A major effort of the Human Genetics Section, led by Bruce Howard, focuses on epigenome structure, including higher-order chromatin architecture and DNA methylation patterns. The group pays special attention to how defects in the maintenance of epigenetic structures (or failures in programmed transitions, especially in the perinatal period) may underlie common developmental disorders and age-related diseases. The group develops and implements bioinformatic tools to facilitate human genome annotation as well as pattern recognition/comparison searches of next-generation sequencing data. Together, these unbiased genomics approaches will be invaluable for identifying new features of developmental and age-related of epigenome remodeling.
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