Skip Navigation
  Print Page

Segars Lab: Unit on Reproductive Endocrinology and Infertility

Skip sharing on social media links
Share this:
Skip Internal Navigation

Overview

James Segars, who heads the Unit on Reproductive Endocrinology and Infertility, and his colleagues addressed disparities in access to reproductive services and treatment. Collaborative work established a complex relationship between the BRX gene complex and fibroid generation, and the Unit is expanding its work on several aspects of fibroids, including gene regulation and growth factors. With regard to fertility, the Walter Reed Army Medical Center s Assisted Reproductive Technologies Program continues to provide material for clinical studies. The Oocyte Physician Program, involving investigators at the NIH and the laboratory of Jacques Cohen in Livingston, New Jersey, looked at the effect of leiomyomas on early pregnancy, anti-M llerin hormone pre- and post-myomectomy, and ovarian reserves in patients with fibroids. A new area of investigation has been the assessment and preservation of ovarian function in women and girls undergoing cancer treatment. Another area of investigation is to assess whether obesity causes abnormal endometrial development. Several studies correlate endometrial thickness with pregnancy success; however, no study demonstrates a relationship between BMI, circulating E2 levels, and endometrial thickness. The Unit is thus examining the influence of BMI on endometrial development and E2 levels during ovarian stimulation with an IUI.

Last Updated Date: 11/30/2012
Last Reviewed Date: 11/30/2012

Contact Information

Name: Dr James Segars
Staff Clinician
Program in Reproductive and Adult Endocrinology
Phone: 301-496-5800
Fax: 301-402-0884
E-mail: segarsj@mail.nih.gov

Staff Directory
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology