Publications

  1. Seah MKY, Wang Y, Goy PA, Loh HM, Peh WJ, Low DHP, Han BY, Wong E, Leong EL, Wolf G, Mzoughi S, Wollmann H, Macfarlan TS, Guccione E, Messerschmidt DM. The KRAB-zinc finger protein ZFP708 mediates epigenetic repression at RMER19B retrotransp0sons. Development2019 Apr 1. pii: dev.170266. doi: 10.1242/dev.170266. PMID:30846446
  2. Dunn-Fletcher CE, Muglia LM, Pavlicev M, Wolf G, Sun MA, Hu YC, Huffman E, Tumukuntala S, Thiele K, Mukherjee A, Zoubovsky S, Zhang X, Swaggart KA, Lamm KYB, Jones H, Macfarlan TS, Muglia LJ.  Anthropoid primate-specific retroviral element THE1B controls expression of CRH in placenta and alters gestation length. PLoS Biol. 2018 Sep 19;16(9):e2006337. doi: 10.1371/journal.pbio.2006337. PMID:30231016
  3. Honson DD, Macfarlan TS. A lncRNA-like Role for LINEs in Develoment. Dev Cell. 2018 Jul 16;46(2):132-134. doi: 10.1016/j.devcel.2018.06.022. PMID: 30016617
  4. Patel A*, Yang P*, Tinkham M, Pradham M, Sun MA, Wang Y, Hoang D, Wolf G, Horton JR, Zhang X, Macfarlan TS**, Cheng X**. DNA conformation induces adaptable binding by tandem zinc finger proteins. Cell 2018. Mar 22;173(1):221-233.e12  doi.org/10.1016/j.cell.2018.02.058  1. PMID:29551271   * Indicates co-first authors  **  co-corresponding authors
  5. Yang P, Wang Y, Macfarlan TS.  The Role of KRAB-ZFPs in Transposable Element Repression and Mammalian Evolution. Trends Genet. 2017 Sep 18. pii: S0168-9525(17)30144-0. doi: 10.1016/j.tig.2017.08.006. PMID:28935117
  6. Wolf G, Rebollo R, Karimi MM, Ewing AD, Kamada R, Wu W, Wu B, Bachu M, Ozato K, Faulkner GJ, Mager DL, Lorincz MC, Macfarlan TS. On the role of H3.3 in retroviral silencing.  Nature 2017 Aug 3; 548E1-E3. doi:10.1038/nature23277 
  7. Yang P, Wang Y, Hoang D, Tinkham M, Patel A, Sun M-A, Wolf G, Baker M, Chien H-C, Lai N, Cheng X, Shen C-K J, and Macfarlan TS. A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568.  Science. 2017 May 19;356(6339):757-759. doi: 10.1126/science.aah6895.
  8. Choi YJ, Lin CP, Risso D, Chen S, Kim TA, Tan MH, Li JB, Wu Y, Chen C, Xuan Z, Macfarlan T, Peng W, Lloyd K, Kim SY, Speed TP, He L.  Deficiency of microRNA miR-34a expands cell fate potential in pluripotent stem cells.  Science. 2017 Jan 12. pii: aag1927. doi: 10.1126/science.aag1927.
  9. Wang C, Lee J-E, Lai B, Macfarlan TS Xu B, Zhuang L, Liu C, Peng W, Ge K.  MLL4 controls cell fate by orchestrating de novo enhancer activation. Proc Natl Acad Sci U S A. 2016 Oct 3. pii: 201606857.
  10. Thompson PJ, Macfarlan TS, and Lorincz MC.  Long terminal repeats: from parasitic elements to building blocks of the transcriptional regulatory repertoire. Mol Cell. 2016 June 2, 62(5):766-76. Doi: 10.1016/j.molcell.2016.03.029. PMCID: PMC4910160.
  11. Wasson JA, Simon AK, Myrick DA, Wolf G, Driscoll S, Pfaff SL, Macfarlan TS, and Katz DJ.  Maternally provided LSD1/KDM1A enables the maternal-to-zygotic transition and prevents defects that manifest postnatally.  eLife.2016, 10.7554/eLife.08848. 
  12. Wolf G, Greenberg D, Macfarlan TS. Spotting the enemy within: Targeted silencing of foreign DNA in mammalian genomes by the Kruppel-associated box zinc finger protein family. Mobile DNA. 2015, 6:17. Doi:10.1186/s13100-015-0050-8.
  13. Wolf G, Macfarlan TS. Revealing the complexity of retroviral repression. Cell. 2015 Sep 24; 163 (1):30-2. Doi:10.1016/j.cell.2015.09.014.
  14. Wang J, Telese F, Tan Y, Li W, Jin C, He X, Basnet H, Ma Q, Merkurjev D, Zhu X, Liu Z, Zhang J, Ohgi K, Taylor H, White RR, Macfarlan TS, Pfaff SL, Rosenfeld MG. LSD1n is a H4K20 demethylase regulating memory formation via transcriptional elongation control. Nature Neurosci. 2015 Jul 27. doi: 10.1038/nn.4069
  15. Lee H, Kim M, Kim N, Macfarlan T, Pfaff SL, Mastick GS, Song MR. Slit and Semaphorin signaling governed by Islet transcription factors positions motor neuron somata within the neural tube. Exp Neurol. 2015 Apr 3. pii: S0014-4886(15)00100-4. doi: 10.1016/j.expneurol.2015.03.024.
  16. Wolf G, Yang P, Fuchtbauer A, Fuchtbauer EM, Silva AM, Park C, Nielsen AL, Pedersen FS, and Macfarlan TS. The KRAB zinc finger protein ZFP809 is required to initiate epigenetic silencing of endogenous retroviruses. Genes Dev. 2015 Mar1; 29(5):538-54.  doi: 10.1101/gad.252767.114.
  17. Yang P, Wu W, and Macfarlan TS. A combination of maternal histone variants and chaperones promotes paternal genome activation and boosts somatic cell reprogramming. Bioessays. 2014 Oct 18, doi110.1002/bies.201400072.
  18. Gifford WD, Pfaff SL, and Macfarlan TS. Transposable elements as genetic regulatory substrates in early development.  Trends Cell Biol. 2013 May; 23 (5): 218-26. doi 10.1016/j.tcb.2013.01.001.
  19. Rowe HM, Kapopoulou A, Corsinotti A, Fasching L, MacfarlanTS, Tarabay Y, Viville S, Jakobsson J, Pfaff SL, Trono D. TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells. Genome Res. 2013 Mar;23(3):452-61. doi: 10.1101/gr.147678.112.
  20. Macfarlan TS, Gifford WD, Driscoll S, Rowe HM, Bonanomi D, Lettieri K, Firth A, Singer O, Trono D, and Pfaff SL. Embryonic stem cell potency fluctuates with endogenous retrovirus activity. Nature. 2012 Jun 13 doi: 10.1038/nature11244. 
  21. Macfarlan TS, Gifford WD, Agarwal SA, Driscoll S, Lettieri K, Wang J, Andrews SE, Franco L, Rosenfeld MG, Ren B, and Pfaff SL. Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A. Genes Dev. 2011 Mar 15;25(6):594-607.

Link to "Macfarlan TS" Pubmed Author Search

top of pageBACK TO TOP