Skip Ribbon Commands
Skip to main content
  Print Page

Judith Levin Lab: Section on Viral Gene Regulation

Skip sharing on social media links
Share this:
Skip Internal Navigation ​​​​


Judith Levin and colleagues in the Section on Viral Gene Regulation study the molecular aspects of HIV-1 replication. A major focus is the critical role of the viral nucleocapsid protein (NC), a nucleic acid chaperone that remodels nucleic acid structures and is required for almost all steps in reverse transcription. The Section demonstrated that the Gag precursor (through its NC domain) also has chaperone activity, although at high concentrations, Gag severely inhibits DNA elongation. Based on this finding, the group proposed a novel roadblock mechanism for regulating reverse transcription. Ongoing functional analysis of HIV-1 capsid protein has revealed the importance of the interdomain linker region for proper core assembly and stability. Additionally, the group is investigating the molecular properties and three-dimensional structure of human APOBEC3A, a restriction factor that blocks LINE-1 retrotransposition.


​​​​​​​​​​​​​​ ​​​​​​​​​​
Last Updated Date: 11/30/2012
Last Reviewed Date: 11/30/2012

Contact Information

Name: Dr Judith G Levin
Senior Investigator
Laboratory of Molecular Genetics
Phone: 301-496-1970
Fax: 301-496-0243

Staff Directory