Skip Navigation
Print Page

Clark Lab: Section on Chromatin and Gene Expression

Skip sharing on social media links
Share this:
Skip Internal Navigation ​​​​


David Clark and his colleagues in the Section on Chromatin and Gene Expression study the role of chromatin structure in gene activation. Gene activation must occur in the presence of nucleosomes, which are compact structures capable of blocking transcription at every step. To circumvent this chromatin block, eukaryotic cells possess chromatin-remodeling and histone-modifying complexes. The laboratory uses Next-Generation paired-end sequencing to determine nucleosome positions genome-wide in the yeast Saccharomyces cerevisiae and finds that canonical nucleosomes are not uniquely positioned with respect to the DNA. In contrast, the specialized centromeric nucleosomes are perfectly positioned. Gene activation correlates with large-scale loss of nucleosomes and re-positioning of the remaining nucleosomes over entire genes

Last Reviewed: 11/30/2012

Contact Information

Name: Dr David Clark
Senior Investigator
Unit on Chromatin and Gene Expression
Phone: 301-496-6966
Fax: 301-480-1907

Staff Directory
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology