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Video Text Alternative: Endometriosis Symptoms and Causes: A Meet Our Researchers Video

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To view the original video, please go to http://www.nichd.nih.gov/news/profiles/KnowNICHD/eisenberg/Pages/default.aspx

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Endometriosis Symptoms and Causes: An NICHD Meet Our Researchers Video

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Camera view of Dr. Esther Eisenberg.

Banner Text: Esther Eisenberg, M.D. Fertility & Infertility Branch, NICHD
Dr. Esther Eisenberg: Endometriosis is a condition that can cause infertility, and so, to that extent, it is one of the areas that we work in.
(Edit/camera cut) Dr. Eisenberg on camera. Dr. Eisenberg: We fund research in that area if it involves infertility, and also, as part of the Reproductive Medicine Network, we are developing clinical trial protocols that involve women who have infertility and endometriosis. And also, …
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Still image of a researcher in a lab.
Dr. Eisenberg: … we are currently developing a protocol to identify, …
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Still image of a pensive couple consulting with a health care provider.
Dr. Eisenberg: … potentially, a noninvasive diagnostic marker of endometriosis.
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Still image of a smiling couple consulting with a health care provider.
Dr. Eisenberg: We don't really know what causes it, but we know that …
Dr. Eisenberg on camera. Dr. Eisenberg: … it may be related to …
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Animated video of the female reproductive system. The uterus, fallopian tubes, ovaries, vagina, and endometrium (uterine lining) are labeled. Animation shows typical menstrual flow, then depicts the process of retrograde menstruation and endometriosis. The system is shown with areas of endometriosis on a silhouette of  the peritoneal (abdominal) cavity. "Called 'retrograde menstruation' " appears at the bottom of the screen in addition to labels for the peritoneal cavity and the areas of endometriosis.
Dr. Eisenberg: … the fact that when women menstruate, some of their uterine lining, which is part of the menstrual tissue that is shed, sometimes flows backward through the fallopian tubes and deposits in the—what we call—peritoneal cavity. So basically, that is the…
Dr. Eisenberg on camera. Dr. Eisenberg: … lining areas and the whole abdominal cavity in which the uterus, fallopian tubes, and ovaries are located.
(Edit/camera cut) Dr. Eisenberg on camera. Dr. Eisenberg: With this what we call retrograde menstruation and the deposition of the endometrial tissue, sometimes that tissue implants in the reproductive organs…
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Animated video of a female reproductive system with endometriosis located on the ovaries and uterus. The uterus, fallopian tubes, ovaries, vagina, and areas of endometriosis are labeled.
Dr. Eisenberg: … or other areas and is responsive to the hormones of the menstrual cycle. But in women with endometriosis, during their menstrual cycle, this tissue has...
Dr. Eisenberg on camera. Dr. Eisenberg: … a life of its own and can bleed and can cause inflammatory reactions and can cause scar tissue, and then those things can lead to infertility and pelvic pain and some of the symptoms that are related to endometriosis.
(Edit/camera cut) Dr. Eisenberg on camera. Dr. Eisenberg: Women with endometriosis often…
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Still image of a close-up of a woman's hands clutching her abdomen.
Dr. Eisenberg: … do have painful menstrual periods. Pain with intercourse is a symptom that...
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Still image of a woman consulting with her health care provider.
Dr. Eisenberg: … many women will experience. And one of the problems with endometriosis is that it may go…
Dr. Eisenberg on camera. Dr. Eisenberg: … undiagnosed for quite a while and, in many women, will only be diagnosed once they experience infertility or if they're having severe pelvic pain.
(Edit/camera cut) Dr. Eisenberg on camera. Dr. Eisenberg: Recently, a study was…
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Still image of an article on the NICHD website scrolls up the screen. Headline reads, "High-tech analysis of genetic data may yield new test for endometriosis."
Dr. Eisenberg: … completed; the goal was to identify a way of diagnosing endometriosis that didn't involve…
Dr. Eisenberg on camera. Dr. Eisenberg: … a surgical diagnosis. So this would involve obtaining tissue…
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Video of a researcher in a lab.
Dr. Eisenberg: … from the uterine lining and then…
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Video of a close-up of a researcher handling lab materials.
Dr. Eisenberg: … looking at certain genetic markers in…
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Video of a close-up of a set of test tubes.
Dr. Eisenberg: … that tissue, and if there is a specific…
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Video of a close-up of a researcher inserting a pipette into a test tube.
Dr. Eisenberg: … group of markers—so almost like…
Dr. Eisenberg on camera. Dr. Eisenberg: … a fingerprint of endometriosis—then that person could be diagnosed. Now, this has been looked at in a small group of endometrial biopsy samples and needs to be validated in a larger sample.
(Edit/camera cut) Dr. Eisenberg on camera. Dr. Eisenberg: I think that endometriosis is such a broad field. I think that we need to chip at it in many directions. It's almost like having a large…
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Animated video of a jigsaw puzzle coming together. The puzzle has four pieces, which are labeled Cause, Treatment, Symptoms, and Diagnosis.
Dr. Eisenberg: … jigsaw puzzle, and you have certain parts of it where you have put together the different shapes, but you still don't know what the whole picture is. And so, I think we just need to…
Dr. Eisenberg on camera. Dr. Eisenberg: … keep working at it, piece by piece, so that we have a better understanding.
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