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Dawid Lab: Section on Developmental Biology

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Igor Dawid, who heads the Section for Developmental Biology, and colleagues study early development in the frog and zebrafish. Recent efforts focused on the regulation of the formation of the caudal region and the neural crest in the zebrafish embryo. The Wnt target gene cdx4 controls development of caudal tissues and is essential for hematopoiesis. Regulation of cdx4 by Wnt signaling was shown to be modulated by E4f1 through dissociation of the Tcf3 repressor complex. This mechanism assures robustness of the graded expression of cdx4 in the caudal body region. In a second project, the group studied the regulation of neural crest specification by the BTB domain protein Kctd15. Kctd15 inhibits neural crest formation and is believed to act to assure separation of the neural crest and pre-placodal domains in the zebrafish embryo.

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Last Reviewed: 11/30/2012

Contact Information

Name: Dr Igor B Dawid
Senior Investigator
Section for Developmental Biology

Staff Directory
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology