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Han, JOAN

Formal Title:

 

Responsibilities:

Pediatric endocrinology patient care, teaching of trainees in the fellowship program, and research on the neuroendocrine regulation of energy balance and neurocognitive function

Phone:

301-435-7820

Email:

joan.han@nih.gov

Address:

10 CENTER DR Room 1-3232
Bethesda Md 20892
For FedEx use:
Bethesda Md 20892

Biosketch:

Dr. Han received an A.B. from Harvard College and an M.D. from Harvard Medical School.  She completed residency in the Boston Combined Residency Program in Pediatrics at Children’s Hospital Boston and Boston Medical Center.  She received clinical research training at Nemours Children’s Clinic in Jacksonville, Florida, and completed pediatric endocrinology fellowship at the National Institutes of Health.  Since December 2009, she has been an Assistant Clinical Investigator and Head of the Unit on Metabolism and Neuroendocrinology in the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development. 

Her translational research aims to gain insight into the neuroendocrine regulation of human energy balance and neurocognitive function.  Clinical studies focus on patients with genetic disorders (e.g. MC4R mutation, Alstrom, Bardet-Biedl, Prader-Willi, Smith-Magenis, and WAGR/11p deletion syndromes) that are associated with childhood obesity and who frequently also display intellectual, psychiatric, and behavioral abnormalities. Candidate genes identified from these studies are further investigated in non-syndromic populations to determine if common genetic variants are associated with differences in body composition and neurocognition. The focus of laboratory investigations is elucidation of the mechanisms by which these genetic variants alter metabolism and neurodevelopment, with the goal of identifying deficit-specific therapies for obesity and neurocognitive impairment.

 

Publications (PubMed):

Amino-terminal propeptide of C-type natriuretic peptide (NTproCNP) predicts height velocity in healthy children.
Patients with Bardet-Biedl syndrome have hyperleptinemia suggestive of leptin resistance.
Effects of growth hormone and nutritional therapy in boys with constitutional growth delay: a randomized controlled trial.
Childhood obesity.
Lower brain-derived neurotrophic factor in patients with prader-willi syndrome compared to obese and lean control subjects.
Investigation of a patient with a partial trisomy 16q including the fat mass and obesity associated gene (FTO): fine mapping and FTO gene expression study.
Psychological symptoms and insulin sensitivity in adolescents.
Compound heterozygosity for mutations in PAX6 in a patient with complex brain anomaly, neonatal diabetes mellitus, and microophthalmia.
The stability of metabolic syndrome in children and adolescents.
The FTO gene rs9939609 obesity-risk allele and loss of control over eating.
Energy intake and energy expenditure among children with polymorphisms of the melanocortin-3 receptor.
Brain-derived neurotrophic factor and obesity in the WAGR syndrome.
Insulin resistance, hyperinsulinemia, and energy intake in overweight children.
Oxygen-uptake efficiency slope as a determinant of fitness in overweight adolescents.
Amino-terminal propeptide of C-type natriuretic peptide and linear growth in children: effects of puberty, testosterone, and growth hormone.
Influence of serum leptin on weight and body fat growth in children at high risk for adult obesity.
Evidence for hypermetabolism in boys with constitutional delay of growth and maturation.
Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene.
Association of brain-derived neurotrophic factor (BDNF) haploinsufficiency with lower adaptive behaviour and reduced cognitive functioning in WAGR/11p13 deletion syndrome.
Whole-exome sequencing identifies novel LEPR mutations in individuals with severe early onset obesity.
Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia.
Hyperphagia among patients with Bardet-Biedl syndrome.
Rapid and inexpensive screening of genomic copy number variations using a novel quantitative fluorescent PCR method.
Involvement of the neutral amino acid transporter SLC6A15 and leucine in obesity-related phenotypes.
Brain-derived neurotrophic factor in human subjects with function-altering melanocortin-4 receptor variants.
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology