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Love Lab: Section on Cellular and Developmental Biology

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The Section on Cellular and Developmental Biology, led by Paul Love, studies mammalian hematopoietic development. A main area of research concerns T lymphocyte development, particularly signal transduction molecules and pathways that regulate T cell maturation in the thymus. The group revealed a critical function for T cell antigen receptor (TCR) signaling in controlling key developmental events essential for the prevention of autoimmunity and recently described a previously unknown T cell–specific protein, Themis, which functions to sustain TCR signaling during T cell development. Additional studies identified an essential function for the nuclear adapter LIM domain protein-1 in hematopoietic stem cell maintenance and erythropoiesis.

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Last Reviewed: 11/30/2012

Contact Information

Name: Dr Paul Love
Senior Investigator
Section on Cellular and Developmental Biology
Phone: 301-402-4946
Fax: 301-480-6302

Staff Directory
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology