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Stratakis Lab: Section on Endocrinology and Genetics

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Clinical Research

For more information on ongoing laboratory research at SEGEN, go to the Stratakis Lab site.

Pituitary Tumors


Protocol 97CH0076: For consent and assent forms, please go the Stratakis Lab site.


Studies on multiple adrenal tumors, Allgrove syndrome, Carney triad, familial hyperaldosteronism and other genetic endocrine conditions



Clinical Research Studies

Adrenal Tumors
What are the adrenal glands?

These are the sole source in the body responsible for secreting three different classes of hormones: glucocorticoids, mineraolocorticoids, and catecholamines. They also are an important source of sex steroids, especially before puberty. Glucocorticoids (in humans cortisol, although different hormones in rodents) are necessary for maintenance of a variety of metabolic processes, including maintenance of blood sugar as well as regulating inflammatory states. Mineralocorticoids (aldosterone) are needed for the body to properly regulate salt and water balance. These hormones, as well as the sex steroids produced by the adrenals, are all manufactured in the outer portion of the adrenal gland, known as the adrenal cortex. Tumors of the adrenal gland that secrete these substances are therefore known as "adrenocortical tumors".

The remaining hormones secreted by the adrenal gland are the catecholamines, comprised mainly of epinephrine and norepinephrine (also known as adrenaline and noradrenaline). These hormones give rise to the "fight or flight" response, and are secreted by the inner portion of the adrenal gland, known as the adrenal medulla. Tumors of this portion of the gland are most commonly known as pheochromocytomas.

Types of adrenal tumors
  • Cortisol producing adenomas (account for about 60% of hormone-secreting adrenocortical tumors)
  • Aldosteronomas (account for about another 30% of tumors)

Please call Dr. Pacak:

Other hormone secreting tumors
  • Benign vs. Malignant Adrenal Tumors
  • Adrenal incidentalomas

Due to the increasing frequency of the use of advanced body imaging techniques (for example, CT, MRI), nodules on the adrenal glands are being detected with ever increasing frequency. Recent retrospective studies estimate that between 1-5% of all adults have a lesion on the adrenal gland that can be detected by imaging (REF). The frequency of these lesions appears to increase roughly parallel with age, such that the older a person is, the more likely he is to have a nodule on the adrenal gland. Because the large majority of these are detected incidentally (that is, during a scan done for other reasons--such as abdominal pain), these lesions have been termed "incidentalomas".

Important!! The information on these pages is provided out of interest and to try to disseminate information about our work amd the particular rare diseases in which we are interested. It is not meant to be encyclopedic or authoritative. Any serious medical concerns should be discussed with appropriate physicans in a timely manner.

Work of Segen on Phosphodieserases

For more information on Segen’s work on Phosphodieserases, see the Stratakis Lab site.


Clinical and Molecular Analysis of ACTH-Independent Steroid Hormone Production in Adrenocortical Tissue

For documents on clinical and molecular analysis of ACTH-Independent steroid hormone production in adrenocortical tissues, please go to the Stratakis Lab site.

Other genetic syndromes: Brancio-otic dysplasia, collagen defects, skeletal dysplasias, growth abnormalities, acromegaloidism



How to Refer a Patient or Send a Sample for Genetic Studies

To refer a patient to one of our studies:
  • For pediatric endocrine patients with doagnosis other than Cushing syndrome or a pitutary tumor: Call Meg Keil at 301-4353391 Or e-mail at:
  • For patients with Cushing syndrome or with any pituitary tumor: call Eileen Lang at 301-496-0862 or email at: or Meg Keil at the numbers above.
  • For patients with any genetic condition use the contact people above or Dr. Margarita Raygada at 301-451-8822 or by email at
To Send a Blood Sample for Genetic Testing:

For instructions for sending a blood sample for genetic testing, please go to the Stratakis Lab site.

Alternatively Dr. Stratakis can be reached at:

Address for the laboratory (Rm 1-3216, CRC, tel 301-4021998):

Building 10, CRC, Rm 1-3330 (East Laboratories), MSC 1103
Bethesda, MD 20892, Tel. 301-496-6683, Fax 301-402-0574

Address for the office and Training Program:

Building 10, Room 9D42, MSC 1830,
Bethesda , MD 20892 , tel. 301-496-6683, fax. 301-480-0378


Last Reviewed: 11/30/2012

Contact Information

Name: Dr Constantine A Stratakis
Senior Investigator
Section on Endocrinology and Genetics
Phone: 301-594-5984
Fax: 301-480-6480

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