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Winer, Karen

Formal Title:

Medical Officer


Dr. Winer is the director of the pediatric endocrinology program which focuses on bone health, disorders of growth and puberty, metabolic syndrome, malnutrition, obesity, and diabetes. Her other areas of interest include studies related to the determinants of peak bone mass and muscle-bone interactions during infancy and childhood. Dr. Winer is the program director for the Child Health Research Centers, a national junior faculty level training program for pediatrician scientists.





6100 EXECUTIVE BLVD Room 4B11, MSC 7510
Bethesda Md 20892-7510
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Rockville Md 20852


Karen Winer, M.D., a board-certified pediatric endocrinologist, completed her pediatric residency training at the Mount Sinai Medical Center in New York, and her subspecialty training in pediatric endocrinology at the NIH. During her fellowship years, she was the first to study parathyroid hormone (PTH) replacement therapy in the treatment of hypoparathyroidism.  She established the safety and efficacy of PTH delivered by single and multiple daily injections. Recently, she further optimized PTH replacement therapy through the use of a continuous pump in both adults and children.   Dr. Winer joined the Endocrinology, Nutrition, Growth Branch in 1998 to direct and develop programs in pediatric endocrinology, bone health, and osteoporosis prevention.  In 2001, she established Diabetes Research in Children Network (DirecNet) to develop the artificial pancreas.   Additionally, she established another highly acclaimed pediatric research network, the Bone Mineral Density in Childhood Study (BMDCS).  She has received the NIH Director’s and the NICHD Director’s awards for her work.  She is a member of the editorial board of the Journal of Clinical Endocrinology and Metabolism.


Featured Items:

Winer K, Levin E, Grave G, Alexander D The Child Health Research Centers Program: 1990-2000. J Pediatr 2001;139:767.

Diabetes Research in Children Network (DirecNet) Study Group. Lack of Accuracy of Continuous Glucose Sensors in Healthy, Nondiabetic Children: Results of the Diabetes Research in Children Network (DirecNet) Accuracy Study. J Pediatr. 2004 Jun; 144(6): 770-5.

Diabetes Research in Children Network (DirecNet) Study Group: The effects of aerobic exercise on glucose and counter-regulatory hormone concentrations in children with type 1 diabetes. Diabetes Care 2006 29:20-25.

Diabetes Research in Children Network (Direcnet) Study Group: Impact of exercise on overnight glycemic control in children with type 1 diabetes. J Pediatr 2005 147:528-534.

Kalkwarf H, Gilsanz V, Lappe JM, Oberfield S, Shepherd JA, Frederick MM, Winer KK, Zemel BS Tracking of Bone Mass and Density during Childhood and Adolescence J Clin Endocrinol Metab. 2010;95:1690.

Winer KK,. Yanovski JA, and Cutler, G.B., Jr. Synthetic Human Parathyroid Hormone 1-34 vs. Calcitriol in the Treatment of Hypoparathyroidism: Results of a Randomized Trial JAMA 1996; 276; 631-6

Winer KK, Yanovski JA, Sarani B, Cutler GB  A Randomized Crossover Trial of Once Daily Vs. Twice Daily Parathyroid Hormone in the Treatment of Hypoparathyroidism. J Clin Endocrinol Metab. 83: 3480-86, 1998.


Publications (PubMed):

Title Authors Publication Date
The child health research centers: twenty-one years of promoting the development of pediatrician scientists from 1990-2011.Winer KK,Rothenberg ME,Guimond J,Handwerger S,Boxer LA,Grave G,Devaskar SU,Castle VPJ Pediatr2012 Dec
Racial Disparity in Fracture Risk between White and Nonwhite Children in the United States.Wren TA,Shepherd JA,Kalkwarf HJ,Zemel BS,Lappe JM,Oberfield S,Dorey FJ,Winer KK,Gilsanz VJ Pediatr2012 Dec
Synthetic human parathyroid hormone 1-34 replacement therapy: a randomized crossover trial comparing pump versus injections in the treatment of chronic hypoparathyroidism.Winer KK,Zhang B,Shrader JA,Peterson D,Smith M,Albert PS,Cutler GB JrJ Clin Endocrinol Metab2012 Feb
Optimal monitoring time interval between DXA measures in children.Shepherd JA,Wang L,Fan B,Gilsanz V,Kalkwarf HJ,Lappe J,Lu Y,Hangartner T,Zemel BS,Fredrick M,Oberfield S,Winer KKJ Bone Miner Res2011 Nov
Revised reference curves for bone mineral content and areal bone mineral density according to age and sex for black and non-black children: results of the bone mineral density in childhood study.Zemel BS,Kalkwarf HJ,Gilsanz V,Lappe JM,Oberfield S,Shepherd JA,Frederick MM,Huang X,Lu M,Mahboubi S,Hangartner T,Winer KKJ Clin Endocrinol Metab2011 Oct
Forum on aging and skeletal health: summary of the proceedings of an ASBMR workshop.Khosla S,Bellido TM,Drezner MK,Gordon CM,Harris TB,Kiel DP,Kream BE,LeBoff MS,Lian JB,Peterson CA,Rosen CJ,Williams JP,Winer KK,Sherman SSJ Bone Miner Res2011 Nov
Age at onset of puberty predicts bone mass in young adulthood.Gilsanz V,Chalfant J,Kalkwarf H,Zemel B,Lappe J,Oberfield S,Shepherd J,Wren T,Winer KJ Pediatr2011 Jan
Long-term treatment of 12 children with chronic hypoparathyroidism: a randomized trial comparing synthetic human parathyroid hormone 1-34 versus calcitriol and calcium.Winer KK,Sinaii N,Reynolds J,Peterson D,Dowdy K,Cutler GB JrJ Clin Endocrinol Metab2010 Jun
Tracking of bone mass and density during childhood and adolescence.Kalkwarf HJ,Gilsanz V,Lappe JM,Oberfield S,Shepherd JA,Hangartner TN,Huang X,Frederick MM,Winer KK,Zemel BSJ Clin Endocrinol Metab2010 Apr
Height adjustment in assessing dual energy x-ray absorptiometry measurements of bone mass and density in children.Zemel BS,Leonard MB,Kelly A,Lappe JM,Gilsanz V,Oberfield S,Mahboubi S,Shepherd JA,Hangartner TN,Frederick MM,Winer KK,Kalkwarf HJJ Clin Endocrinol Metab2010 Mar
Effects of once versus twice-daily parathyroid hormone 1-34 therapy in children with hypoparathyroidism.Winer KK,Sinaii N,Peterson D,Sainz B Jr,Cutler GB JrJ Clin Endocrinol Metab2008 Sep
The bone mineral density in childhood study: bone mineral content and density according to age, sex, and race.Kalkwarf HJ,Zemel BS,Gilsanz V,Lappe JM,Horlick M,Oberfield S,Mahboubi S,Fan B,Frederick MM,Winer K,Shepherd JAJ Clin Endocrinol Metab2007 Jun
Long-term treatment of hypoparathyroidism: a randomized controlled study comparing parathyroid hormone-(1-34) versus calcitriol and calcium.Winer KK,Ko CW,Reynolds JC,Dowdy K,Keil M,Peterson D,Gerber LH,McGarvey C,Cutler GB JrJ Clin Endocrinol Metab2003 Sep
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology