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Yanovski, Jack A

Formal Title:

Senior Investigator





10 CENTER DR Room 2-3142, MSC 1103
Bethesda Md 20892-1103
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Bethesda Md 20892

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Jack A. Yanovski, MD, PhD is Chief of the Section on Growth and Obesity in the Program on Developmental Endocrinology and Genetics. Dr. Yanovski obtained his medical degree in 1986 at the University of Pennsylvania, where he was also awarded a PhD in Physiological Psychology in 1989. After residency training in Pediatrics at the Children’s Hospital of Philadelphia, Dr. Yanovski completed a fellowship in Pediatric Endocrinology at the National Institutes of Health, conducting clinical and basic research with Gordon Cutler in the Section on Developmental Endocrinology in the Developmental Endocrinology Branch, where he developed the dexamethasone-suppressed ovine corticotropin-releasing hormone test for the differential diagnosis of hypercortisolism. This test has become part of the standard armamentarium of tests used by endocrinologists. Dr. Yanovski then remained at the National Institutes of Health to serve as Chief of Pediatrics for the Warren Grant Magnuson Clinical Center from 1994-1998. In response to the growing problem of pediatric obesity, Dr. Yanovski returned to NICHD to create the Unit on Growth and Obesity in the NICHD’s Developmental Endocrinology Branch and serve as its Head.

Dr. Yanovski has carried out a series of clinical studies related to the evaluation and treatment of overweight and obesity in children and adults, as well as laboratory investigations of the molecular etiologies of obesity. His randomized controlled trials have elucidated the limitations of current pharmacotherapeutic approaches for treatment of pediatric obesity and his observational studies have demonstrated the importance of disinhibited eating behaviors for pediatric obesity. His lab has also elucidated the roles of the melanocortin 3 receptor and brain-derived neurotrophic factor in human body weight regulation. Dr. Yanovski has authored or co-authored over 200 manuscripts and he has served as a regular reviewer for the New England Journal of Medicine, Lancet, JAMA, and many other journals. He has served as a standing member of the NSCF, NIH Study Section, as a consultant for FDA advisory panels, and on the editorial boards of several obesity, pediatric, and endocrine journals. Dr. Yanovski has also served as Chair of The Obesity Society’s annual Scientific Meeting. Among other awards, he has received the Public Health Service’s Outstanding Service Medal for innovative studies on obesity.

Publications (PubMed):

Title Authors Publication Date
Depressive symptoms and cardiorespiratory fitness in obese adolescents.Shomaker LB,Tanofsky-Kraff M,Zocca JM,Field SE,Drinkard B,Yanovski JAJ Adolesc Health2012 Jan
Pediatric obesity: etiology and treatment.Crocker MK,Yanovski JAPediatr Clin North Am2011 Oct
Longitudinal study of depressive symptoms and progression of insulin resistance in youth at risk for adult obesity.Shomaker LB,Tanofsky-Kraff M,Stern EA,Miller R,Zocca JM,Field SE,Yanovski SZ,Hubbard VS,Yanovski JADiabetes Care2011 Nov
Effects of metformin on body weight and body composition in obese insulin-resistant children: a randomized clinical trial.Yanovski JA,Krakoff J,Salaita CG,McDuffie JR,Kozlosky M,Sebring NG,Reynolds JC,Brady SM,Calis KADiabetes2011 Feb
Effects of high and low glycemic load meals on energy intake, satiety and hunger in obese Hispanic-American youth.Mirza NM,Klein CJ,Palmer MG,McCarter R,He J,Ebbeling CB,Ludwig DS,Yanovski JAInt J Pediatr Obes2011 Jun
Core body temperature in obesity.Heikens MJ,Gorbach AM,Eden HS,Savastano DM,Chen KY,Skarulis MC,Yanovski JAAm J Clin Nutr2011 May
Disordered-eating attitudes in relation to bone mineral density and markers of bone turnover in overweight adolescents.Schvey NA,Tanofsky-Kraff M,Yanoff LB,Checchi JM,Shomaker LB,Brady S,Savastano DM,Ranzenhofer LM,Yanovski SZ,Reynolds JC,Yanovski JAJ Adolesc Health2009 Jul
Energy intake and energy expenditure among children with polymorphisms of the melanocortin-3 receptor.Savastano DM,Tanofsky-Kraff M,Han JC,Ning C,Sorg RA,Roza CA,Wolkoff LE,Anandalingam K,Jefferson-George KS,Figueroa RE,Sanford EL,Brady S,Kozlosky M,Schoeller DA,Yanovski JAAm J Clin Nutr2009 Oct
Salience of loss of control for pediatric binge episodes: does size really matter?Shomaker LB,Tanofsky-Kraff M,Elliott C,Wolkoff LE,Columbo KM,Ranzenhofer LM,Roza CA,Yanovski SZ,Yanovski JAInt J Eat Disord2010 Dec
The FTO gene rs9939609 obesity-risk allele and loss of control over eating.Tanofsky-Kraff M,Han JC,Anandalingam K,Shomaker LB,Columbo KM,Wolkoff LE,Kozlosky M,Elliott C,Ranzenhofer LM,Roza CA,Yanovski SZ,Yanovski JAAm J Clin Nutr2009 Dec
The stability of metabolic syndrome in children and adolescents.Gustafson JK,Yanoff LB,Easter BD,Brady SM,Keil MF,Roberts MD,Sebring NG,Han JC,Yanovski SZ,Hubbard VS,Yanovski JAJ Clin Endocrinol Metab2009 Dec
Psychological symptoms and insulin sensitivity in adolescents.Shomaker LB,Tanofsky-Kraff M,Young-Hyman D,Han JC,Yanoff LB,Brady SM,Yanovski SZ,Yanovski JAPediatr Diabetes2010 Sep
High adiposity and high body mass index-for-age in US children and adolescents overall and by race-ethnic group.Flegal KM,Ogden CL,Yanovski JA,Freedman DS,Shepherd JA,Graubard BI,Borrud LGAm J Clin Nutr2010 Apr
Long-term ritonavir exposure increases fatty acid and glycerol recycling in 3T3-L1 adipocytes as compensatory mechanisms for increased triacylglycerol hydrolysis.Adler-Wailes DC,Guiney EL,Wolins NE,Yanovski JAEndocrinology2010 May
Eating patterns in youth with and without loss of control eating.Matheson BE,Tanofsky-Kraff M,Shafer-Berger S,Sedaka NM,Mooreville M,Reina SA,Vannucci A,Shomaker LB,Yanovski SZ,Yanovski JAInt J Eat Disord2012 Dec
Puberty and observed energy intake: boy, can they eat!Shomaker LB,Tanofsky-Kraff M,Savastano DM,Kozlosky M,Columbo KM,Wolkoff LE,Zocca JM,Brady SM,Yanovski SZ,Crocker MK,Ali A,Yanovski JAAm J Clin Nutr2010 Jul
Challenges and opportunities of defining clinical leptin resistance.Myers MG Jr,Heymsfield SB,Haft C,Kahn BB,Laughlin M,Leibel RL,Tschöp MH,Yanovski JACell Metab2012 Feb 8
Eating in the absence of hunger in adolescents: intake after a large-array meal compared with that after a standardized meal.Shomaker LB,Tanofsky-Kraff M,Zocca JM,Courville A,Kozlosky M,Columbo KM,Wolkoff LE,Brady SM,Crocker MK,Ali AH,Yanovski SZ,Yanovski JAAm J Clin Nutr2010 Oct
Acute effects of betahistine hydrochloride on food intake and appetite in obese women: a randomized, placebo-controlled trial.Ali AH,Yanoff LB,Stern EA,Akomeah A,Courville A,Kozlosky M,Brady SM,Calis KA,Reynolds JC,Crocker MK,Barak N,Yanovski JAAm J Clin Nutr2010 Dec
A prospective study of pediatric loss of control eating and psychological outcomes.Tanofsky-Kraff M,Shomaker LB,Olsen C,Roza CA,Wolkoff LE,Columbo KM,Raciti G,Zocca JM,Wilfley DE,Yanovski SZ,Yanovski JAJ Abnorm Psychol2011 Feb
Links between mothers' and children's disinhibited eating and children's adiposity.Zocca JM,Shomaker LB,Tanofsky-Kraff M,Columbo KM,Raciti GR,Brady SM,Crocker MK,Ali AH,Matheson BE,Yanovski SZ,Yanovski JAAppetite2011 Apr
Self-reported vs. actual energy intake in youth with and without loss of control eating.Wolkoff LE,Tanofsky-Kraff M,Shomaker LB,Kozlosky M,Columbo KM,Elliott CA,Ranzenhofer LM,Osborn RL,Yanovski SZ,Yanovski JAEat Behav2011 Jan
Obesity prevalence in the United States--up, down, or sideways?Yanovski SZ,Yanovski JAN Engl J Med2011 Mar 17
Patients with Bardet-Biedl syndrome have hyperleptinemia suggestive of leptin resistance.Feuillan PP,Ng D,Han JC,Sapp JC,Wetsch K,Spaulding E,Zheng YC,Caruso RC,Brooks BP,Johnston JJ,Yanovski JA,Biesecker LGJ Clin Endocrinol Metab2011 Mar
Adiposity and human regional body temperature.Savastano DM,Gorbach AM,Eden HS,Brady SM,Reynolds JC,Yanovski JAAm J Clin Nutr2009 Nov
An examination of the interpersonal model of loss of control eating in children and adolescents.Elliott CA,Tanofsky-Kraff M,Shomaker LB,Columbo KM,Wolkoff LE,Ranzenhofer LM,Yanovski JABehav Res Ther2010 May
Subtyping children and adolescents with loss of control eating by negative affect and dietary restraint.Goldschmidt AB,Tanofsky-Kraff M,Goossens L,Eddy KT,Ringham R,Yanovski SZ,Braet C,Marcus MD,Wilfley DE,Yanovski JABehav Res Ther2008 Jul
Loss of control eating disorder in children age 12 years and younger: proposed research criteria.Tanofsky-Kraff M,Marcus MD,Yanovski SZ,Yanovski JAEat Behav2008 Aug
Effects of ritonavir on adipocyte gene expression: evidence for a stress-related response.Adler-Wailes DC,Guiney EL,Koo J,Yanovski JAObesity (Silver Spring)2008 Oct
A prospective study of loss of control eating for body weight gain in children at high risk for adult obesity.Tanofsky-Kraff M,Yanovski SZ,Schvey NA,Olsen CH,Gustafson J,Yanovski JAInt J Eat Disord2009 Jan
Brain-derived neurotrophic factor and obesity in the WAGR syndrome.Han JC,Liu QR,Jones M,Levinn RL,Menzie CM,Jefferson-George KS,Adler-Wailes DC,Sanford EL,Lacbawan FL,Uhl GR,Rennert OM,Yanovski JAN Engl J Med2008 Aug 28
Laboratory assessment of the food intake of children and adolescents with loss of control eating.Tanofsky-Kraff M,McDuffie JR,Yanovski SZ,Kozlosky M,Schvey NA,Shomaker LB,Salaita C,Yanovski JAAm J Clin Nutr2009 Mar
Effects of calcium supplementation on body weight and adiposity in overweight and obese adults: a randomized trial.Yanovski JA,Parikh SJ,Yanoff LB,Denkinger BI,Calis KA,Reynolds JC,Sebring NG,McHugh TAnn Intern Med2009 Jun 16
Pediatric obesity: etiology and treatment.Crocker MK,Yanovski JAEndocrinol Metab Clin North Am2009 Sep
Validation of three food frequency questionnaires to assess dietary calcium intake in adults.Sebring NG,Denkinger BI,Menzie CM,Yanoff LB,Parikh SJ,Yanovski JAJ Am Diet Assoc2007 May
Oxygen-uptake efficiency slope as a determinant of fitness in overweight adolescents.Drinkard B,Roberts MD,Ranzenhofer LM,Han JC,Yanoff LB,Merke DP,Savastano DM,Brady S,Yanovski JAMed Sci Sports Exerc2007 Oct
A multisite investigation of binge eating behaviors in children and adolescents.Tanofsky-Kraff M,Goossens L,Eddy KT,Ringham R,Goldschmidt A,Yanovski SZ,Braet C,Marcus MD,Wilfley DE,Olsen C,Yanovski JAJ Consult Clin Psychol2007 Dec
Obesity-related hypoferremia is not explained by differences in reported intake of heme and nonheme iron or intake of dietary factors that can affect iron absorption.Menzie CM,Yanoff LB,Denkinger BI,McHugh T,Sebring NG,Calis KA,Yanovski JAJ Am Diet Assoc2008 Jan
Phenotype and course of Hutchinson-Gilford progeria syndrome.Merideth MA,Gordon LB,Clauss S,Sachdev V,Smith AC,Perry MB,Brewer CC,Zalewski C,Kim HJ,Solomon B,Brooks BP,Gerber LH,Turner ML,Domingo DL,Hart TC,Graf J,Reynolds JC,Gropman A,Yanovski JA,Gerhard-Herman M,Collins FS,Nabel EG,Cannon RO 3rd,Gahl WA,Introne WJN Engl J Med2008 Feb 7
Insulin resistance, hyperinsulinemia, and energy intake in overweight children.Han JC,Rutledge MS,Kozlosky M,Salaita CG,Gustafson JK,Keil MF,Fleisch AF,Roberts MD,Ning C,Yanovski JAJ Pediatr2008 May
Very low levels of energy expenditure among pre-adolescent Mexican-American girls.Dugas LR,Ebersole K,Schoeller D,Yanovski JA,Barquera S,Rivera J,Durazo-Arzivu R,Luke AInt J Pediatr Obes2008
Laboratory-Based Studies of Eating among Children and Adolescents.Tanofsky-Kraff M,Haynos AF,Kotler LA,Yanovski SZ,Yanovski JACurr Nutr Food Sci2007
Psychometric properties of a new questionnaire to assess eating in the absence of hunger in children and adolescents.Tanofsky-Kraff M,Ranzenhofer LM,Yanovski SZ,Schvey NA,Faith M,Gustafson J,Yanovski JAAppetite2008 Jul
Structure analysis of the Children's Eating Attitudes Test in overweight and at-risk for overweight children and adolescents.Ranzenhofer LM,Tanofsky-Kraff M,Menzie CM,Gustafson JK,Rutledge MS,Keil MF,Yanovski SZ,Yanovski JAEat Behav2008 Apr
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology