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Dasso Lab: Section on Cell Cycle Regulation

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Overview

The Section on Cell Cycle Regulation, headed by Mary Dasso, studies mechanisms that assure accurate chromosome segregation in metazoan cells. The group recently showed that the SUMO pathway for covalent protein modification plays an essential role in the assembly of kinetochores, the proteinaceous structures that attach sister chromatids to mitotic spindles. Members of the group demonstrated that proteins of the nuclear pore complex and Ran GTPase pathway are essential for the robust formation of the microtubule fibers that link kinetochores to mitotic spindles and mediate the segregation of chromosomes into daughter cells at anaphase.

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Last Updated Date: 04/22/2014
Last Reviewed Date: 04/22/2014

Contact Information

Name: Ms Mary Dasso
Senior Investigator
Section on Cell Cycle Regulation
Phone: 301-402-1555
Fax: 301-402-1323
Email: mdasso@helix.nih.gov

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