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Mayer, Mark L

Formal Title:

Senior Investigator





35 CONVENT DR Room 3B1002, MSC 3712
Bethesda Md 20892-3712
For FedEx use:
Bethesda Md 20892

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Dr. Mayer was recruited to the NICHD as an Investigator after completing 7 years of postoctoral training. His lab works on the structure and function of ligand gated ion channels using X-ray diffraction, biochemical, and electrophysiological techniques. He received the Society for Neuroscience Young Investigator award in 1989 for work with Gary Westbrook on Ca permeability and Mg block of NMDA receptors and an NIH Merit award in 2003.

Dr. Mayer is listed in the ISI highly cited researchers data base. His H-index is 60 and papers from his lab have been cited more than 18,000 times by other groups. He has served on the NIH MDCN3 study section; the editorial boards of Molecular Pharmacology, The Journal of Neuroscience and The Journal of Neurophysiology; the tenure committees of NICHD and NINDS; and was chair of the 2004 Ion Channels Gordon Research Conference.

Publications (PubMed):

Title Authors Publication Date
Molecular basis of kainate receptor modulation by sodium.Plested AJ,Vijayan R,Biggin PC,Mayer MLNeuron2008 Jun 12
Conformational restriction blocks glutamate receptor desensitization.Weston MC,Schuck P,Ghosal A,Rosenmund C,Mayer MLNat Struct Mol Biol2006 Dec
Glutamate receptors at atomic resolution.Mayer MLNature2006 Mar 23
Crystal structures of the GluR5 and GluR6 ligand binding cores: molecular mechanisms underlying kainate receptor selectivity.Mayer MLNeuron2005 Feb 17
Regulation of AMPA receptor gating by ligand binding core dimers.Horning MS,Mayer MLNeuron2004 Feb 5
Mechanism of glutamate receptor desensitization.Sun Y,Olson R,Horning M,Armstrong N,Mayer M,Gouaux ENature2002 May 16
Zinc Potentiates GluK3 Glutamate Receptor Function by Stabilizing the Ligand Binding Domain Dimer Interface.Veran J,Kumar J,Pinheiro PS,Athané A,Mayer ML,Perrais D,Mulle CNeuron2012 Nov 8
Emerging models of glutamate receptor ion channel structure and function.Mayer MLStructure2011 Oct 12
Structure and assembly mechanism for heteromeric kainate receptors.Kumar J,Schuck P,Mayer MLNeuron2011 Jul 28
Domain organization and function in GluK2 subtype kainate receptors.Das U,Kumar J,Mayer ML,Plested AJProc Natl Acad Sci U S A2010 May 4
The N-terminal domain of GluR6-subtype glutamate receptor ion channels.Kumar J,Schuck P,Jin R,Mayer MLNat Struct Mol Biol2009 Jun
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