Gestational diabetes mellitus (GDM), a common pregnancy complication, has been related to short- and long-term adverse health outcomes for both women and their children.
Women who developed GDM had an increased risk of preeclampsia and cesarean delivery during pregnancy, and an increased risk of type 2 diabetes mellitus (T2DM) after pregnancy. Children of women with GDM were more likely to be obese and have impaired glucose tolerance and diabetes in early adulthood.
BBB collaborates with the Epidemiology Branch (EB) on its Diabetes and Women’s Health (DWH) Study, a retrospective cohort study to collect data from approximately 4,000 women from the United States and Denmark who had GDM. The study followed these women initially for 10 years, with an additional 4-year follow-up to collect updated information on major environmental factors and timed biospecimens.
The study focuses on identifying medical, lifestyle, and genetic determinants and their interactions for the progression from GDM to T2DM and its complications. It also investigates biochemical markers that may predict the development of these complications among the pre-diabetic population.
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