Air pollution exposure during pregnancy has been associated with increased infant mortality, preterm delivery, and restricted fetal growth. We use the Community-Multiscale Air Quality (CMAQ) Model to determine exposure for criteria air pollutants, including PM2.5 and ozone, as well as over 30 air toxics, temperature, and relative humidity to examine birth outcome risks in the Consortium on Safe Labor. Nearly 230,000 deliveries from 12 clinical centers across the United States have regional air pollution exposure assigned by CMAQ; the study also incorporates other air pollution modeling strategies based on monitor data. Atmospheric data has also been associated with a subset of deliveries in the Consecutive Pregnancy Study. We have reported on blood pressure and cardiovascular events at labor/delivery, stillbirth, premature rupture of membranes, gestational diabetes mellitus, birth defects, preterm birth, and other adverse perinatal outcomes in relation to air quality and temperature.
Ha S, Nguyen K, Liu D, Männistö T, Nobles C, Sherman S, Mendola P. Ambient temperature and risk of cardiovascular events at labor and delivery: a case-crossover study. Environmental Research. 2017; 159:622-628. PMID: 28926807. PMCID: PMC5624535.
Ha S, Liu D, Zhu Y, Soo Kim S, Sherman S, Grantz KL, Mendola P. Ambient temperature and stillbirth: A multi-center retrospective cohort study. Environmental Health Perspectives. 2017; 125(6):067011. PMID: 28650842. PMCID: PMC5743476.
Ha S, Liu D, Zhu Y, Kim SS, Sherman S, Mendola P. Ambient temperature and early delivery of singleton pregnancies. Environmental Health Perspectives. 2017; 125(3):453-459. PMID: 27580125. PMCID: PMC5332199.
Zhang J, Li J, Wang P, Chen G, Mendola P, Sherman S, Ying Q. Estimating population exposure to ambient polycyclic aromatic hydrocarbon in the United States – Part I: Model development and evaluation. Environment International. 2017; 99:263-274. PMID: 27988136.
Zhu Y, Zhang C, Liu D, Ha S, Kim SS, Pollack A, Mendola P. Ambient air pollution and risk of gestational hypertension. American Journal of Epidemiology. 2017; 186(3):334-343. PMID: 28472208. PMCID: PMC5860464.
Ha S, Zhu Y, Liu D, Sherman S, Mendola P. Ambient temperature and air quality in relation to small for gestational age and term low birth weight. Environmental Research. 2017; 155:394-400. PMID: 28258738. PMCID: PMC5402474.
Ha S, Männistӧ T, Liu D, Sherman S, Ying Q, Mendola P. Air pollution and cardiovascular events at labor and delivery: a case-crossover analysis. Annals of Epidemiology. 2017; 27(6):377-383. PMID: 28552468. PMCID: PMC5533083.
Mendola P, Ha S, Pollack AZ, Zhu Y, Seeni I, Kim SS, Sherman S, Liu D. Chronic and acute ozone exposure in the week prior to delivery is associated with the risk of stillbirth. International Journal of Environmental Research and Public Health. 2017; 14(7). pii: E731. PMID: 28684711. PMCID: PMC5551169.
Mendola P, Wallace M, Hwang BS, Liu D, Robledo C, Männistö T, Sundaram R, Sherman S, Ying Q, Grantz KL. Preterm birth and air pollution: critical windows of exposure for women with asthma. The Journal of Allergy and Clinical Immunology. 2016; 138(2):432-440.e5. PMID: 26944405. PMCID: PMC4975980.
Mendola P, Wallace M, Liu D, Robledo C, Männistö T, Grantz KL. Air pollution exposure and preeclampsia among US women with and without asthma. Environmental Research. 2016; 148:248–255. PMID: 27085496. PMCID: PMC4874861.
Wallace ME, Grantz KL, Liu D, Zhu Y, Kim SS, Mendola P. Exposure to ambient air pollution and premature rupture of membranes. American Journal of Epidemiology. 2016; 183(12):1114-1121. PMID: 27188941. PMCID: PMC4908205.
Zhang J, Wang P, Li J, Mendola P, Sherman S, Ying Q. Estimating population exposure to ambient polycyclic aromatic hydrocarbon in the United States – Part II: Source apportionment and cancer risk assessment. Environment International. 2016; 97:163-170. PMID: 27613001.
Männistö T, Mendola P, Laughon Grantz K, Leishear K, Sundaram R, Sherman S, Ying Q, Liu D. Acute and recent air pollution exposure and cardiovascular events at labor and delivery. Heart. 2015; 101(18):1491-1498. PMID: 26105036. PMCID: PMC5575746.
Zhu Y, Zhang C, Liu D, Grantz KL, Wallace M, Mendola P. Maternal ambient air pollution exposure preconception and during early gestation and offspring congenital orofacial defects. Environmental Research. 2015; 140:714-720. PMID: 26099933. PMCID: PMC4498658.
Männistö T, Mendola P, Liu D, Leishear K, Sherman S, Laughon SK. Acute air pollution exposure and blood pressure at delivery among women with and without hypertension. American Journal of Hypertension. 2015; 28(1):58-72. PMID: 24795401 PMCID: PMC4288121.
Robledo CA, Mendola P, Yeung E, Männistö T, Sundaram R, Liu D, Ying Q, Sherman S, Grantz KL. Preconception and early pregnancy air pollution exposures and risk of gestational diabetes mellitus. Environmental Research. 2015; 137:316-322. PMID: 25601734.
Männistö T, Mendola P, Liu D, Leishear K, Ying Q, Sundaram R. Temporal variation in the acute effects of air pollution on blood pressure measured at admission to labor/delivery. Air Quality, Atmosphere & Health. 2015; 8(1):13-28. DOI: 10.1007/s11869-014-0268-5
Chen G, Li J, Ying Q, Sherman S, Perkins N, Sundaram R, Mendola P. Evaluation of observation-fused regional air quality model results for air pollution exposure estimation. The Science of the Total Environment. 2014; 485-486:563-574. PMID: 24747248 PMCID: PMC4151129.