The Section on Analytical and Functional Biophotonics, led by Amir Gandjbakhche, devises quantitative biophotonics methodologies and associated instrumentation to study biological phenomena at various length scales, from nanoscopic to microscopic. The Section focuses on translation of technologies and methodologies to the bedside. At the pre-clinical level, the SAFB uses a near-infrared, scanning, time-resolved imaging system to specifically quantify HER-2 receptors in tumor xenografts, with the goal developing a non invasive immune-imaging system. At the "bedside" level, the Section (i) designed an optical camera, mounted in a conventional colposcope for active polarization imaging of cervical texture while improving statistical tools to enhance visualization of hidden structures (clinical protocol 09-CH-0180); (ii) developed real-time algorithms to assess vascularity in AIDS-associated Kaposi's sarcoma (clinical protocol 08-CH-0001); (iii) developed near-infrared spectroscopy (NIRS) as a noninvasive technique for measuring the local changes in cerebral hemodynamic levels associated with brain activity. The NIRS technique will be used on populations that include patients with traumatic brain injury (TBI), e.g., children and veterans, and patients with autistic-spectrum disorder. The goal of the project is to develop a small and portable near infrared instrument with novel neuro-imaging capabilities and translate it to the bedside for use in hospital environments (clinical protocol 10-CH-0198).
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