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Yanovski, Jack A

Formal Title:

Senior Investigator





10 CENTER DR Room 2-3142, MSC 1103
Bethesda Md 20892-1103
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Bethesda Md 20892

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Jack A. Yanovski, MD, PhD is Chief of the Section on Growth and Obesity in the Program on Developmental Endocrinology and Genetics. Dr. Yanovski obtained his medical degree in 1986 at the University of Pennsylvania, where he was also awarded a PhD in Physiological Psychology in 1989. After residency training in Pediatrics at the Children’s Hospital of Philadelphia, Dr. Yanovski completed a fellowship in Pediatric Endocrinology at the National Institutes of Health, conducting clinical and basic research with Gordon Cutler in the Section on Developmental Endocrinology in the Developmental Endocrinology Branch, where he developed the dexamethasone-suppressed ovine corticotropin-releasing hormone test for the differential diagnosis of hypercortisolism. This test has become part of the standard armamentarium of tests used by endocrinologists. Dr. Yanovski then remained at the National Institutes of Health to serve as Chief of Pediatrics for the Warren Grant Magnuson Clinical Center from 1994-1998. In response to the growing problem of pediatric obesity, Dr. Yanovski returned to NICHD to create the Unit on Growth and Obesity in the NICHD’s Developmental Endocrinology Branch and serve as its Head.

Dr. Yanovski has carried out a series of clinical studies related to the evaluation and treatment of overweight and obesity in children and adults, as well as laboratory investigations of the molecular etiologies of obesity. His randomized controlled trials have elucidated the limitations of current pharmacotherapeutic approaches for treatment of pediatric obesity and his observational studies have demonstrated the importance of disinhibited eating behaviors for pediatric obesity. His lab has also elucidated the roles of the melanocortin 3 receptor and brain-derived neurotrophic factor in human body weight regulation. Dr. Yanovski has authored or co-authored over 200 manuscripts and he has served as a regular reviewer for the New England Journal of Medicine, Lancet, JAMA, and many other journals. He has served as a standing member of the NSCF, NIH Study Section, as a consultant for FDA advisory panels, and on the editorial boards of several obesity, pediatric, and endocrine journals. Dr. Yanovski has also served as Chair of The Obesity Society’s annual Scientific Meeting. Among other awards, he has received the Public Health Service’s Outstanding Service Medal for innovative studies on obesity.

Publications (PubMed):

Depressive symptoms and cardiorespiratory fitness in obese adolescents.
Pediatric obesity: etiology and treatment.
Longitudinal study of depressive symptoms and progression of insulin resistance in youth at risk for adult obesity.
Effects of metformin on body weight and body composition in obese insulin-resistant children: a randomized clinical trial.
Effects of high and low glycemic load meals on energy intake, satiety and hunger in obese Hispanic-American youth.
Core body temperature in obesity.
Disordered-eating attitudes in relation to bone mineral density and markers of bone turnover in overweight adolescents.
Energy intake and energy expenditure among children with polymorphisms of the melanocortin-3 receptor.
Salience of loss of control for pediatric binge episodes: does size really matter?
The FTO gene rs9939609 obesity-risk allele and loss of control over eating.
The stability of metabolic syndrome in children and adolescents.
Psychological symptoms and insulin sensitivity in adolescents.
High adiposity and high body mass index-for-age in US children and adolescents overall and by race-ethnic group.
Long-term ritonavir exposure increases fatty acid and glycerol recycling in 3T3-L1 adipocytes as compensatory mechanisms for increased triacylglycerol hydrolysis.
Eating patterns in youth with and without loss of control eating.
Puberty and observed energy intake: boy, can they eat!
Challenges and opportunities of defining clinical leptin resistance.
Eating in the absence of hunger in adolescents: intake after a large-array meal compared with that after a standardized meal.
Acute effects of betahistine hydrochloride on food intake and appetite in obese women: a randomized, placebo-controlled trial.
A prospective study of pediatric loss of control eating and psychological outcomes.
Links between mothers' and children's disinhibited eating and children's adiposity.
Self-reported vs. actual energy intake in youth with and without loss of control eating.
Obesity prevalence in the United States--up, down, or sideways?
Patients with Bardet-Biedl syndrome have hyperleptinemia suggestive of leptin resistance.
Adiposity and human regional body temperature.
An examination of the interpersonal model of loss of control eating in children and adolescents.
Subtyping children and adolescents with loss of control eating by negative affect and dietary restraint.
Loss of control eating disorder in children age 12 years and younger: proposed research criteria.
Effects of ritonavir on adipocyte gene expression: evidence for a stress-related response.
A prospective study of loss of control eating for body weight gain in children at high risk for adult obesity.
Brain-derived neurotrophic factor and obesity in the WAGR syndrome.
Laboratory assessment of the food intake of children and adolescents with loss of control eating.
Effects of calcium supplementation on body weight and adiposity in overweight and obese adults: a randomized trial.
Pediatric obesity: etiology and treatment.
Validation of three food frequency questionnaires to assess dietary calcium intake in adults.
Oxygen-uptake efficiency slope as a determinant of fitness in overweight adolescents.
A multisite investigation of binge eating behaviors in children and adolescents.
Obesity-related hypoferremia is not explained by differences in reported intake of heme and nonheme iron or intake of dietary factors that can affect iron absorption.
Phenotype and course of Hutchinson-Gilford progeria syndrome.
Insulin resistance, hyperinsulinemia, and energy intake in overweight children.
Very low levels of energy expenditure among pre-adolescent Mexican-American girls.
Laboratory-Based Studies of Eating among Children and Adolescents.
Psychometric properties of a new questionnaire to assess eating in the absence of hunger in children and adolescents.
Structure analysis of the Children's Eating Attitudes Test in overweight and at-risk for overweight children and adolescents.
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