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Halvorson, LISA

Formal Title:



Chief, Gynecologic Health and Disease Branch





Bethesda Md 20892
For FedEx use:
Rockville Md 20852


Dr. Halvorson joined NICHD from the Dept. of OB/GYN at the University of Texas Southwestern Medical Center where she was a Professor in the Division of Reproductive Endocrinology and Infertility as well as a member of the Integrative Biology Graduate Program. She received her MD from Johns Hopkins Medical School in 1987, completed a residency in Obstetrics and Gynecology at Beth Israel Hospital in Boston, MA, and obtained subspecialty training in Reproductive Endocrinology and Infertility from Tufts/New England Medical Center.  She also pursued two post-doctoral fellowships, one at Massachusetts General Hospital and a second as a Reproductive Scientist Development Program Fellow at the Brigham and Women’s Hospital. Her personal research career was in the field of neuroendocrinology with a focus on characterization of the molecular mechanisms which regulate both normal and pathologic gonadotropin gene expression.  Funding for her work included NIH support since 1991. She is on the editorial boards for Reproductive Sciences, Endocrine Research, the American Journal of Physiology and the Journal of Experimental Biology and Medicine, and is an editor for the highly successful Williams Gynecology textbook. Dr. Halvorson has held multiple leadership roles both locally and nationally.  As Chief of the REI Division at UTSW from 2005‑2007, she directed the development of that institution's in vitro fertilization program. She sits on the Executive Committee of the NIH-Reproductive Scientist Development Program, is a member of the Society for Gynecologic Investigative Council (now the Society for Reproductive Investigation) and was a past member of NIH's Integrative and Clinical Endocrinology and Reproduction (ICER) Study Section.  In addition to caring for infertility patients, her clinical interests include fibroids, endometriosis, PCOS, and menstrual disorders.  

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Emphasis is on biomedical research on gynecologic health issues in women and adolescent girls.  Areas of interest include, but are not limited to:

1.      Development of new diagnostic approaches and treatments for female pelvic floor disorders, including drugs, graft materials, and devices used for non-surgical and surgical treatment of pelvic organ prolapse, urinary incontinence, and other female pelvic floor disorders.

2.      Development of new diagnostic approaches and treatments for uterine fibroids and endometriosis.

3.      Studies on the treatment of symptoms associated with abnormal menstrual cycles throughout the reproductive lifespan including the perimenopause/menopausal transition.

4.      Research on mechanisms, diagnosis and treatment of gynecologic pain disorders including chronic pelvic pain, vulvodynia and dysmenorrhea.


Publications (PubMed):

Title Authors Publication Date
Efficacy of combined contraceptive vaginal ring versus oral contraceptive pills in achieving hypothalamic-pituitary-ovarian axis suppression in egg donor in vitro fertilization cycles.Thomas RL,Halvorson LM,Carr BR,Doody KM,Doody KJJ Reprod Infertil2013 Oct
PACAP modulates GnRH signaling in gonadotropes.Halvorson LMMol Cell Endocrinol2014 Mar 25
GATA augments GNRH-mediated increases in Adcyap1 gene expression in pituitary gonadotrope cells.Thomas RL,Crawford NM,Grafer CM,Zheng W,Halvorson LMJ Mol Endocrinol2013 Dec
Androgen receptor drives transcription of rat PACAP in gonadotrope cells.Grafer CM,Halvorson LMMol Endocrinol2013 Aug
Interaction of gonadal steroids and gonadotropin-releasing hormone on pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP receptor expression in cultured rat anterior pituitary cells.Zheng W,Grafer CM,Halvorson LMReprod Sci2014 Jan
Identification of HESX1 mutations in Kallmann syndrome.Newbern K,Natrajan N,Kim HG,Chorich LP,Halvorson LM,Cameron RS,Layman LCFertil Steril2013 Jun
GnRH decreases adiponectin expression in pituitary gonadotropes via the calcium and PKA pathways.Kim J,Zheng W,Grafer C,Mann ML,Halvorson LMReprod Sci2013 Aug
Pituitary adenylate cyclase-activating polypeptide (PACAP) in the hypothalamic-pituitary-gonadal axis: a review of the literature.Thomas RL,Crawford NM,Grafer CM,Halvorson LMReprod Sci2013 Aug
Subclinical thyroid disease and the incidence of hypertension in pregnancy.Wilson KL,Casey BM,McIntire DD,Halvorson LM,Cunningham FGObstet Gynecol2012 Feb
Antithyroid antibodies and parity: further evidence for microchimerism in autoimmune thyroid disease.Greer LG,Casey BM,Halvorson LM,Spong CY,McIntire DD,Cunningham FGAm J Obstet Gynecol2011 Nov
GATA transcription factors regulate LHß gene expression.Lo A,Zheng W,Gong Y,Crochet JR,Halvorson LMJ Mol Endocrinol2011 Aug
The orphan nuclear receptors COUP-TFI and COUP-TFII regulate expression of the gonadotropin LHß gene.Zheng W,Horton CD,Kim J,Halvorson LMMol Cell Endocrinol2010 Dec 15
Pregnancy outcomes in women with thyroid peroxidase antibodies.Abbassi-Ghanavati M,Casey BM,Spong CY,McIntire DD,Halvorson LM,Cunningham FGObstet Gynecol2010 Aug
NELF is a nuclear protein involved in hypothalamic GnRH neuronal migration.Xu N,Bhagavath B,Kim HG,Halvorson L,Podolsky RS,Chorich LP,Prasad P,Xiong WC,Cameron RS,Layman LCMol Cell Endocrinol2010 May 5
GnRH stimulates expression of PACAP in the pituitary gonadotropes via both the PKA and PKC signaling systems.Grafer CM,Thomas R,Lambrakos L,Montoya I,White S,Halvorson LMMol Endocrinol2009 Jul
Pituitary tumors: diagnosis, management, and implications for reproduction.Beshay VE,Beshay JE,Halvorson LMSemin Reprod Med2007 Sep
Anterior pituitary gene expression with reproductive aging in the female rat.Zheng W,Jimenez-Linan M,Rubin BS,Halvorson LMBiol Reprod2007 Jun
Liver receptor homologue-1 regulates gonadotrope function.Zheng W,Yang J,Jiang Q,He Z,Halvorson LMJ Mol Endocrinol2007 Feb
Pituitary homeobox 1 (Pitx1) stimulates rat LHbeta gene expression via two functional DNA-regulatory regions.Jiang Q,Jeong KH,Horton CD,Halvorson LMJ Mol Endocrinol2005 Aug
Pituitary adenylate cyclase-activating polypeptide (PACAP) mimics neuroendocrine and behavioral manifestations of stress: Evidence for PKA-mediated expression of the corticotropin-releasing hormone (CRH) gene.Agarwal A,Halvorson LM,Legradi GBrain Res Mol Brain Res2005 Jul 29
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology