmune thyroid disease.
GATA transcription factors regulate LHß gene expression.
The orphan nuclear receptors COUP-TFI and COUP-TFII regulate expression of the gonadotropin LHß gene.
Pregnancy outcomes in women with thyroid peroxidase antibodies.
NELF is a nuclear protein involved in hypothalamic GnRH neuronal migration.
GnRH stimulates expression of PACAP in the pituitary gonadotropes via both the PKA and PKC signaling systems.
Pituitary tumors: diagnosis, management, and implications for reproduction.
Anterior pituitary gene expression with reproductive aging in the female rat.
Liver receptor homologue-1 regulates gonadotrope function.
Pituitary homeobox 1 (Pitx1) stimulates rat LHbeta gene expression via two functional DNA-regulatory regions.
Pituitary adenylate cyclase-activating polypeptide (PACAP) mimics neuroendocrine and behavioral manifestations of stress: Evidence for PKA-mediated expression of the corticotropin-releasing hormone (CRH) gene.
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