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Macfarlan Lab: Unit on Mammalian Epigenome Reprogramming

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Scientific Articles

  • Macfarlan TS, Gifford WD, Driscoll S, Rowe HM, Bonanomi D, Lettieri K, Firth A, Singer O, Trono D, and Pfaff SL. Embryonic stem cell potency fluctuates with endogenous retrovirus activity. Nature in press. doi10.1038/nature11244.

  • Macfarlan TS, Gifford WD, Agarwal SA, Driscoll S, Lettieri K, Wang J, Andrews SE, Franco L, Rosenfeld MG, Ren B, and Pfaff SL. Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A. Genes Dev. Published in Advance February 28, 2011. doi:10.1101/gad.2008511 PMID: 21357675

  • Pfaff, S.L. and Macfarlan, T. (2008) Transcriptional networks and the spinal cord. In: Encyclopedia of Neuroscience. Book Chapter, Editor in chief L. R. Squire, 1093-1098.

  • Loomis RJ, Naoe Y, Parker JB, Savic V, Bozovsky MR, Macfarlan T, Manley JL, Chakravarti D. (2009) Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylation. Mol Cell. 2009 Feb 27;33(4):450-61. PMID: 19250906

  • Macfarlan T, Parker JB, Nagata K, Chakravarti D. (2005) Thanatos-associated protein 7 associates with template activating factor-Ibeta and inhibits histone acetylation to repress transcription. Mol Endocrinol. 2006 Feb;20(2):335-47. Epub 2005 Sep 29. PMID: 16195249

  • Macfarlan T, Kutney S, Altman B, Montross R, Yu J, Chakravarti D. (2005) Human THAP7 is a chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressor. J Biol Chem. 2005 Feb 25;280(8):7346-58. Epub 2004 Nov 23. PMID: 15561719

  • Hong R, Macfarlan T, Kutney SN, Seo SB, Mukai Y, Yelin F, Pasternack GR, Chakravarti D. (2004) The identification of phosphorylation sites of pp32 and biochemical purification of a cellular pp32-kinase. Biochemistry. 2004 Aug 10;43(31):10157-65. PMID: 15287743

  • Kutney SN, Hong R, Macfarlan T, Chakravarti D. (2004) A signaling role of histone-binding proteins and INHAT subunits pp32 and Set/TAF-Ibeta in integrating chromatin hypoacetylation and transcriptional repression. J Biol Chem. 2004 Jul 16;279(29):30850-5. Epub 2004 May 10. PMID: 15136563

  • Li F, Macfarlan T, Pittman RN, Chakravarti D. (2002) Ataxin-3 is a histone-binding protein with two independent transcriptional corepressor activities. J Biol Chem. 2002 Nov 22;277(47):45004-12. Epub 2002 Sep 23. PMID: 12297501

  • Seo SB, Macfarlan T, McNamara P, Hong R, Mukai Y, Heo S, Chakravarti D. (2002) Regulation of histone acetylation and transcription by nuclear protein pp32, a subunit of the INHAT complex. J Biol Chem. 2002 Apr 19;277(16):14005-10. Epub 2002 Feb 5. PMID: 11830591

  • Pöhlmann S, Leslie GJ, Edwards TG, Macfarlan T, Reeves JD, Hiebenthal-Millow K, Kirchhoff F, Baribaud F, Doms RW. (2001) DC-SIGN interactions with human immunodeficiency virus: virus binding and transfer are dissociable functions. J Virol. 2001 Nov;75(21):10523-6. PMID: 11581425

  • Baribaud F, Pöhlmann S, Sparwasser T, Kimata MT, Choi YK, Haggarty BS, Ahmad N, Macfarlan T, Edwards TG, Leslie GJ, Arnason J, Reinhart TA, Kimata JT, Littman DR, Hoxie JA, Doms RW. (2001) Functional and antigenic characterization of human, rhesus macaque, pigtailed macaque, and murine DC-SIGN. J Virol. 2001 Nov;75(21):10281-9. PMID: 11581396

Last Reviewed: 12/06/2012

Contact Information

Name: Dr Todd Scott Macfarlan
Unit on Mammalian Epigenome Reprogramming
Phone: 301-594-9175

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