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Levin, Henry L

Formal Title:

Senior Investigator

Responsibilities:

Head of the research program that studies the impact and function of transposable elements.

Phone:

301-402-4281

Email:

levinh@mail.nih.gov

Address:

18T CENTER DR Room 106, MSC 5431
Bethesda Md 20892-5431
For FedEx use:
Bethesda Md 20892

Topics in my portfolio:

Biosketch:

 

INSTITUTION AND LOCATION

DEGREE

(if applicable)

MM/YY

FIELD OF STUDY

Oberlin College, Oberlin

B.A.

5/81

Chemistry

University of California, Berkeley

Ph.D.

3/87

Molecular Biology

Johns Hopkins School of Medicine

Postdoctoral

11/92

Molecular Biology

 

 

 

 

 

 

 

 

 

 

Personal Statement

 

Henry Levin heads the Section on Eukaryotic Transposable Elements in the Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, which analyzes LTR retrotransposons as a model for the replication of retroviruses. Levin’s studies of LTR retrotransposons in fission yeast identified mechanistic details of particle formation, reverse transcription, and integration.  Recently, the laboratory demonstrated that Tf1 integration occurs primarily at promoters and used ultra-high throughput sequencing to generate a saturated map of sites targeted by Tf1. Dr. Levin has organized several conferences and symposia transposon biology and retrovirus replication.  With in the last year he has been a principal co-organizer for the ASM sponsored International Conference on Mobile DNA and the Retrovirus Meeting held at the Cold Spring Harbor Laboratories.  In 2009 he edited a special issue of the journal Methods on Transposon Technology and in 2011 he published a review of Transposon Biology in Nature Reviews Genetics. In 2011 Dr. Levin received the NIH Graduate Student Outstanding Mentor Award. 

 

Publications (PubMed):

Epigenetic Regulation of Condensin-Mediated Genome Organization during the Cell Cycle and upon DNA Damage through Histone H3 Lysine 56 Acetylation.
Dynamic interactions between transposable elements and their hosts.
Comparative functional genomics of the fission yeasts.
Determinants that specify the integration pattern of retrotransposon Tf1 in the fbp1 promoter of Schizosaccharomyces pombe.
High-throughput sequencing of retrotransposon integration provides a saturated profile of target activity in Schizosaccharomyces pombe.
The Hermes transposon of Musca domestica and its use as a mutagen of Schizosaccharomyces pombe.
The chromodomain of Tf1 integrase promotes binding to cDNA and mediates target site selection.
Retrotransposon Tf1 is targeted to Pol II promoters by transcription activators.
The GP(Y/F) domain of TF1 integrase multimerizes when present in a fragment, and substitutions in this domain reduce enzymatic activity of the full-length protein.
Chromodomains direct integration of retrotransposons to heterochromatin.
Host genome surveillance for retrotransposons by transposon-derived proteins.
The hermes transposon of Musca domestica is an efficient tool for the mutagenesis of Schizosaccharomyces pombe.
Stress management: how cells take control of their transposons.
The self primer of the long terminal repeat retrotransposon Tf1 is not removed during reverse transcription.
Specific recognition and cleavage of the plus-strand primer by reverse transcriptase.
The integrase of the long terminal repeat-retrotransposon tf1 has a chromodomain that modulates integrase activities.
The long terminal repeat-containing retrotransposon Tf1 possesses amino acids in gag that regulate nuclear localization and particle formation.
Retrotransposons and their recognition of pol II promoters: a comprehensive survey of the transposable elements from the complete genome sequence of Schizosaccharomyces pombe.
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology